Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Fanxing Xu"'
Publikováno v:
Journal of Advanced Research, Vol 58, Iss , Pp 105-115 (2024)
Background: Diabetes mellitus (DM) is a long-term metabolic disease accompanied by difficulties in wound healing placing a severe financial and physical burden on patients. As one of the important signal transduction molecules, both endogenous and ex
Externí odkaz:
https://doaj.org/article/1bee5217f09a415f8626952d06b4390a
Autor:
Xinyi Shi, Chun Chu, Xiang Li, Luxin Zhang, Xiaorong Zhang, Na Chen, Weiwei Liu, Zixuan Jiao, Takashi Ikejima, Fanxing Xu
Publikováno v:
CyTA - Journal of Food, Vol 21, Iss 1, Pp 442-450 (2023)
ABSTRACTSilibinin is a natural flavonoid with anti-diabetic activity. Glucagon-like peptide−1 (GLP−1), an intestinal hormone mainly secreted from L cells, which regulates insulin production and sensitivity, appears to be a potential therapeutic s
Externí odkaz:
https://doaj.org/article/930f995cf34546fc8a65b4fd1a490534
Autor:
Xiang Gao, Baojia Sun, Yonglian Hou, Lilin Liu, Jianan Sun, Fanxing Xu, Dahong Li, Huiming Hua
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1870-1883 (2022)
Sinomenine, a morphinane-type isoquinoline-derived alkaloid, was first isolated from stems and roots of Sinomenium diversifolius (Miq.) in 1920. Later discovery by researchers confirmed various essential biological efficacy sinomenine exerted in vitr
Externí odkaz:
https://doaj.org/article/0e6ad54ab75440b89647c55ddddb1f49
Autor:
Xu Hu, Yan Xiao, Jianan Sun, Bao Ji, Shanshan Luo, Bo Wu, Chao Zheng, Peng Wang, Fanxing Xu, Keguang Cheng, Huiming Hua, Dahong Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1148-1157 (2021)
As one of the most lethal diseases, pancreatic cancer shows a dismal overall prognosis and high resistance to most treatment modalities. Furthermore, pancreatic cancer escapes early detection during the curable period because early symptoms rarely em
Externí odkaz:
https://doaj.org/article/cd899665df9a4d9bae27ef15651ca5d8
Autor:
Dongyan Feng, Le Ren, Jiaqi Wu, Lingling Guo, Zhitao Han, Jingjing Yang, Wei Xie, Yanbing Wang, Fanxing Xu, Xin Su, Dahong Li, Hao Cao
Publikováno v:
Molecules, Vol 28, Iss 4, p 1883 (2023)
Furin is a potential target protein associated with numerous diseases; especially closely related to tumors and multiple viral infections including SARS-CoV-2. Most of the existing efficient furin inhibitors adopt a substrate analogous structure, and
Externí odkaz:
https://doaj.org/article/c0fa85bfa4c54b6fbaf93a538eee853c
Autor:
Runwei Jiao, Fanxing Xu, Xiaofang Huang, Haonan Li, Weiwei Liu, Hao Cao, Linghe Zang, Zhanlin Li, Huiming Hua, Dahong Li
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 759-772 (2020)
A series of furoxan derivatives of chromone were prepared. The antiproliferative activities were tested against five cancer cell lines HepG2, MCF-7, HCT-116, B16, and K562, and two normal human cell lines L-02 and PBMCs. Among them, compound 15a exhi
Externí odkaz:
https://doaj.org/article/ba8f641a3ffa42949ea25cd62d3642b0
Autor:
Xu Li, Jingxian Wu, Fanxing Xu, Chun Chu, Xiang Li, Xinyi Shi, Wen Zheng, Zhenzhong Wang, Ying Jia, Wei Xiao
Publikováno v:
Molecules, Vol 27, Iss 18, p 6010 (2022)
Diabetes mellitus, a metabolic disease mainly characterized by hyperglycemia, is becoming a serious social health problem worldwide with growing prevalence. Many natural compounds have been found to be effective in the prevention and treatment of dia
Externí odkaz:
https://doaj.org/article/f726eec888634213a2ecf1366e444f5f
Autor:
Haonan Li, Fanxing Xu, Gang Gao, Xiang Gao, Bo Wu, Chao Zheng, Peng Wang, Zhanlin Li, Huiming Hua, Dahong Li
Publikováno v:
Redox Biology, Vol 34, Iss , Pp 101564- (2020)
Hydrogen sulfide (H2S) is considered as a novel second-messenger molecule associated with the modulation of various physiological and pathological processes. In the field of antitumor research, endogenous H2S induces angiogenesis, accelerates the cel
Externí odkaz:
https://doaj.org/article/2f2ce73ec0e14521943a3b9441d994e5
Autor:
Ningbo Qin, Xu Hu, Shengge Li, Jian Wang, Zhanlin Li, Dahong Li, Fanxing Xu, Ming Gao, Huiming Hua
Publikováno v:
Journal of Functional Foods, Vol 38, Iss , Pp 168-179 (2017)
In the present study, the hypoglycemic effect of silychristin A on streptozotocin (STZ)-induced type 1 diabetes in rats was evaluated and the underlying pharmacological mechanism was further elucidated in vitro. Silychristin A significantly lowered t
Externí odkaz:
https://doaj.org/article/e2d0ec31a71b4e6fbec002ad63662991
Autor:
Qinxue Jing, Xu Hu, Yanzi Ma, Jiahui Mu, Weiwei Liu, Fanxing Xu, Zhanlin Li, Jiao Bai, Huiming Hua, Dahong Li
Publikováno v:
Marine Drugs, Vol 17, Iss 7, p 384 (2019)
Marine natural products are considered to be valuable resources that are furnished with diverse chemical structures and various bioactivities. To date, there are seven compounds derived from marine natural products which have been approved as therape
Externí odkaz:
https://doaj.org/article/db5e64d0f5654442b18f7f81c0be4c6b