FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma

Autor: Guangbing Zhang, Cuiyu Guo, Yan Wang, Xianda Zhang, Shuang Liu, Wen Qu, Chunxia Chen, Lingli Yan, Zhouning Yang, Zhixiong Zhang, Xiaohua Jiang, Xiaofeng Chen, Hong Liu, Qinhuai Lai, Xian Wei, Ying Lu, Shengyan Zhao, Han Deng, Yuxi Wang, Lin Yu, Hongbin Yu, Yu Wu, Zhaoming Su, Pengyu Chen, Ziqing Ren, Meng Yu, Feng Qu, Yong Luo, Lantu Gou, Qing Li, Ying Huang, Fanxin Ma, Jinliang Yang

Publikováno v: Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-6 (2022)

Abstract Anti-CD38 monoclonal antibodies (mAbs), daratumumab, and isatuximab have represented a breakthrough in the treatment of multiple myeloma (MM). Recently, CD38-based mAbs were expected to achieve increasing potential beyond MM, which encourage

Externí odkaz: https://doaj.org/article/a39a57a1992548e1beadb485c54a357e

Effective antitumor activity of 5T4-specific CAR-T cells against ovarian cancer cells in vitro and xenotransplanted tumors in vivo

Autor: Weirong Lai, Jamel Ali, Yiran Tao, Hanshuo Yang, Yuyin Fu, Yuqin Yao, E Dong, Ying Lu, Mengdan Wu, Jinliang Yang, Zhixiong Zhang, Lantu Gou, Guangbing Zhang, Yujia Peng, Cuiyu Guo, Qinhuai Lai, Shijie Zhou, Fanxin Ma, Xiaozhu Yue

Publikováno v: MedComm

Ovarian cancer is considered to be the most lethal gynecologic malignancy, and despite the development of conventional therapies and new therapeutic approaches, the patient's survival time remains short because of tumor recurrence and metastasis. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fec0ce3e1434f5bc62710a35023789e
https://pubmed.ncbi.nlm.nih.gov/34766126

Structural and Functional Characterization of Two Alternative Splicing Variants of Mouse Endothelial Cell-Specific Chemotaxis Regulator (ECSCR)

Autor: Hanju Huang, James Balducci, Yongchang Chang, Wen Wu, Hong Long Ji, Chunwei Shi, Yao Huang, Fanxin Ma

Publikováno v: International Journal of Molecular Sciences
Volume 13
Issue 4
Pages 4920-4936
International Journal of Molecular Sciences, Vol 13, Iss 4, Pp 4920-4936 (2012)

Endothelial cells (ECs) that line the lumen of blood vessels are important players in blood vessel formation, and EC migration is a key component of the angiogenic process. Thus, identification of genes that are specifically or preferentially express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8967bb55646fca6d9a17102ac012627e
https://doi.org/10.3390/ijms13044920

A critical role of vascular endothelial growth factor D in zebrafish embryonic vasculogenesis and angiogenesis

Autor: Zheng Li, Yaqi Deng, Shuo Lin, Shaohua Yao, Qin Zhou, Hongxin Deng, Min Song, Fanxin Ma, Yuquan Wei, Hanshuo Yang

Publikováno v: Biochemical and Biophysical Research Communications. 357:924-930

The VEGF family comprises seven members that are designated VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, placental growth factor (PlGF), and VEGF-F. Of these factors, VEGF-D plays important roles for angiogenesis and lymphangiogenesis, and could promote t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d18f833a2a5beeeebd59cbd5ee6bef
https://doi.org/10.1016/j.bbrc.2007.04.033

Bupivacaine causes cytotoxicity in mouse C2C12 myoblast cells: involvement of ERK and Akt signaling pathways

Autor: Fanxin Ma, Yao Huang, Joseph M Maurice, Yongchang Chang, Yan Gan, M. Hibner

Publikováno v: Acta pharmacologica Sinica. 31(4)

The adverse effects of local anesthetics (LAs) on wound healing at surgical sites have been suggested, and may be related to their cytotoxicity. This study was aimed to compare the cellular toxicity of bupivacaine and lidocaine (two well-known LAs),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f58aef6d19c1e2db504d60871c2503
https://pubmed.ncbi.nlm.nih.gov/20228829