Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Fardin Hosseinpour"'
Publikováno v:
Nucleic Acids Research
Pregnane X receptor (PXR), acting as a xenobiotic-activated transcription factor, regulates the hepatic metabolism of therapeutics as well as endobiotics such as steroid hormones. Given our finding that PXR activation by rifampicin (RIF) represses th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb471a41fa11435dabaf4102cf3b8984
https://doi.org/10.1093/nar/gkr458
https://doi.org/10.1093/nar/gkr458
Publikováno v:
Biochemical and Biophysical Research Communications. 357:603-607
Prolonged therapy with phenobarbital may cause vitamin D deficiency or osteomalacia. In the current study, we propose a novel mechanism for drug-induced osteomalacia involving impaired bioactivation of vitamin D(3) due to decreased 25-hydroxylation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a730c5381e382fe80dbb27800580b187
https://doi.org/10.1016/j.bbrc.2007.03.177
https://doi.org/10.1016/j.bbrc.2007.03.177
Publikováno v:
Molecular Pharmacology. 69:1095-1102
The constitutive active receptor (CAR) in mouse primary hepatocytes undergoes okadaic acid (OA)-sensitive nuclear translocation after activation by xenobiotics such as phenobarbital (PB) and 1,4 bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP). We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96b280aba454c6db7a6e250af512f92
https://doi.org/10.1124/mol.105.019505
https://doi.org/10.1124/mol.105.019505
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1580:133-144
Both a 25-hydroxylation and a 1alpha-hydroxylation are necessary for the conversion of vitamin D(3) into the calcium-regulating hormone 1alpha,25-dihydroxyvitamin D(3). According to current knowledge, the hepatic mitochondrial cytochrome P450 (CYP) 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27511e800db51eb487a7a97972e66f3e
https://doi.org/10.1016/s1388-1981(01)00192-5
https://doi.org/10.1016/s1388-1981(01)00192-5
Publikováno v:
Biochemical Journal. 347:349-356
This paper describes the molecular cloning of a cytochrome P450 enzyme in pig kidney that catalyses the hydroxylations of vitamin D(3) (cholecalciferol) and C(27)-sterols. DNA sequence analysis of the cDNA revealed that the enzyme belongs to the CYP2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a955c0ec830e713e341a4f3401d22a88
https://doi.org/10.1042/bj3470349
https://doi.org/10.1042/bj3470349
Publikováno v:
Biochimica et biophysica acta. 1632(1-3)
The metabolism of 25-hydroxyvitamin D(3) was studied with a crude mitochondrial cytochrome P450 extract from pig kidney and with recombinant human CYP27A1 (mitochondrial vitamin D(3) 25-hydroxylase) and porcine CYP2D25 (microsomal vitamin D(3) 25-hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09988d77722eb196a4b007f4bbe9075f
https://pubmed.ncbi.nlm.nih.gov/12782149
https://pubmed.ncbi.nlm.nih.gov/12782149
Publikováno v:
Biochemical and biophysical research communications. 303(3)
There has been some controversy over whether the 25-hydroxylation of vitamin D(3) is carried out by one enzyme or two and whether this cytochrome P450 enzyme is found in the mitochondrial or microsomal fractions of liver. The pig is currently the onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d869e45dee8626431121f3d7fe7fb6
https://pubmed.ncbi.nlm.nih.gov/12670492
https://pubmed.ncbi.nlm.nih.gov/12670492
Publikováno v:
Biochemical and biophysical research communications. 288(4)
Porcine CYP2D25, microsomal vitamin D(3) 25-hydroxylase, catalyzes the essential first step in the bioactivation of the prohormone vitamin D(3). Although CYP2D25 shows a high degree of sequence identity with other members of the CYP2D subfamily, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81d7b4ce5c17900b893e92e66f0c681
https://pubmed.ncbi.nlm.nih.gov/11689019
https://pubmed.ncbi.nlm.nih.gov/11689019
Autor:
Masahiko Negishi, Rick Moore, Fardin Hosseinpour, Kenji Matsui, Chika Koike, Yoav E. Timsit, Yukio Yamamoto
Publikováno v:
FEBS Letters. (25):4937-4942
Various drugs such as phenobarbital (PB) trigger translocation of constitutive active/adrostane receptor (CAR) from the cytoplasm into the nucleus of mouse liver cells without directly binding to the receptor. We have now characterized the guanine nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7c5ac6dc3f3d7d4c033aca7498c6b1
Publikováno v:
ResearcherID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3613cd2658acdc59659317f6303aef3
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000236206502152&KeyUID=WOS:000236206502152
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000236206502152&KeyUID=WOS:000236206502152
