A Reactive Oxygen Species-Scavenging ‘Stealth’ Polymer, Poly(thioglycidyl glycerol), Outperforms Poly(ethylene glycol) in Protein Conjugates and Nanocarriers and Enhances Protein Stability to Environmental and Biological Stressors

Autor: Richard d’Arcy, Farah El Mohtadi, Nora Francini, Carlisle R. DeJulius, Hyunmoon Back, Arianna Gennari, Mike Geven, Maria Lopez-Cavestany, Zulfiye Yesim Turhan, Fang Yu, Jong Bong Lee, Michael R. King, Leonid Kagan, Craig L. Duvall, Nicola Tirelli

Publikováno v: D'Arcy, R, El Mohtadi, F, Francini, N, Dejulius, C R, Back, H, Gennari, A, Geven, M, Lopez-Cavestany, M, Turhan, Z Y, Yu, F, Lee, J B, King, M R, Kagan, L, Duvall, C L & Tirelli, N 2022, ' A Reactive Oxygen Species-Scavenging Stealth' Polymer, Poly(thioglycidyl glycerol), Outperforms Poly(ethylene glycol) in Protein Conjugates and Nanocarriers and Enhances Protein Stability to Environmental and Biological Stressors ', Journal of the American Chemical Society, vol. 144, no. 46, pp. 21304-21317 . https://doi.org/10.1021/jacs.2c09232

This study addresses well-known shortcomings of poly(ethylene glycol) (PEG)-based conjugates. PEGylation is by far the most common method employed to overcome immunogenicity and suboptimal pharmacokinetics of, for example, therapeutic proteins but ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d084ca9f80077be1bc82ced68025a47
https://doi.org/10.1021/jacs.2c09232

Main Chain Polysulfoxides as Active 'Stealth' Polymers with Additional Antioxidant and Anti-Inflammatory Behaviour

Autor: Farah El Mohtadi, Zulfiye Yesim Turhan, Nicola Tirelli, Xiaoye Yang, Richard d'Arcy, Aws Alshamsan

Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 18
El Mohtadi, F, D'Arcy, R, Yang, X, Turhan, Z Y, Alshamsan, A & Tirelli, N 2019, ' Main Chain Polysulfoxides as Active ‘Stealth’ Polymers with Additional Antioxidant and Anti-Inflammatory Behaviour ', International Journal of Molecular Sciences, vol. 20, no. 18, pp. 4583 . https://doi.org/10.3390/ijms20184583
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4583 (2019)

We present the evaluation of a sulfoxide-based polymer (poly(propylene sulfoxide), PPSO) as a potential &lsquo
stealth&rsquo
macromolecule, and at the same time as a pharmacologically active (anti-inflammatory/anti-oxidant) material. The co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da31b91330c2105d56937843a878c9b6
https://pubmed.ncbi.nlm.nih.gov/31533205

Oxidation-Responsive Materials: Biological Rationale, State of the Art, Multiple Responsiveness, and Open Issues

Autor: Nicola Tirelli, Farah El-Mohtadi, Richard d'Arcy

Publikováno v: Macromolecular Rapid Communications. 40:1800699

In this review, a general introduction to biological oxidants (focusing on reactive oxygen species, ROS) and the biomedical rationale behind the development of materials capable of responding to ROS is provided. The state of the art for preparative a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6d7824646eb11715f4e97107747df7
https://doi.org/10.1002/marc.201800699