A practical guide to the handling and administration of personalized transcriptionally attenuated oncolytic adenoviruses (PTAVs)

Autor: Christopher Larson, Bryan Oronsky, Gina Varner, Scott Caroen, Erica Burbano, Elisa Insel, Farah Hedjran, Corey A. Carter, Tony R. Reid

Publikováno v: OncoImmunology, Vol 7, Iss 9 (2018)

The aim of this review is to provide practical information on the handling, storage, and administration procedures for personalized oncolytic adenoviruses (PTAVs), which have recently entered clinical trials. As described herein, personalized oncolyt

Externí odkaz: https://doaj.org/article/27b03899dd7a4c1dad0e0ef4f7231dc9

Encapsulation of adenovirus serotype 5 in anionic lecithin liposomes using a bead-based immunoprecipitation technique enhances transfection efficiency

Autor: Lingzhi Zhang, Farah Hedjran, Natalie Mendez, William C. Trogler, Sarah L. Blair, Andrew C. Kummel, Ralph Feuer, Tony R. Reid, Vanessa Herrera

Publikováno v: Biomaterials, vol 35, iss 35
Mendez, N; Herrera, V; Zhang, L; Hedjran, F; Feuer, R; Blair, SL; et al.(2014). Encapsulation of adenovirus serotype 5 in anionic lecithin liposomes using a bead-based immunoprecipitation technique enhances transfection efficiency. Biomaterials. doi: 10.1016/j.biomaterials.2014.08.010. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/5wn3h6pp

Oncolytic viruses (OVs) constitute a promising class of cancer therapeutics which exploit validated genetic pathways known to be deregulated in many cancers. To overcome an immune response and to enhance its potential use to treat primary and metasta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc4be264e4e04af1f96720e43ab26e3
https://doi.org/10.1016/j.biomaterials.2014.08.010

Control of calcitonin/calcitonin gene-related peptide pre-mRNA processing by constitutive intron and exon elements

Autor: Ronald B. Emeson, N Merillat, Joanne M. Yeakley, Farah Hedjran, J P Morfin, Michael G. Rosenfeld

Publikováno v: Molecular and Cellular Biology. 13:5999-6011

The calcitonin/calcitonin gene-related peptide (CGRP) primary transcript is alternatively spliced in thyroid C cells and neurons, resulting in the tissue-specific production of calcitonin and CGRP mRNAs. Analyses of mutated calcitonin/CGRP transcript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b35374f87d219d47c7a2b17ec1f008b
https://doi.org/10.1128/mcb.13.10.5999

Abstract B50: A novel immunocompetent murine model for replicating oncolytic adenoviral therapy

Autor: Lingzhi Zhang, Tony R. Reid, Christopher A. Larson, Farah Hedjran, Min Yan

Publikováno v: Molecular Cancer Research. 12:B50-B50

Oncolytic adenoviruses are able to replicate selectively in cancerous but not normal human cells and are under investigation as potential cancer therapeutics. Unfortunately, mice are poor model systems for therapy with replication competent adenoviru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::627b9c17f8c2b409947cadb1986d8cca
https://doi.org/10.1158/1557-3125.modorg-b50

High efficiency transduction of chronic lymphocytic leukemia with adenovirus type 35

Autor: Farah Hedjran, Thomas J. Kipps, D. Whitacre, Tony R. Reid

Publikováno v: Journal of Clinical Oncology. 24:6612-6612

6612 Background: Adenovirus (Ad) vectors have been used extensively in genetic manipulation of cultured cells and gene therapy, with the group C Ad serotypes 2 and 5 being most widely used. The group C viruses have been shown to infect target cells i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66cfab92cb05f6f7b1f73809e7ebebed
https://doi.org/10.1200/jco.2006.24.18_suppl.6612