Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A beta, tau, immunity and lipid processing (vol 51, pg 414, 2019)

Autor: Kunkle, BW, Grenier-Boley, B, Sims, R, Bis, JC, Damotte, V, Naj, AC, Boland, A, Vronskaya, M, van der Lee, SJ, Amlie-Wolf, A, Bellenguez, C, Frizatti, A, Chouraki, V, Martin, ER, Sleegers, K, Badarinarayan, N, Jakobsdottir, J, Hamilton-Nelson, KL, Moreno-Grau, S, Olaso, R, Raybould, R, Chen, YN, Kuzma, AB, Hiltunen, M, Morgan, T, Ahmad, S, Vardarajan, BN, Epelbaum, J, Hoffmann, P, Boada, M, Beecham, GW, Garnier, JG, Harold, D, Fitzpatrick, AL, Valladares, O, Moutet, ML, Gerrish, A, Smith, AV, Qu, LM, Bacq, D, Denning, N, Jian, XQ, Zhao, Y, Del Zompo, M, Fox, NC, Choi, SH, Mateo, I, Hughes, JT, Adams, HH, Malamon, J, Sanchez-Garcia, F, Patel, Y, Brody, JA, Dombroski, BA, Naranjo, MCD, Daniilidou, M, Eiriksdottir, G, Mukherjee, S, Wallon, D, Uphill, J, Aspelund, T, Cantwell, LB, Garzia, F, Galimberti, D, Hofer, E, Butkiewicz, M, Fin, B, Scarpini, E, Sarnowski, C, Bush, WS, Meslage, S, Kornhuber, J, White, CC, Song, Y, Barber, RC, Engelborghs, S, Sordon, S, Voijnovic, D, Adams, PM, Vandenberghe, R, Mayhaus, M, Cupples, LA, Albert, MS, De Deyn, PP, Gu, W, Himali, JJ, Beekly, D, Squassina, A, Hartmann, AM, Orellana, A, Blacker, D, Rodriguez-Rodriguez, E, Lovestone, S, Garcia, ME, Doody, RS, Munoz-Fernadez, C, Sussams, R, Lin, HH, Fairchild, TJ, Benito, YA, Holmes, C, Karamujic-Comic, H, Frosch, MP, Thonberg, H, Maier, W, Roshchupkin, G, Ghetti, B, Giedraitis, V, Kawalia, A, Li, S, Huebinger, RM, Kilander, L, Moebus, S, Hernandez, I, Kamboh, MI, Brundin, R, Turton, J, Yang, Q, Katz, MJ, Concari, L, Lord, J, Beiser, AS, Keene, CD, Helisalmi, S, Kloszewska, I, Kukull, WA, Koivisto, AM, Lynch, A, Tarraga, L, Larson, EB, Haapasalo, A, Lawlor, B, Mosley, TH, Lipton, RB, Solfrizzi, V, Gill, M, Longstreth, WT, Montine, TJ, Frisardi, V, Diez-Fairen, M, Rivadeneira, F, Petersen, RC, Deramecourt, V, Alvarez, I, Salani, F, Ciaramella, A, Boerwinkle, E, Reiman, EM, Fievet, N, Rotter, JI, Reisch, JS, Hanon, O, Cupidi, C, Uitterlinden, AGA, Royall, DR, Dufouil, C, Maletta, RG, de 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Publikováno v: NATURE GENETICS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::1b100d09c77883b93a5fefb9607ead16
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2484

Gene-environment interaction testing in family-based association studies with phenotypically ascertained samples: a causal inference approach.

Autor: Fardo DW, Liu J, Demeo DL, Silverman EK, Vansteelandt S, Fardo, David W, Liu, Jinze, Demeo, Dawn L, Silverman, Edwin K, Vansteelandt, Stijn

Publikováno v: Biostatistics; Jul2012, Vol. 13 Issue 3, p468-481, 14p

Measurement Error and Methodologic Issues in Analyses of the Proportion of Variance Explained in Cognition.

Autor: Nichols E; Center for Economic and Social Research, University of Southern California, VPD, 635 Downey Way, Los Angeles, CA, 90089, USA. emmanich@usc.edu.; Lenoard Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA, 90089, USA. emmanich@usc.edu., Aslanyan V; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, 1845 N. Soto St, Los Angeles, CA, 90032, USA., Adrien TV; Department of Clinical and Health Psychology, University of Florida, 1225 Center Dr, Gainesville, FL, 32603, USA., Andrews RM; Department of Epidemiology, School of Public Health, Boston University, 715 Albany St, Boston, MA, 02118, USA., Fardo DW; Department of Biostatistics, Sanders-Brown Center On Aging, Lexington, KY, 40536, USA., Gavett BE; Department of Neurology, University of California Davis School of Medicine, Sacramento, CA, 95816, USA., Paterson TSE; Department of Psychology, University of Victoria, Victoria, BC, V8W 2Y2, Canada., Turney IC; Taub Institute for Research On Alzheimers Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA., Young CB; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 213 Quarry Road, Palo Alto, CA, 94304, USA., Uanhoro JO; Department of Educational Psychology, University of North Texas, 1300 W. Highland Street Denton, Denton, TX, 76203, USA., Gross AL; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21231, USA., Initiative FTADN

Publikováno v: Neuropsychology review [Neuropsychol Rev] 2024 Nov 20. Date of Electronic Publication: 2024 Nov 20.

GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia.

