Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Faramarz Valafar"'
Autor:
Derek Conkle-Gutierrez, Sarah M. Ramirez-Busby, Bria M. Gorman, Afif Elghraoui, Sven Hoffner, Wael Elmaraachli, Faramarz Valafar
Publikováno v:
Frontiers in Microbiology, Vol 14 (2024)
BackgroundRifampicin (RIF) is a key first-line drug used to treat tuberculosis, a primarily pulmonary disease caused by Mycobacterium tuberculosis. RIF resistance is caused by mutations in rpoB, at the cost of slower growth and reduced transcription
Externí odkaz:
https://doaj.org/article/b76eb18710f04ef39fa75e8b8a62b606
Autor:
Joshua M. Thiede, Nicholas A. Dillon, Michael D. Howe, Ranee Aflakpui, Samuel J. Modlin, Sven E. Hoffner, Faramarz Valafar, Yusuke Minato, Anthony D. Baughn
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other antimicrobial agents, PZA is active against Mycobacterium tuberculosis only at low pH. The basis for this conditional drug susceptibility remains u
Externí odkaz:
https://doaj.org/article/8ee355f2a62d421f881cdc358d63bc6d
Autor:
Samuel J. Modlin, Afif Elghraoui, Deepika Gunasekaran, Alyssa M. Zlotnicki, Nicholas A. Dillon, Nermeeta Dhillon, Norman Kuo, Cassidy Robinhold, Carmela K. Chan, Anthony D. Baughn, Faramarz Valafar
Publikováno v:
mSystems, Vol 6, Iss 6 (2021)
ABSTRACT Accurate and timely functional genome annotation is essential for translating basic pathogen research into clinically impactful advances. Here, through literature curation and structure-function inference, we systematically update the functi
Externí odkaz:
https://doaj.org/article/d38fb0ef6dbc4db38915e5bc82ff5dd4
Autor:
Samuel J Modlin, Derek Conkle-Gutierrez, Calvin Kim, Scott N Mitchell, Christopher Morrissey, Brian C Weinrick, William R Jacobs, Sarah M Ramirez-Busby, Sven E Hoffner, Faramarz Valafar
Publikováno v:
eLife, Vol 9 (2020)
This study assembles DNA adenine methylomes for 93 Mycobacterium tuberculosis complex (MTBC) isolates from seven lineages paired with fully-annotated, finished, de novo assembled genomes. Integrative analysis yielded four key results. First, methyltr
Externí odkaz:
https://doaj.org/article/37d5410627424a428faabb57a88c4d9b
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background The genetic basis of virulence in Mycobacterium tuberculosis has been investigated through genome comparisons of virulent (H37Rv) and attenuated (H37Ra) sister strains. Such analysis, however, relies heavily on the accuracy of the
Externí odkaz:
https://doaj.org/article/dd3d627a5be441a0a99533e49029ac73
Autor:
Essam J. Alyamani, Sarah A. Marcus, Sarah M. Ramirez-Busby, Chungyi Hansen, Julien Rashid, Amani El-kholy, Daniel Spalink, Faramarz Valafar, Hussein A. Almehdar, Asif A. Jiman-Fatani, Mohamed A. Khiyami, Adel M. Talaat
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/191d586277b540f3aaebcd27b996f7f8
Autor:
Rebecca E Colman, James M Schupp, Nathan D Hicks, David E Smith, Jordan L Buchhagen, Faramarz Valafar, Valeriu Crudu, Elena Romancenco, Ecaterina Noroc, Lynn Jackson, Donald G Catanzaro, Timothy C Rodwell, Antonino Catanzaro, Paul Keim, David M Engelthaler
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126626 (2015)
Undetected and untreated, low-levels of drug resistant (DR) subpopulations in clinical Mycobacterium tuberculosis (Mtb) infections may lead to development of DR-tuberculosis, potentially resulting in treatment failure. Current phenotypic DR susceptib
Externí odkaz:
https://doaj.org/article/3e2d6ac75d004780beee61353b16a846
Autor:
Antonino Catanzaro, Timothy C Rodwell, Donald G Catanzaro, Richard S Garfein, Roberta L Jackson, Marva Seifert, Sophia B Georghiou, Andre Trollip, Erik Groessl, Naomi Hillery, Valeriu Crudu, Thomas C Victor, Camilla Rodrigues, Grace Shou-Yean Lin, Faramarz Valafar, Edward Desmond, Kathleen Eisenach
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136861 (2015)
The aim of this study was to compare the performance of several recently developed assays for the detection of multi- and extensively drug-resistant tuberculosis (M/XDR-TB) in a large, multinational field trial.Samples from 1,128 M/XDR-TB suspects we
Externí odkaz:
https://doaj.org/article/df2d5307077e439796b84e5699c652b5
Autor:
Faramarz Valafar
Publikováno v:
International Journal of Mycobacteriology, Vol 5, Iss 5, Pp 64-65 (2016)
Externí odkaz:
https://doaj.org/article/fa55dffe592246a7a0aab55318156fc1
Autor:
Jon W Huss, Camilo Orozco, James Goodale, Chunlei Wu, Serge Batalov, Tim J Vickers, Faramarz Valafar, Andrew I Su
Publikováno v:
PLoS Biology, Vol 6, Iss 7, p e175 (2008)
Externí odkaz:
https://doaj.org/article/6598c79cd94f4f018c2f99b028cf1c15