Wide reference databases for typing Trypanosoma cruzi based on amplicon sequencing of the minicircle hypervariable region.

Autor: Fanny Rusman, Anahí G Díaz, Tatiana Ponce, Noelia Floridia-Yapur, Christian Barnabé, Patricio Diosque, Nicolás Tomasini

Publikováno v: PLoS Neglected Tropical Diseases, Vol 17, Iss 11, p e0011764 (2023)

BackgroundTrypanosoma cruzi, the etiological agent of Chagas Disease, exhibits remarkable genetic diversity and is classified into different Discrete Typing Units (DTUs). Strain typing techniques are crucial for studying T. cruzi, because their DTUs

Externí odkaz: https://doaj.org/article/7912b29c02144d2fbb2fd0261dd430d4

Evidence of hybridization, mitochondrial introgression and biparental inheritance of the kDNA minicircles in Trypanosoma cruzi I.

Autor: Fanny Rusman, Noelia Floridia-Yapur, Paula G Ragone, Patricio Diosque, Nicolás Tomasini

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007770 (2020)

BACKGROUND:Genetic exchange in Trypanosoma cruzi is controversial not only in relation to its frequency, but also to its mechanism. Parasexual genetic exchange has been proposed based on laboratory hybrids, but population genomics strongly suggests m

Externí odkaz: https://doaj.org/article/2f81c86f608049cc87dab4a6c0fa7bf9

A Novel Genotype and First Record of Trypanosoma lainsoni in Argentina

Autor: Anahí G. Díaz, Paula G. Ragone, Fanny Rusman, Noelia Floridia-Yapur, Rubén M. Barquez, M. Mónica Díaz, Nicolás Tomasini, Patricio Diosque

Publikováno v: Pathogens, Vol 9, Iss 9, p 731 (2020)

Trypanosomes are a group of parasitic flagellates with medical and veterinary importance. Despite many species having been described in this genus, little is known about many of them. Here, we report a genetic and morphological characterization of tr

Externí odkaz: https://doaj.org/article/3ae905a179034dd98abf399de9e70962

Guide RNA Repertoires in the Main Lineages of Trypanosoma cruzi: High Diversity and Variable Redundancy Among Strains

Autor: Noelia Floridia-Yapur, Nicolás Tomasini, Fanny Rusman, Patricio Diosque

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

Trypanosoma cruzi, as other kinetoplastids, has a complex mechanism of editing of mitochondrial mRNAs that requires guide RNAs (gRNAs) coded in DNA minicircles in the kinetoplast. There are many variations on this mechanism among species. mRNA editin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef8e0a5f3412702e9cfea4472083e3d
https://doi.org/10.3389/fcimb.2021.663416

Evidence of hybridization, mitochondrial introgression and biparental inheritance of the kDNA minicircles in Trypanosoma cruzi I

Autor: Paula G. Ragone, Noelia Floridia-Yapur, Fanny Rusman, Patricio Diosque, Nicolás Tomasini

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007770 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Neglected Tropical Diseases

Background Genetic exchange in Trypanosoma cruzi is controversial not only in relation to its frequency, but also to its mechanism. Parasexual genetic exchange has been proposed based on laboratory hybrids, but population genomics strongly suggests m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515fc74f3ae3a2ecb610f5658404e87c
https://doaj.org/article/2f81c86f608049cc87dab4a6c0fa7bf9