Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Fanny Gallix"'
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Akademický článek
An avian embryo patient-derived xenograft model for preclinical studies of human breast cancers
Autor: Loraine Jarrosson, Clélia Costechareyre, Fanny Gallix, Séverine Ciré, Fabien Gay, Olivier Imbaud, Romain Teinturier, Elisabetta Marangoni, Karine Aguéra, Céline Delloye-Bourgeois, Valérie Castellani
Publikováno v: iScience, Vol 24, Iss 12, Pp 103423- (2021)
Summary: Lack of preclinical patient-derived xenograft cancer models in which to conduct large-scale molecular studies seriously impairs the development of effective personalized therapies. We report here an in vivo concept consisting of implanting h
Externí odkaz: https://doaj.org/article/e65639efd1b04677a4ab64cc3627fbe5
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Abstract 2258: Erymethionase (methionine-gamma-lyase encapsulated into red blood cells) potentiates anti-PD-1 therapy in TNBC syngeneic mouse model
Autor: Karine Sénéchal, Sylvie Maubant, Marie Leblanc, Séverine Ciré, Fanny Gallix, Aurély Andrivon, Olivier Duchamp, Fabrice Viviani, Françoise Horand, Alexander Scheer, Vanessa BOURGEAUX
Publikováno v: Cancer Research. 79:2258-2258
Background : Anti-PD-1 immunotherapy, although efficient in several cancer indications; has shown some limitations due to the appearance of resistance mechanisms. More specifically, the overexpression of A2A receptor (adenosine receptor) on the surfa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dff311883fa2c33db73f47563049efad
https://doi.org/10.1158/1538-7445.am2019-2258
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Abstract 5827: Enzymatic combination investigation in cancer therapy
Autor: Karine Aguera, Fanny Gallix, Fabien Gay, Karine Senechal, Severine Cire, Françoise Horand, Alexander Scheer, Vanessa Bourgeaux
Publikováno v: Cancer Research. 78:5827-5827
L-asparaginase (ASNase), an enzyme currently used in combination with chemotherapy for Acute Lymphoblastic Leukemia (ALL) treatment, hydrolyzes L-asparagine (Asn) - a non-essential amino acid - into aspartic acid (Asp) and ammonia, leading to Asn rem
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f00c6d404f692dfb65ba7239ad6dc597
https://doi.org/10.1158/1538-7445.am2018-5827
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Abstract 4812: Arginine deiminase loaded in erythrocytes: a promising formulation for L-arginine deprivation therapy in cancers
Autor: Fabien Gay, Karine Aguera, Karine Senechal, Julie Bes, Anne-Marie Chevrier, Fanny Gallix, Christine Guicher, Philip Lorenzi, Vanessa Bourgeaux, Willy Berlier, Françoise Horand, Yann Godfrin
Publikováno v: Cancer Research. 76:4812-4812
Based on the asparaginase paradigm, several arginine-catabolizing enzymes have been developed for the treatment of arginine-dependent cancers (Wheatley, 2004). The arginine deiminase (ADI) enzyme catalyzes the hydrolysis of arginine (Arg) (Sugimura,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6cda06b3599f52d124070e3a29c7b89
https://doi.org/10.1158/1538-7445.am2016-4812
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Abstract 5369: Low asparagine synthetase expression and in vitro sensitivity highlights L-asparaginase potential for the treatment of aggressive lymphomas
Autor: Karine Aguera, Anne-Marie Chevrier, Alexandra Traverse-Glehen, Yann Godfrin, Willy Berlier, Fanny Gallix
Publikováno v: Cancer Research. 75:5369-5369
L-asparaginase (L-ASPA) is included in current chemotherapy regimen for the treatment of acute lymphoblastic leukemia (ALL). The sensitivity of ALL to L-ASPA has been linked to the incapacity of leukemic cells to produce their own asparagine, since t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8eb7c6c474b7b0c1da62c6715e5b4137
https://doi.org/10.1158/1538-7445.am2015-5369
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Asparagine Synthetase Expression and L-Asparaginase Sensitivity in Aggressive Lymphomas
Autor: Fanny Gallix, Anne-Marie Chevrier, Alexandra Traverse-Glehen, Gilles Salles, Karine Aguera, Yann Godfrin, Willy Berlier
Publikováno v: Blood. 124:5494-5494
L-asparaginase (L-ASPA) displays a strong clinical benefit in the treatment of acute lymphoblastic leukemia (ALL), where it is included in most of current chemotherapy regimen. L-ASPA depletes plasmatic asparagine (ASN), an amino acid essential for t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d22bab73f50a70d023e49d19a7db6d1f
https://doi.org/10.1182/blood.v124.21.5494.5494
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Abstract 5436: Potential of asparagine depletion for the treatment of bladder cancer and other urological tumors
Autor: Willy Berlier, Karine Aguera, Fanny Gallix, Fabien Gay, Gautam Borthakur, Yann Godfrin
Publikováno v: Cancer Research. 74:5436-5436
Due to asparagine synthetase (ASNS) deficiency, tumors cells auxotrophic for L-asparagine lack capability to synthesize this amino acid and depend to circulating L-asparagine for survival. Based on this rational, L-asparaginase (L-Aspa), an enzyme de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fdf7122bc098b4f89087b1d2a44b76e
https://doi.org/10.1158/1538-7445.am2014-5436
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L-Asparaginase Sensitivity and Asparagine Synthetase Expression In Primary Tumor Cells From AML Patients
Autor: Mohamed El Hamri, Yann Godfrin, Xavier Thomas, Marie-Pierre Goutagny, Karine Aguera, Fanny Gallix, Willy Berlier, Yves Bertrand
Publikováno v: Blood. 122:1423-1423
Introduction The rational of use of L-asparaginase (L-Aspa) is based on asparagine synthetase (ASNS) deficiency in leukemic cells. Its efficacy is due to its capacity to deplete plasmatic asparagine, starving the leukemic cells and subsequently inhib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9953409009096884fa3af1dd55787bc5
https://doi.org/10.1182/blood.v122.21.1423.1423
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