Autor: Shade LMP; Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY, USA., Katsumata Y; Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY, USA.; Sanders-Brown Center on Aging and Alzheimer's Disease Research Center, University of Kentucky, Lexington, KY, USA., Abner EL; Sanders-Brown Center on Aging and Alzheimer's Disease Research Center, University of Kentucky, Lexington, KY, USA.; Department of Epidemiology and Environmental Health, College of Public Health, University of Kentucky, Lexington, KY, USA., Aung KZ; Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY, USA.; Sanders-Brown Center on Aging and Alzheimer's Disease Research Center, University of Kentucky, Lexington, KY, USA., Claas SA; Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY, USA., Qiao Q; Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY, USA.; Sanders-Brown Center on Aging and Alzheimer's Disease Research Center, University of Kentucky, Lexington, KY, USA., Heberle BA; Sanders-Brown Center on Aging and Alzheimer's Disease Research Center, University of Kentucky, Lexington, KY, USA.; Department of Neuroscience, University of Kentucky College of Medicine, Lexington, KY, USA., Brandon JA; Sanders-Brown Center on Aging and Alzheimer's Disease Research Center, University of Kentucky, Lexington, KY, USA.; Department of Neuroscience, University of Kentucky College of Medicine, Lexington, KY, USA., Page ML; Sanders-Brown Center on Aging and Alzheimer's Disease Research Center, University of Kentucky, Lexington, KY, USA.; Department of Neuroscience, University of Kentucky College of Medicine, Lexington, KY, USA., Hohman TJ; Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Mukherjee S; Department of Medicine, University of Washington, Seattle, WA, USA., Mayeux RP; Department of Neurology, Columbia University, New York City, NY, USA., Farrer LA; Department of Medicine (Biomedical Genetics), Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; Department of Ophthalmology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.; Department of Epidemiology, School of Public Health, Boston University, Boston, MA, USA., Schellenberg GD; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Haines JL; Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Kukull WA; National Alzheimer's Coordinating Center, Department of Epidemiology, University of Washington, Seattle, WA, USA., Nho K; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA., Saykin AJ; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA., Bennett DA; Department of Neurological Sciences, Rush Medical College, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush Medical College, Chicago, IL, USA., Schneider JA; Department of Neurological Sciences, Rush Medical College, Chicago, IL, USA.; Rush Alzheimer's Disease Center, Rush Medical College, Chicago, IL, USA.; Department of Pathology, Rush Medical College, Chicago, IL, USA., Ebbert MTW; Sanders-Brown Center on Aging and Alzheimer's Disease Research Center, University of Kentucky, Lexington, KY, USA.; Department of Neuroscience, University of Kentucky College of Medicine, Lexington, KY, USA.; Division of Biomedical Informatics, Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY, USA., Nelson PT; Sanders-Brown Center on Aging and Alzheimer's Disease Research Center, University of Kentucky, Lexington, KY, USA.; Department of Pathology and Laboratory Medicine, University of Kentucky College of Medicine, Lexington, KY, USA., Fardo DW; Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY, USA. david.fardo@uky.edu.; Sanders-Brown Center on Aging and Alzheimer's Disease Research Center, University of Kentucky, Lexington, KY, USA. david.fardo@uky.edu.

Publikováno v: Nature genetics [Nat Genet] 2024 Nov; Vol. 56 (11), pp. 2407-2421. Date of Electronic Publication: 2024 Oct 08.

Novel multi-omics deconfounding variational autoencoders can obtain meaningful disease subtyping.

Autor: Li Z; BIO3 - Laboratory for Systems Medicine, Department of Human Genetics, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.; Medical Imaging Research Center, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.; BIO3 - Laboratory for Systems Genetics, GIGA Molecular & Computational Biology, University of Liège, Avenue de l'Hôpital 11, 4000 Liège, Belgium., Katz S; Department of Radiology and Nuclear Medicine, Erasmus MC, Dr. Molewaterplein 40, 3015 GD Rotterdam, Netherlands.; Laboratory of Systems and Synthetic Biology, Wageningen University & Research, PO Box 8033, 6700 EJ Wageningen, Netherlands.; LifeGlimmer GmbH, Markelstraße 38, 12163 Berlin, Germany., Saccenti E; Laboratory of Systems and Synthetic Biology, Wageningen University & Research, PO Box 8033, 6700 EJ Wageningen, Netherlands., Fardo DW; Department of Biostatistics, University of Kentucky, 111 Washington Avenue, Lexington, KY 40536, United States.; Sanders-Brown Center on Aging, University of Kentucky, 789 S Limestone, Lexington, KY 40536, United States., Claes P; Medical Imaging Research Center, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.; Department of Human Genetics, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.; Department of Electrical Engineering, ESAT-PSI, KU Leuven, Kasteelpark Arenberg 10, 3001 Leuven, Belgium., Martins Dos Santos VAP; LifeGlimmer GmbH, Markelstraße 38, 12163 Berlin, Germany.; Laboratory of Bioprocess Engineering, WageningenUniversity & Research, PO Box 16, 6700 AA Wageningen, the Netherlands., Van Steen K; BIO3 - Laboratory for Systems Medicine, Department of Human Genetics, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.; BIO3 - Laboratory for Systems Genetics, GIGA Molecular & Computational Biology, University of Liège, Avenue de l'Hôpital 11, 4000 Liège, Belgium., Roshchupkin GV; Medical Imaging Research Center, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.; Department of Epidemiology, Erasmus MC, Dr. Molewaterplein 40, 3015 GD Rotterdam, Netherlands.

Publikováno v: Briefings in bioinformatics [Brief Bioinform] 2024 Sep 23; Vol. 25 (6).