Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808

Autor: Joseph C. Walsh, A. Katrin Szardenings, Min-Ying Su, Shadfar Bahri, Hartmuth C. Kolb, William R. Shankle, Arkadij M. Elizarov, David Chien, Alan J. Lerner, Chunfang Xia, Fanrong Mu

Publikováno v: Chien, DT; Szardenings, AK; Bahri, S; Walsh, JC; Mu, F; Xia, C; et al.(2014). Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808. Journal of Alzheimer's Disease, 38(1), 171-184. doi: 10.3233/JAD-130098. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7q6232fs
Journal of Alzheimer's disease : JAD, vol 38, iss 1

Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have recently reported early clinical results of a novel PHF-tau targeting PET imaging agent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7af0e1568c9724a1f73ba60891db3df
https://doi.org/10.3233/jad-130098

Evaluation of [18F]-CP18 as a PET Imaging Tracer for Apoptosis

Autor: Qianwa Liang, Luis F. Gomez, Joseph C. Walsh, Hartmuth C. Kolb, Fanrong Mu, A. Katrin Szardenings, Helen Su, Chunfang Xia, Gang Chen, Vani P. Mocharla, Umesh B. Gangadharmath, Chul Yu

Publikováno v: Molecular Imaging and Biology. 15:739-747

We identified and validated [18F]-CP18, a DEVD (the caspase 3 substrate recognition motif) containing substrate-based compound as an imaging tracer for caspase-3 activity in apoptotic cells. CP18 was radiolabeled with fluorine-18 using click chemistr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcc5cff99ec4ce939a1db50be39b2e1
https://doi.org/10.1007/s11307-013-0644-9

Noninvasive Molecular Imaging of Apoptosis in a Mouse Model of Anthracycline-Induced Cardiotoxicity

Autor: Natalia Gorodny, Fanrong Mu, Joseph C. Walsh, Balaji Tamarappoo, Hartmuth C. Kolb, Gang Chen, Umesh B. Gangadharmath, Helen Su, Luis F. Gomez, Katrin Szardenings

Publikováno v: Circulation: Cardiovascular Imaging. 8

Background— Anthracycline-induced cardiotoxicity and myocardial dysfunction may be associated with apoptosis. Caspase 3 catalyzes a terminal step in apoptosis, and its expression may serve as a marker of cardiomyocyte apoptosis. We synthesized 18F-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d931124bfd4313aeb06dfdd907ea9e98
https://doi.org/10.1161/circimaging.114.001952

Design, Synthesis, and Biological Evaluation of a Series of Lavendustin A Analogues That Inhibit EGFR and Syk Tyrosine Kinases, as Well as Tubulin Polymerization

Autor: T E Hamel, Stephanie L. Coffing, Robert L. Geahlen, D J Riese nd, Fanrong Mu, J Johnson, Mark Cushman, P Verdier-Pinard

Publikováno v: Journal of Medicinal Chemistry. 44:441-452

A series of N-alkylamide analogues of the lavendustin A pharmacophore were synthesized and tested for inhibition of the epidermal growth factor receptor (EGFR) protein tyrosine kinase and the nonreceptor protein tyrosine kinase Syk. Although several

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b60b6952c69d720a2e56d946be17945
https://doi.org/10.1021/jm000387g

Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807

Autor: David T. Chien, Shadfar Bahri, A. Katrin Szardenings, Joseph C. Walsh, Fanrong Mu, Min-Ying Su, William R. Shankle, Arkadij Elizarov, Hartmuth C. Kolb

Publikováno v: Journal of Alzheimer's disease : JAD. 34(2)

Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have developed a novel PHF-tau targeting positron emission tomography imaging agent, [F-18]-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40aa87c75092484a255d625cddbdca95
https://pubmed.ncbi.nlm.nih.gov/23234879