Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Fara Faye Regis"'
Autor:
Catherine J. Wu, Alexander Meissner, Ruben D. Carrasco, Lili Wang, Anthony Letai, Donna S. Neuberg, Andreas Gnirke, John C. Aster, Thomas J. Kipps, Jennifer R. Brown, Stephan Stilgenbauer, Clare Sun, Eugen Tausch, Stacey M. Fernandes, Elizabeth Witten, Mei Zheng, Kristen Stevenson, Gabriela Brunsting Hoffmann, Arman Mohammad, Laura Z. Rassenti, Fara Faye Regis, Leah Billington, Nathan Dangle, Catherine Gutierrez, Mohamed Uduman, Fabienne Lucas, Salma Parvin, Elisa ten Hacken, Helene Kretzmer, Shanye Yin, Anat Biran
Chronic lymphocytic leukemia (CLL) is characterized by disordered DNA methylation, suggesting these epigenetic changes might play a critical role in disease onset and progression. The methyltransferase DNMT3A is a key regulator of DNA methylation. Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f34f1ed232ea25d03164adab3f29d8f8
https://doi.org/10.1158/0008-5472.c.6513540.v1
https://doi.org/10.1158/0008-5472.c.6513540.v1
Autor:
Laura Z. Rassenti, Elisa Ten Hacken, Arman W. Mohammad, Eugen Tausch, Lili Wang, Mohamed Uduman, Jennifer R. Brown, Ruben D. Carrasco, Andreas Gnirke, Stacey M. Fernandes, Shanye Yin, Elizabeth Witten, Clare Sun, Catherine J. Wu, Alexander Meissner, Nathan J Dangle, Catherine Gutierrez, Fara Faye Regis, Gabriela Brunsting Hoffmann, Fabienne Lucas, Thomas J. Kipps, Kristen E. Stevenson, Donna Neuberg, Anthony Letai, Jon C. Aster, Anat Biran, Stephan Stilgenbauer, Salma Parvin, Mei Zheng, Helene Kretzmer, Leah Billington
Publikováno v:
Cancer Res
Cancer research, vol 81, iss 24
Cancer research, vol 81, iss 24
Chronic lymphocytic leukemia (CLL) is characterized by disordered DNA methylation, suggesting these epigenetic changes might play a critical role in disease onset and progression. The methyltransferase DNMT3A is a key regulator of DNA methylation. Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb83f15b36b42704965ca7bce54e9f73
https://europepmc.org/articles/PMC8678341/
https://europepmc.org/articles/PMC8678341/
Autor:
Anat Biran, Blake Tye, Fara Faye Regis, Aviv Liani, Elisa Ten Hacken, Lili Wang, Binyamin A. Knisbacher, Mei Zheng, Leah Billington, Peyton Waddicor, Aviv Regev, Kenneth J. Livak, María Hernández-Sánchez, Shuqiang Li, Catherine Gutierrez, Gad Getz, Heather Joyal, Donna Neuberg, Ruben D. Carrasco, Florence Cymbalista, Ziao Lin, Stirling Churchman, Sichen Shao, Fabienne Lucas, Elizabeth Witten, Miguel Quijada Álamo, Tamara Ouspenskaia, Aziz Al'Khafaji, Catherine J. Wu, Gregory Lazarian, Doris Fu
Publikováno v:
Blood. 136:28-29
Amongst the novel putative drivers identified by large-scale sequencing studies of chronic lymphocytic leukemia (CLL) is the ribosomal protein RPS15. Mutated in 5.3% of CLL, it co-occurs with heterozygous TP53 alterations in 36% of RPS15-mutated samp
Autor:
Adrian Wiestner, Fara Faye Regis, Lili Wang, Jing Sun, Esther A. Obeng, Rutendo Gambe, Jean Fan, Shanye Yin, Angela N. Brooks, Amaro Taylor-Weiner, Emanuela M. Ghia, Carrie Cibulskis, Robin Reed, Thomas J. Kipps, Donna Neuberg, Ignaty Leshchiner, Ruben D. Carrasco, Mark D. Fleming, Zachary J. Cartun, James A. DeCaprio, Benjamin L. Ebert, Youzhong Wan, Elisa Ten Hacken, Sarah E. M. Herman, Catherine J. Wu, Laura Z. Rassenti, Gad Getz, Aina Zurita Martinez, Dean R. Campagna
