Design, synthesis and cytotoxic evaluation of new thieno[2,3-d]pyrimidine analogues as VEGFR-2/AKT dual inhibitors, apoptosis and autophagy inducers.

Autor: Abd El-Mawgoud HK; Chemistry Department, Faculty of Women for Arts, Science and Education, Ain Shams University, Heliopolis, 11767 Cairo, Egypt. Electronic address: Heba.Kamal@women.asu.edu.eg., AboulMagd AM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University (NUB), Beni-Suef, Egypt. Electronic address: asmaa.aboulmaged@nub.edu.eg., Nemr MTM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Eini Street 11562, Cairo, Egypt., Hemdan MM; Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, 11566 Cairo, Egypt., Hassaballah AI; Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, 11566 Cairo, Egypt., Farag PS; Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, 11566 Cairo, Egypt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107622. Date of Electronic Publication: 2024 Jul 09.

New 1,3,4-thiadiazoles as potential anticancer agents: pro-apoptotic, cell cycle arrest, molecular modelling, and ADMET profile.

Autor: Hekal MH; Department of Chemistry, Faculty of Science, Ain Shams University Abbassia 11566 Cairo Egypt., Farag PS; Department of Chemistry, Faculty of Science, Ain Shams University Abbassia 11566 Cairo Egypt., Hemdan MM; Department of Chemistry, Faculty of Science, Ain Shams University Abbassia 11566 Cairo Egypt., El-Sayed AA; Department of Chemistry, Faculty of Science, Ain Shams University Abbassia 11566 Cairo Egypt., Hassaballah AI; Department of Chemistry, Faculty of Science, Ain Shams University Abbassia 11566 Cairo Egypt., El-Sayed WM; Department of Zoology, Faculty of Science, Ain Shams University Abbassia 11566 Cairo Egypt waelelhalawany@hotmail.com wael_farag@sci.asu.edu.eg +202 2684 2123 +202 2482 1633.

Publikováno v: RSC advances [RSC Adv] 2023 May 25; Vol. 13 (23), pp. 15810-15825. Date of Electronic Publication: 2023 May 25 (Print Publication: 2023).

The Reformatsky analogous reaction for the synthesis of novel β-thioxoesters via using aroyl isothiocyanates under solvent-free ball milling and conventional conditions.

Autor: Farag PS; Chemistry Department, Faculty of Science, Ain Shams University Abbassia 11566 Cairo Egypt ayaibrahim@sci.asu.edu.eg., Hemdan MM; Chemistry Department, Faculty of Science, Ain Shams University Abbassia 11566 Cairo Egypt ayaibrahim@sci.asu.edu.eg., Hassaballah AI; Chemistry Department, Faculty of Science, Ain Shams University Abbassia 11566 Cairo Egypt ayaibrahim@sci.asu.edu.eg.

Publikováno v: RSC advances [RSC Adv] 2022 Apr 05; Vol. 12 (17), pp. 10204-10208. Date of Electronic Publication: 2022 Apr 05 (Print Publication: 2022).

Design, microwave assisted synthesis, and molecular modeling study of some new 1,3,4-thiadiazole derivatives as potent anticancer agents and potential VEGFR-2 inhibitors.

Autor: Atta-Allah SR; Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566 Cairo, Egypt. Electronic address: saadrm1964@sci.asu.edu.eg., AboulMagd AM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University (NUB), Beni-Suef, Egypt. Electronic address: asmaa.aboulmaged@nub.edu.eg., Farag PS; Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566 Cairo, Egypt.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2021 Jul; Vol. 112, pp. 104923. Date of Electronic Publication: 2021 Apr 17.