Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Fanny Norris"'
Autor:
Henrik Vestergaard, Kjeld Norris, Argyrios N. Theofilopoulos, Oluf Pedersen, Dwight H. Kono, Fanny Norris, Niels Møller
Publikováno v:
FEBS Letters. 415:243-248
Protein-tyrosine phosphatases (PTPs) are key regulators of the insulin receptor signal transduction pathway. We have performed a detailed analysis of PTP expression in the major human insulin target tissues or cells (liver, adipose tissue, skeletal m
Autor:
Ole Hvilsted Olsen, Fanny Norris, Søren E. Bjørn, Kjeld Norris, Ole Nordfang, Lars Christian Petersen
Publikováno v:
European Journal of Biochemistry. 235:310-316
Tissue-factor-pathway inhibitor (TFPI) is a multivalent inhibitor with three tandemly arranged Kunitz- type-protease-inhibitor (KPI) domains. Previous studies [Girard, Y. J., Warren, L. A., Novotny , W. F., Likert, K. M., Brown, S. G., Miletich, J. R
Autor:
Karine Merigeau, Kjeld Norris, Lars Christian Petersen, Bernadette Arnoux, Pedro Saludjian, Arnaud Ducruix, Ole Hvilsted Olsen, Søren E. Bjørn, Fanny Norris
Publikováno v:
Journal of Molecular Biology. 246:609-617
The C-terminal Kunitz-type domain from the alpha 3 chain of human type VI collagen (C5), a single 58 amino acid residue chain with three disulfide bridges, was cloned, expressed and crystallized in a monoclonic form, space group P2(1), with a = 25.7
Autor:
Donald C. Foster, Lars Christian Petersen, Cindy A. Sprecher, Fanny Norris, Kjeld Norris, Søren E. Bjørn
Publikováno v:
FEBS Letters. 338:53-57
The Kunitz-type protease inhibitor domain from a recently identified homolog of the Alzheimer amyloid precursor protein (APPH KPI) was expressed in yeast, purified and characterized. Its inhibition profile towards several serine proteases was studied
Autor:
Bernadette Arnoux, Karine Merigeau, Kjeld Norris, Fanny Norris, Arnaud Ducruix, David Perahia
Publikováno v:
Acta crystallographica. Section D, Biological crystallography. 54(Pt 3)
The recombinant Kunitz-type domain (C5) of human collagen α3(VI) chain was previously described at 1.6 Å resolution at room temperature. By changing the crystallization conditions and using synchrotron radiation, we are able to record diffraction d
Autor:
Gloria Grimm, Patrick J. O'Hara, Francis J. Grant, Cindy A. Sprecher, Fanny Norris, Kjeld Norris, Donald C. Foster
Publikováno v:
Biochemistry. 32(17)
Alzheimer's disease is a degenerative neurological disorder characterized by neural loss and brain lesions associated with plaques containing large amounts of the beta/A4 amyloid peptide. Molecular cloning of the cDNA for this peptide from human brai
Autor:
Søren E. Bjørn, Kjeld Norris, Per Franklin Nielsen, Lars Thim, Mogens Christensen, Fanny Norris, Jørgen Petersen
Publikováno v:
FEBS letters. 318(3)
Recombinant human spasmolytic polypeptide (r-hSP) has been produced in relatively large amounts in Saccharomyces cerevisiae. The two intronless trefoil domains of the hSP-DNA were cloned separately by PCR from human genomic DNA, and the remaining par
Autor:
J. Brange, Ulla Ribel, J. F. Hansen, L. Snel, M. T. Hansen, S. Havelund, A.R. Sørensen, H. O. Voigt, Fanny Norris, K. Norris, G. Dodson, S. G. Melberg
Publikováno v:
Nature. 333:679-682
The use of insulin as an injected therapeutic agent for the treatment of diabetes has been one of the outstanding successes of modern medicine. The therapy has, however, had its associated problems, not least because injection of insulin does not lea
Autor:
Anette Wind, Kjeld A. Marcker, Kjeld Norris, Esper Boel, Jens Vuust, Fanny Norris, Jens F. Rehfeld
Publikováno v:
Proceedings of the National Academy of Sciences. 80:2866-2869
An oligo(dT)-primed cDNA copy of the mRNA coding for the human gastrin precursor was constructed from poly(A)-containing RNA from a human pancreatic, gastrin-producing tumor (a gastrinoma). The cDNA was inserted into the Pst I endonuclease site of pl
Publikováno v:
FEBS Letters. 212:302-306
Saccharomyces cerevisiae strains were transformed with plasmids coding for modified mating factor alpha 1 leader sequences followed by glucagon. Glucagon-containing peptides which were secreted into the fermentation broth were isolated and their amin