Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Fanny S Krebs"'
Autor:
Stéphanie Bibert, Mathieu Quinodoz, Sylvain Perriot, Fanny S. Krebs, Maxime Jan, Rita C. Malta, Emilie Collinet, Mathieu Canales, Amandine Mathias, Nicole Faignart, Eliane Roulet-Perez, Pascal Meylan, René Brouillet, Onya Opota, Leyder Lozano-Calderon, Florence Fellmann, Nicolas Guex, Vincent Zoete, Sandra Asner, Carlo Rivolta, Renaud Du Pasquier, Pierre-Yves Bochud
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Encephalitis is a rare and potentially fatal manifestation of herpes simplex type 1 infection. Following genome-wide genetic analyses, we identified a previously uncharacterized and very rare heterozygous variant in the E3 ubiquitin ligase W
Externí odkaz:
https://doaj.org/article/d87fb10f72004b578992242a02fb6927
Autor:
Simon Burgermeister, Simona Stoykova, Fanny S. Krebs, Vincent Zoete, Martial Mbefo, Kristof Egervari, Antoine Reinhard, Bettina Bisig, Ekkehard Hewer
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6518 (2024)
Mutations affecting codon 172 of the isocitrate dehydrogenase 2 (IDH2) gene define a subgroup of sinonasal undifferentiated carcinomas (SNUCs) with a relatively favorable prognosis and a globally hypermethylated phenotype. They are also recurrent (al
Externí odkaz:
https://doaj.org/article/d740a654ee3548f89d3c9aea31bcbaca
Autor:
Fanny S. Krebs, Christian Britschgi, Sylvain Pradervand, Rita Achermann, Petros Tsantoulis, Simon Haefliger, Andreas Wicki, Olivier Michielin, Vincent Zoete
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract The BRAF kinase is attracting a lot of attention in oncology as alterations of its amino acid sequence can constitutively activate the MAP kinase signaling pathway, potentially contributing to the malignant transformation of the cell but at
Externí odkaz:
https://doaj.org/article/60b39239970549fcb6127971e1b9f683
Autor:
Fanny S. Krebs, Vincent Zoete, Maxence Trottet, Timothée Pouchon, Christophe Bovigny, Olivier Michielin
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-9 (2021)
Swiss-PO is a new web tool to map gene mutations on the 3D structure of corresponding proteins and to intuitively assess the structural implications of protein variants for precision oncology. Swiss-PO is constructed around a manually curated databas
Externí odkaz:
https://doaj.org/article/702e48919089478d814315a34c38440a
α,α-Difluorophosphonohydroxamic Acid Derivatives among the Best Antibacterial Fosmidomycin Analogues
Autor:
Aurore Dreneau, Fanny S. Krebs, Mathilde Munier, Chheng Ngov, Denis Tritsch, Didier Lièvremont, Michel Rohmer, Catherine Grosdemange-Billiard
Publikováno v:
Molecules, Vol 26, Iss 16, p 5111 (2021)
Three α,α-difluorophosphonate derivatives of fosmidomycin were synthesized from diethyl 1,1-difluorobut-3-enylphosphonate and were evaluated on Escherichia coli. Two of them are among the best 1-deoxy-d-xylulose 5-phosphate reductoisomerase inhibit
Externí odkaz:
https://doaj.org/article/3e48f6984b8f4b89a51ff7369df684dc
Autor:
Fanny S. Krebs, Camille Gérard, Alexandre Wicky, Veronica Aedo-Lopez, Edoardo Missiaglia, Bettina Bisig, Mounir Trimech, Olivier Michielin, Krisztian Homicsko, Vincent Zoete
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 8021 (2020)
We report a case of an uveal melanoma patient with GNAQ p.Gly48Leu who responded to MEK inhibition. At the time of the molecular analysis, the pathogenicity of the mutation was unknown. A tridimensional structural analysis showed that Gαq can adopt
Externí odkaz:
https://doaj.org/article/8b601cb30f094e7ea5e5472d01ca60e2
Autor:
Ángel F. Álvarez-Prado, Roeltje R. Maas, Klara Soukup, Florian Klemm, Mara Kornete, Fanny S. Krebs, Vincent Zoete, Sabina Berezowska, Jean-Philippe Brouland, Andreas F. Hottinger, Roy T. Daniel, Monika E. Hegi, Johanna A. Joyce
Publikováno v:
Cell Reports Medicine. 4:100900
Autor:
Veronica Aedo-Lopez, Bettina Bisig, Alexandre Wicky, Olivier Michielin, Mounir Trimech, Camille L. Gerard, Fanny S Krebs, Krisztian Homicsko, Edoardo Missiaglia, Vincent Zoete
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8021, p 8021 (2020)
International Journal of Molecular Sciences
International journal of molecular sciences, vol. 21, no. 21, pp. E8021
Volume 21
Issue 21
International Journal of Molecular Sciences
International journal of molecular sciences, vol. 21, no. 21, pp. E8021
Volume 21
Issue 21
We report a case of an uveal melanoma patient with GNAQ p.Gly48Leu who responded to MEK inhibition. At the time of the molecular analysis, the pathogenicity of the mutation was unknown. A tridimensional structural analysis showed that G&alpha
q
q
Publikováno v:
Journal of Computer-Aided Molecular Design
Journal of Computer-Aided Molecular Design, Springer Verlag, 2019, 33 (10), pp.927-940. ⟨10.1007/s10822-019-00229-5⟩
Journal of Computer-Aided Molecular Design, 2019, 33 (10), pp.927-940. ⟨10.1007/s10822-019-00229-5⟩
Journal of Computer-Aided Molecular Design, Springer Verlag, 2019, 33 (10), pp.927-940. ⟨10.1007/s10822-019-00229-5⟩
Journal of Computer-Aided Molecular Design, 2019, 33 (10), pp.927-940. ⟨10.1007/s10822-019-00229-5⟩
Proteins of the independent mevalonate pathway for isoprenoid biosynthesis are important targets for the development of new antibacterial compounds as this pathway is present in most pathogenic organisms such as Mycobacterium tuberculosis, DPlasmodiu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8599917a495d33408fe2e316174e51f4
https://hal.archives-ouvertes.fr/hal-02388666
https://hal.archives-ouvertes.fr/hal-02388666
Autor:
Andréa Hemmerlin, Jérémy Esque, Fanny S. Krebs, Denis Tritsch, Roland H. Stote, Mathilde Munier, Catherine Grosdemange-Billiard, Michel Rohmer
Publikováno v:
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2017, 25 (2), pp.684-689. ⟨10.1016/j.bmc.2016.11.040⟩
Bioorganic and Medicinal Chemistry Letters, 2017, 25 (2), pp.684-689. ⟨10.1016/j.bmc.2016.11.040⟩
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2017, 25 (2), pp.684-689
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2017, 25 (2), pp.684-689. ⟨10.1016/j.bmc.2016.11.040⟩
Bioorganic and Medicinal Chemistry Letters, 2017, 25 (2), pp.684-689. ⟨10.1016/j.bmc.2016.11.040⟩
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2017, 25 (2), pp.684-689
Hydroxamate analogs of fosfoxacin, the phosphate homolog of fosmidomycin, have been synthesized and their activity tested on Escherichia coli and Mycobacterium smegmatis DXRs. Except for compound 4b, the IC50 values of phosphate derivatives are appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4227fab19ce71c3e6d23865a599330