TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation.

Autor: Mühlgrabner V; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Peters T; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Velasco Cárdenas RM; Department of Immunology, Faculty of Biology, University of Freiburg, Germany.; Center for Biological Signaling Studies (BIOSS), University of Freiburg, Germany.; Center for Integrative Biological Signaling Studies (CIBSS), University of Freiburg, Germany., Salzer B; St. Anna Children's Cancer Research Institute (CCRI), 1090, Vienna, Austria.; Christian Doppler Laboratory for Next Generation CAR T Cells, 1090, Vienna, Austria., Göhring J; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Plach A; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Höhrhan M; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Perez ID; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Goncalves VDR; Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany., Farfán JS; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK., Lehner M; St. Anna Children's Cancer Research Institute (CCRI), 1090, Vienna, Austria.; Christian Doppler Laboratory for Next Generation CAR T Cells, 1090, Vienna, Austria., Stockinger H; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Schamel WW; Department of Immunology, Faculty of Biology, University of Freiburg, Germany.; Center for Biological Signaling Studies (BIOSS), University of Freiburg, Germany.; Center for Integrative Biological Signaling Studies (CIBSS), University of Freiburg, Germany., Schober K; Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Busch DH; Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany., Hudecek M; Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany., Dushek O; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK., Minguet S; Department of Immunology, Faculty of Biology, University of Freiburg, Germany.; Center for Biological Signaling Studies (BIOSS), University of Freiburg, Germany.; Center for Integrative Biological Signaling Studies (CIBSS), University of Freiburg, Germany., Platzer R; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Huppa JB; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria.

Publikováno v: Science advances [Sci Adv] 2024 Sep 06; Vol. 10 (36), pp. eadj4632. Date of Electronic Publication: 2024 Sep 04.