Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology

Autor: Foulon, M, Robbe-Saule, M, Manry, J, Esnault, L, Boucaud, Y, Alcaïs, A, Malloci, M, Fanton D’andon, M, Beauvais, T, Labarrière, Nathalie, Jeannin, P, Abel, L, Saint-André, J, Croué, A, Delneste, Y, Boneca, I, Marsollier, L, Marion, E

Publikováno v: PLoS Pathogens, Vol 16, Iss 12, p e1009107 (2020)
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2020, 16 (12), pp.e1009107. ⟨10.1371/journal.ppat.1009107⟩
PLoS Pathogens, 2020, 16 (12), pp.e1009107. ⟨10.1371/journal.ppat.1009107⟩

Mycolactone, a lipid-like toxin, is the major virulence factor of Mycobacterium ulcerans, the etiological agent of Buruli ulcer. Its involvement in lesion development has been widely described in early stages of the disease, through its cytotoxic and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::17959ebffa5f7aad4c47d9c46503444f
https://doaj.org/article/26fab30b4fad432fbb1b607efbcf8b1a

Constitutive expression of terminal deoxynucleotidyl transferase in transgenic mice is sufficient for N region diversity to occur at any Ig locus throughout B cell differentiation

Autor: La, Bentolila, Ge, Wu, Nourrit F, Fanton d'Andon M, Rougeon F, Doyen N

Publikováno v: Europe PubMed Central

N region diversity in Ag receptors is a developmentally regulated process in B and T cells that correlates with the differential expression of terminal deoxynucleotidyl transferase (TdT). Absent in fetal and newborn mice, TdT expression is restricted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::77d3b1e34e930ebb93919417a007bda9
https://pubmed.ncbi.nlm.nih.gov/8992987

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Three lymphoid-specific factors account for all junctional diversity characteristic of somatic assembly of T-cell receptor and immunoglobulin genes.

Autor: Kallenbach, S, Doyen, N, Fanton d'Andon, M, Rougeon, F

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; April 1992, Vol. 89 Issue: 7 p2799-2803, 5p

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