Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Farah D, Lubin"'
Autor:
Rudhab Bahabry, Rebecca M. Hauser, Richard G. Sánchez, Silvienne Sint Jago, Lara Ianov, Remy J. Stuckey, R. Ryley Parrish, Lawrence Ver Hoef, Farah D. Lubin
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106638- (2024)
Temporal lobe epilepsy (TLE) is a type of focal epilepsy characterized by spontaneous recurrent seizures originating from the hippocampus. The epigenetic reprogramming hypothesis of epileptogenesis suggests that the development of TLE is associated w
Externí odkaz:
https://doaj.org/article/38770ea5960840009a2f4a3bb67c2e09
Autor:
Silvienne C. Sint Jago, Rudhab Bahabry, Anna Maria Schreiber, Julia Homola, Tram Ngyuen, Fernando Meijia, Jane B. Allendorfer, Farah D. Lubin
Publikováno v:
Epilepsy & Behavior Reports, Vol 25, Iss , Pp 100642- (2024)
The therapeutic potential of aerobic exercise in mitigating seizures and cognitive issues in temporal lobe epilepsy (TLE) is recognized, yet the underlying mechanisms are not well understood. Using a rodent TLE model induced by Kainic acid (KA), we i
Externí odkaz:
https://doaj.org/article/870e488345bc4496980870f0197d40e4
Autor:
Detlev Boison, Susan A. Masino, Farah D. Lubin, Kai Guo, Theresa Lusardi, Richard Sanchez, David N. Ruskin, Joyce Ohm, Jonathan D. Geiger, Junguk Hur
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Epigenetic modifications are crucial for normal development and implicated in disease pathogenesis. While epigenetics continues to be a burgeoning research area in neuroscience, unaddressed issues related to data reproducibility across labor
Externí odkaz:
https://doaj.org/article/07e8511c0c8240bcb8721f26619b6d55
Autor:
Richard G. Sánchez, R. Ryley Parrish, Megan Rich, William M. Webb, Roxanne M. Lockhart, Kazuhito Nakao, Lara Ianov, Susan C. Buckingham, Devin R. Broadwater, Alistair Jenkins, Nihal C. de Lanerolle, Mark Cunningham, Tore Eid, Kristen Riley, Farah D. Lubin
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 531-543 (2019)
Temporal Lobe Epilepsy (TLE) is frequently associated with changes in protein composition and post-translational modifications (PTM) that exacerbate the disorder. O-linked-β-N-acetyl glucosamine (O-GlcNAc) is a PTM occurring at serine/threonine resi
Externí odkaz:
https://doaj.org/article/e85940fd44384bb39c36e9385352c0cb
Autor:
Katelynn M Corder, Mariana A Cortes, Aundrea F Bartley, Samantha A Lear, Farah D Lubin, Lynn E Dobrunz
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200809 (2018)
GABAergic dysfunction has been implicated in a variety of neurological and psychiatric disorders, including anxiety disorders. Anxiety disorders are the most common type of psychiatric disorder during adolescence. There is a deficiency of GABAergic t
Externí odkaz:
https://doaj.org/article/ddf14bf8d4bb43c8a29f2fdf017255a2
Publikováno v:
Biology, Vol 4, Iss 2, Pp 298-313 (2015)
A decline in long-term memory (LTM) formation is a common feature of the normal aging process, which corresponds with abnormal expression of memory-related genes in the aged hippocampus. Epigenetic modulation of chromatin structure is required for pr
Externí odkaz:
https://doaj.org/article/604cf539119c46bf81269492a13cc83d
Autor:
Farah D. Lubin, Jennifer Sherwood, Megan Rich, W. R. Willoughby, Yuping Bao, Quentin A. Whitsitt, Magdelene Lee, Mark Bolding, Lynn E. Dobrunz, Aundrea F. Bartley
Publikováno v:
J Control Release
There is an ongoing need for noninvasive tools to manipulate brain activity with molecular, spatial and temporal specificity. Here we have investigated the use of MRI-visible, albumin-based nanoclusters for noninvasive, localized and temporally speci
Autor:
Victoria Huang, Benjamin W. Henderson, Farah D. Lubin, Mark E Pepin, William M. Webb, Anderson A. Butler, Jeremy H. Herskowitz, Ashleigh B. Irwin, Adam R. Wende, Andrew E. Cash
Publikováno v:
Biol Psychiatry
Background Epigenetic mechanisms are critical for hippocampus-dependent memory formation. Building on previous studies that implicate the N-lysine methyltransferase SETD6 in the activation of nuclear factor-κB RELA (also known as transcription facto
Autor:
Jennifer Sherwood, Seungjo Park, Yonghyun Kim, Angelo J. Antone, Rebecca M. Hauser, Yuping Bao, Brianna T. Beswick, Farah D. Lubin
Publikováno v:
ACS Applied Nano Materials. 3:1542-1552
Ultrasmall iron oxide nanoparticles (USIONPs) have been recently developed as labeling probes for T2 magnetic resonance imaging contrast agents. However, their use in stem cell tracking has been limited, especially as T1 contrast agents. In this stud
Publikováno v:
Cellscience
Epigenetics has been proposed as a molecular mechanism involved in encoding long-term memories. Specifically DNA methylation, an epigenetic mechanism thought to be static following cell differentiation, has been implicated as a dynamic transcription