Výsledky vyhledávání - "Farahnaz Mavandadi"

Synthesis and Biochemical Evaluation of Bis(6,7-dimethyl-8-d-ribityllumazines) as Potential Bisubstrate Analogue Inhibitors of Riboflavin Synthase

Autor: Farahnaz Mavandadi, Adelbert Bacher, Mark Cushman, Karl Kugelbrey, Klaus Kis, Donglai Yang

Publikováno v: The Journal of Organic Chemistry. 64:4635-4642

The reaction catalyzed by riboflavin synthase utilizes two identical 6,7-dimethyl-8-D-ribityllumazine substrate molecules. Three bis(6,7-dimethyl-8-D-ribityllumazines) were, therefore, synthesized in which the two lumazine moieties were connected thr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb802aa1e278ac38ddebbe23bf931fb7
https://doi.org/10.1021/jo9821731

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Synthesis of 2,6-Dioxo-(1 H ,3 H )-9- N -ribitylpurine and 2,6-Dioxo-(1 H ,3 H )-8-aza-9- N -ribitylpurine as inhibitors of lumazine synthase and riboflavin synthase

Autor: Karl Kugelbrey, Adelbert Bacher, Mark Cushman, Farahnaz Mavandadi

Publikováno v: Bioorganic & Medicinal Chemistry. 6:409-415

2,6-Dioxo-(1H,3H)-9-N-ribitylpurine (6) and 2,6-dioxo-(1H,3H)-8-aza-9-N-ribitylpurine (7) have been synthesized and evaluated as inhibitors of lumazine synthase and riboflavin synthase. Reaction of 5-amino-6-ribitylaminouracil hydrochloride (8) with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc86d6348f2be8f545cbd8c84a4fc827
https://doi.org/10.1016/s0968-0896(98)00013-3

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Effect of N9-Methylation and Bridge Atom Variation on the Activity of 5-Substituted 2,4-Diaminopyrrolo[2,3-d]pyrimidines against Dihydrofolate Reductases from Pneumocystis carinii and Toxoplasma gondii1a,b

Autor: Aleem Gangjee, Sherry F. Queener, Farahnaz Mavandadi

Publikováno v: Journal of Medicinal Chemistry. 40:1173-1177

The effect of N9-methylation and bridge atom variation on inhibitory potency and selectivity of 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases (DHFR) was studied. Specifically three nonclassical 2,4-diamino-5-((N-methylanilino)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bdb5c8c9dcc1459fb8a6b2cf7f0276f
https://doi.org/10.1021/jm960717q

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2-Amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as Nonclassical Antifolate Inhibitors of Thymidylate Synthase1a,b

Autor: Roy L. Kisliuk, Farahnaz Mavandadi, Aleem Gangjee, John J. McGuire, Sherry F. Queener

Publikováno v: Journal of Medicinal Chemistry. 39:4563-4568

Six novel 2-amino-4-oxo-5-[(substituted phenyl)sulfanyl]pyrrolo[2,3-d]pyrimidines 7-12 were synthesized as potential inhibitors of thymidylate synthase (TS) and as antitumor and/or antibacterial agents. The analogues contain a 5-thio substituent with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d71872f87fff822767ee78b5a6d85021
https://doi.org/10.1021/jm960097t

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Novel 2,4-Diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as Classical and Nonclassical Antifolate Inhibitors of Dihydrofolate Reductases

Autor: Farahnaz Mavandadi, John J. McGuire, Aleem Gangjee, Sherry F. Queener

Publikováno v: Journal of Medicinal Chemistry. 38:2158-2165

Eight novel, nonclassical, antifolate 2,4-diamino-5-(anilinomethyl)pyrrolo[2,3-d]pyrimidines, 1-8, with 3',4',5'-trimethoxyphenyl, 3',4'-dimethoxyphenyl, 2',5'-dimethoxyphenyl, 4'-methoxyphenyl, 2',5'-diethoxyphenyl, 3',4'-dichlorophenyl, 1'-naphthyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bdb764be1e74969d93be84b29c2889
https://doi.org/10.1021/jm00012a016

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ChemInform Abstract: 2-Amino-4-oxo-5-substituted-pyrrolo(2,3-d)pyrimidines as Nonclassical Antifolate Inhibitors of Thymidylate Synthase

Autor: Farahnaz Mavandadi, Aleem Gangjee, John J. McGuire, Sherry F. Queener, Roy L. Kisliuk

Publikováno v: ChemInform. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3f0df19af21807a5121ba8aa02ff8fb
https://doi.org/10.1002/chin.199708148

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ChemInform Abstract: Conformationally Restricted Tricyclic Analogues of Lipophilic Pyrido[2,3-d]pyrimidine Antifolates

Autor: Farahnaz Mavandadi, Sherry F. Queener, Aleem Gangjee

Publikováno v: ChemInform. 32

The effect of conformational restriction of the C9-N10 bridge on inhibitory potency and selectivity of trimetrexate against dihydrofolate reductase, was studied. Specifically three nonclassical tricyclic 1,3-diamino-8-(3′,4′,5′-trimethoxybenzyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38880d36607e2cfb2aa8cdb5ab60ce9b
https://doi.org/10.1002/chin.200127153

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