Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Fanxiu Zhu"'
Autor:
Tracey N Bell, Aubrey E Kusi-Appiah, Vincent Tocci, Pengfei Lyu, Lei Zhu, Fanxiu Zhu, David Van Winkle, Hongyuan Cao, Mandip S Singh, Steven Lenhert
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0304736 (2024)
High throughput screening of small molecules and natural products is costly, requiring significant amounts of time, reagents, and operating space. Although microarrays have proven effective in the miniaturization of screening for certain biochemical
Externí odkaz:
https://doaj.org/article/9c98753d087a4565a2560f2ed1a343a0
Autor:
Anita Alexa, Péter Sok, Fridolin Gross, Krisztián Albert, Evan Kobori, Ádám L. Póti, Gergő Gógl, Isabel Bento, Ersheng Kuang, Susan S. Taylor, Fanxiu Zhu, Andrea Ciliberto, Attila Reményi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The herpesvirus protein ORF45 can bind the two host kinases ERK and RSK but how this affects cell signalling is unclear. Here, the authors show that ORF45 hijacks the ERK-RSK complex by binding to the two kinases with optimized linear motifs and inte
Externí odkaz:
https://doaj.org/article/b1961af753104939b45873b5e2d5dcfc
Autor:
Zhenshan Liu, Xin Wang, Chengrong Liu, Hongying Deng, Wenshu Li, Xiaoqian Wang, Xue Xu, Maggie Z X Xiao, Chunxia Wang, Yucai Zhang, Joyce Fu, Fanxiu Zhu, Qiming Liang
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1010504 (2022)
RSK1, an essential cellular kinase for Kaposi's sarcoma-associated herpesvirus (KSHV) replication, is highly phosphorylated and SUMOylated during KSHV lytic cycle, which determine the substrate phosphorylation and specificity of RSK1, respectively. H
Externí odkaz:
https://doaj.org/article/a812e29767314ff3bc6877ac10cbf4b4
Autor:
Zhenshan Liu, Chengrong Liu, Xin Wang, Wenwei Li, Jingfan Zhou, Peixian Dong, Maggie Z X Xiao, Chunxia Wang, Yucai Zhang, Joyce Fu, Fanxiu Zhu, Qiming Liang
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010123 (2021)
RSK1, a downstream kinase of the MAPK pathway, has been shown to regulate multiple cellular processes and is essential for lytic replication of a variety of viruses, including Kaposi's sarcoma-associated herpesvirus (KSHV). Besides phosphorylation, i
Externí odkaz:
https://doaj.org/article/4cd0fdd075f3470e9f3777ac94cbef42
Autor:
Lielian Zuo, Yan Xie, Jinyong Tang, Shuyu Xin, Lingzhi Liu, Siwei Zhang, Qijia Yan, Fanxiu Zhu, Jianhong Lu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 17, Iss , Pp 175-184 (2019)
Nasopharyngeal carcinoma (NPC) is an invasive head-and-neck tumor with Epstein-Barr virus (EBV) as an important etiological cause. The EBV oncoprotein Latent membrane protein 1 (LMP1) can be trafficked into exosomes with unclear roles, and this traff
Externí odkaz:
https://doaj.org/article/794a7ac026fe4b7e9b89d641f985e450
Autor:
Debipreeta Bhowmik, Fanxiu Zhu
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Sensing of viral constituents is the first and critical step in the host innate immune defense against viruses. In mammalian cells, there are a variety of pathogen recognition receptors (PRRs) that detect diverse pathogen-associated molecular pattern
Externí odkaz:
https://doaj.org/article/62eafa42d9fb4796858b945f5b66d099
Autor:
Shuyu Xin, Shujuan Du, Lingzhi Liu, Yan Xie, Lielian Zuo, Jing Yang, Jingjin Hu, Wenxing Yue, Jing Zhang, Pengfei Cao, Fanxiu Zhu, Jianhong Lu
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1)-mediated DNA episomal genome replication and persistence are essential for the viral pathogenesis. Cyclophilin A (CYPA) is upregulated in EBV-associated nasopharyngeal carcinoma (NPC) with unknown ro
Externí odkaz:
https://doaj.org/article/26ef176c86ec41bd8246bbc446530373
Autor:
Joseph Gillen, Fanxiu Zhu
Publikováno v:
Viruses, Vol 13, Iss 9, p 1828 (2021)
The Open Reading Frame 45 (ORF45) of Kaposi sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific, immediate-early, tegument protein required for efficient viral replication and virion production. We have previously shown that ORF45 in
Externí odkaz:
https://doaj.org/article/fda1cf49bbd24531adddea6f349f6b0c
Publikováno v:
Genomics Data, Vol 2, Iss C, Pp 114-116 (2014)
In the eukaryotic nucleus, DNA is packaged into chromatin. The fundamental subunit of chromatin is the nucleosome, DNA is wrapped 1.6 times around a histone octamer core. Nuclear processes in eukaryotes are impacted by whether regulatory DNA is occup
Externí odkaz:
https://doaj.org/article/a94811f8cf5e4df48acba94ce59e59d6
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005332 (2015)
Herpesviruses acquire their envelope by budding into the lumen of cytoplasmic membrane vesicles. This process is initiated by component(s) on viral particles, which recognize the budding site where the viral glycoproteins are present and recruit cell
Externí odkaz:
https://doaj.org/article/b432be1d7a504430b1f43eb75311ff8c