Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Fanny M. Ebling"'
Publikováno v:
The Journal of Immunology. 178:7649-7657
Systemic lupus erythematosus is an autoimmune disease caused by autoantibodies, including IgG anti-DNA. New Zealand Black/New Zealand White F1 female mice, a model of spontaneous polygenic systemic lupus erythematosus, tolerized with an artificial pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3246c170e5641d88d1c410b25bcba631
https://doi.org/10.4049/jimmunol.178.12.7649
https://doi.org/10.4049/jimmunol.178.12.7649
Publikováno v:
Autoimmunity Reviews. 4:515-519
Production of autoantibodies by B cells in systemic lupus erythematosus (SLE) can be interrupted via induction of regulatory and suppressor T cells. We have used the strategy of tolerizing lupus-prone (NZBxNZW)F(1) mice with an artificial peptide bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12e27ab1b2d2220bd01dc6e911aff77
https://doi.org/10.1016/j.autrev.2005.04.008
https://doi.org/10.1016/j.autrev.2005.04.008
Publikováno v:
Annals of the New York Academy of Sciences. 1051:433-441
The hyperactive interaction between helper T cells and autoimmune B cells in individuals predisposed to systemic lupus erythematosus (SLE) can be interrupted by induction of regulatory and suppressor T cells. Using two strategies-high dose tolerance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e8b536fb33841bd7944fe44f5c9fc1
https://doi.org/10.1196/annals.1361.085
https://doi.org/10.1196/annals.1361.085
Publikováno v:
APLAR Journal of Rheumatology. 7:3-10
Aim: Inherent in vivo cytokine milieu may help protect normal subjects from developing clinical autoimmunity, whereas changes in cytokine milieu may contribute to the development of lupus-like autoimmunity. Method: Here, we measured circulating level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a063c5e93e1d6215c6089e033847ccae
https://doi.org/10.1111/j.1479-8077.2004.00061.x
https://doi.org/10.1111/j.1479-8077.2004.00061.x
Autor:
Gunda Herberth, Fanny M. Ebling, D Langnickel, Sven Langer, Betty P. Tsao, Andreas Radbruch, Falk Hiepe, George Karpouzas, Gabriela Riemekasten, Bevra H. Hahn, Jatinderpal Kalsi, Peter Henklein, Gerd-R. Burmester
Publikováno v:
Arthritis & Rheumatism. 48:475-485
Objective The C-terminal peptide of amino acids 83–119 of the SmD1 protein is a target of the autoimmune response in human and murine lupus. This study was undertaken to test the hypothesis that SmD183–119-reactive T cells play a crucial role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8947c51be38e788be4abbd1d55d3529
https://doi.org/10.1002/art.10762
https://doi.org/10.1002/art.10762
Autor:
D. Alves Albuquerque, Vipin Kumar, Vijay Saxena, Bevra H. Hahn, Fanny M. Ebling, Ram Singh, Tony N. Marion, Edward H. Giannini, Fred D. Finkelman
Publikováno v:
The Journal of Immunology. 169:587-594
Many individuals develop a single or a few brief episodes of autoimmunity from which they recover. Mechanisms that quell pathologic autoimmunity following such a breakdown of self-tolerance are not clearly understood. In this study, we show that in n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46766b2bcef54bcd19cdeaaebe1d46bd
https://doi.org/10.4049/jimmunol.169.1.587
https://doi.org/10.4049/jimmunol.169.1.587
Publikováno v:
Arthritis & Rheumatism. 44:432-441
Objective To test the hypothesis that an artificial peptide, based on an algorithm describing T cell stimulatory sequences from the VH regions of murine IgG antibodies to DNA, is an effective tolerogen in vivo in the (NZB/NZW)F1 (BWF1) mouse model of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d2e8ce48bb1e4937c8d441cd337085c
https://doi.org/10.1002/1529-0131(200102)44:2<432::aid-anr62>3.0.co
https://doi.org/10.1002/1529-0131(200102)44:2<432::aid-anr62>3.0.co
Publikováno v:
Journal of Clinical Investigation. 102:1841-1849
Individuals with systemic autoantibody-mediated diseases such as lupus have polyclonal T and B cell activation. Yet, autoantibody production is restricted to certain autoantigens. The mechanisms underlying this phenomenon remain unclear. We propose t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb17c246e640c0a92fd0c2e3afb1691
https://doi.org/10.1172/jci3872
https://doi.org/10.1172/jci3872
Autor:
Bevra H. Hahn, George Karpouzas, Ram P. Singh, Ram Singh, Jatinderpal Kalsi, Fanny M. Ebling, Antonio La Cava, Shweta Dubey
Publikováno v:
Autoimmunity Reviews. 3:615-617
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cb46c11a1d63a3763f22d317b2f42bd
https://doi.org/10.1016/j.autrev.2004.08.029
https://doi.org/10.1016/j.autrev.2004.08.029
Autor:
Ram Singh, Eli E. Sercarz, Bevra H. Hahn, Fanny M. Ebling, S. Southwood, Alessandro Sette, Vipin Kumar
Publikováno v:
The Journal of Experimental Medicine
(NZB x NZW) F1 (BWF1) mice develop spontaneous T cell autoimmunity to VH region determinants of syngeneic anti-DNA before the onset of clinical disease. In this study, we characterized the immunogenicity, MHC binding, and lymphokine secretion pattern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6daef25ccfdf85c6de4db62173f658
https://doi.org/10.1084/jem.181.6.2017
https://doi.org/10.1084/jem.181.6.2017