Publikováno v:
Cancer cell, vol 35, iss 2
SF3B1 is recurrently mutated in chronic lymphocytic leukemia (CLL), but its role in the pathogenesis of CLL remain elusive. Here, we show that conditional expression of Sf3b1-K700E mutation in mouse B cells disrupts pre-mRNA splicing, alters cell dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a552fc6456f9a24e7ec4a5a8d172d93c
https://escholarship.org/uc/item/101965h5
https://escholarship.org/uc/item/101965h5
Autor:
Matthew S. Davids, Fara Faye Regis, Mei Zheng, Michaela Gruber, Jing Sun, Lillian Werner, Laura Z. Rassenti, Jessica Wong, Angela N. Brooks, Anthony Letai, Lili Wang, Catherine J. Wu, Thomas J. Kipps, Michael P. Thomas, Robin Reed, Jing Deng, Matthew Meyerson, Ruben D. Carrasco, Michael Seiler, Ekaterina Kim, Elisa Ten Hacken, Shanye Yin, Jan A. Burger, Amy L. Gill, Pavan Bachireddy, Silvia Buonamici, Rebecca Valentin, Pete Smith, Emanuela M. Ghia, Donna Neuberg
Publikováno v:
JCI insight, vol 3, iss 19
The identification of targetable vulnerabilities in the context of therapeutic resistance is a key challenge in cancer treatment. We detected pervasive aberrant splicing as a characteristic feature of chronic lymphocytic leukemia (CLL), irrespective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1164f1863e109b871fd48181d528273
https://escholarship.org/uc/item/70g3v1fm
https://escholarship.org/uc/item/70g3v1fm
Autor:
Katia Georgopoulos, Catherine J. Wu, Tomasz Sevastianik, Daniel Tom, Gregory Lazarian, Alba Font-Tello, Shanye Yin, Fara Faye Regis, Donna Neuberg, Ruben D. Carrasco, Mei Zheng, Amy L. Gill, Elisa Ten Hacken, Lili Wang
Publikováno v:
Blood. 132:668-668
Large-scale DNA sequencing efforts in chronic lymphocytic leukemia (CLL) have identified a broad array of putative cancer drivers arising from somatic mutations in this disease, but functional understanding of the impact of these genetic events on CL
Autor:
Ruben D. Carrasco, Shanye Yin, Adrian Wiestner, Lili Wang, Mark D. Fleming, Aina Zurita Martinez, Dean R. Campagna, Fara Faye Regis, Ignaty Leshchiner, Gad Getz, Benjamin L. Ebert, Sarah E. M. Herman, Elisa Ten Hacken, Esther A. Obeng, Angela N. Brooks, Catherine J. Wu
Publikováno v:
Blood. 132:947-947
Collective large-scale sequencing efforts have unexpectedly revealed the high frequency of mutations in the splicing factor genes (SF3B1, U2AF1, SRSF2, ZRSR2) in various solid and hematological cancers, suggesting the association of splicing dysregul
Autor:
Zachary J. Cartun, Mike Thomas, Silvia Buonamici, Donna Neuberg, Lili Wang, Jing Deng, Fara Faye Regis, Anthony Letai, Kaitlyn Baranowski, Ruben D. Carrasco, Catherine J. Wu, Elisa Ten Hacken
Publikováno v:
Clinical Cancer Research. 23:29-29
The spliceosome component SF3B1 is among the most frequently mutated genes in CLL (Landau et al. Nature 2015), and its mutations are associated with transcriptomic changes in numerous pathways involved in the regulation of CLL-cell survival (Wang et