The melanopsin-mediated pupil response is reduced in idiopathic hypersomnia with long sleep time

Autor: Héloïse Rach, Ulker Kilic-Huck, Eve Reynaud, Laurence Hugueny, Emilie Peiffer, Virginie Roy de Belleplaine, Fanny Fuchs, Patrice Bourgin, Pierre A. Geoffroy

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract Idiopathic hypersomnia (IH), characterized by an excessive day-time sleepiness, a prolonged total sleep time on 24 h and/or a reduced sleep latency, affects 1 in 2000 individuals from the general population. However, IH remains underdiagnose

Externí odkaz: https://doaj.org/article/4f81a25b01034011aa721939098cf803

Pupillometry to differentiate idiopathic hypersomnia from narcolepsy type 1

Autor: Héloïse Rach, Eve Reynaud, Ulker Kilic‐Huck, Elisabeth Ruppert, Henri Comtet, Virginie Roy de Belleplaine, Fanny Fuchs, Eus J. W. Van Someren, Pierre A. Geoffroy, Patrice Bourgin

Publikováno v: Journal of Sleep Research. Wiley-Blackwell
Rach, H L, Reynaud, E, Kilic-Huck, U, Ruppert, E, Comtet, H, Roy de Belleplaine, V, Fuchs, F, van Someren, E J W, Geoffroy, P A & Bourgin, P 2023, ' Pupillometry to differentiate idiopathic hypersomnia from narcolepsy type 1 ', Journal of Sleep Research . https://doi.org/10.1111/jsr.13885

Idiopathic hypersomnia is poorly diagnosed in the absence of biomarkers to distinguish it from other central hypersomnia subtypes. Given that light plays a main role in the regulation of sleep and wake, we explored the retinal melanopsin-based pupil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3fd3370152a0682b7074222fe663eee
https://doi.org/10.1111/jsr.13885

Slow Wave Sleep Deficits in the Flinders Sensitive Line Rodent Model of Depression: Effects of Medial Forebrain Bundle Deep-Brain Stimulation

Autor: Wilf Gardner, Fanny Fuchs, Laura Durieux, Patrice Bourgin, Volker A. Coenen, Máté Döbrössy, Lucas Lecourtier

Publikováno v: Neuroscience. 498

Major Depressive Disorder (MDD) is an affective disorder typically accompanied by sleep disturbances. Deep brain stimulation (DBS) of the medial forebrain bundle (MFB) is an emerging intervention for treatment-resistant depression, but its effect on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60f6c8cf241790e815e3519c822a568
https://pubmed.ncbi.nlm.nih.gov/35750113

Dissecting and modeling photic and melanopsin effects to predict sleep disturbances induced by irregular light exposure in mice

Autor: Mio Kobayashi Frisk, Ludivine Robin-Choteau, Jessica W. Tsai, Gregor Eichele, Elisabeth Ruppert, Fanny Fuchs, L. Calvel, Jana Husse, Jeffrey Hubbard, Patrice Bourgin, Paul Franken

Publikováno v: Preoceedings of the National Academy of Sciences of the USA
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 25, pp. e2017364118

Significance Light pervasively affects physiology and behavior, especially the sleep–wake cycle (SWc), which is generated by clock signaling in the suprachiasmatic nuclei (SCN). Light synchronizes this clock and additionally exerts direct (circadia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6966216985f4d3a7ed9a4eb8dab4ba
https://hdl.handle.net/21.11116/0000-0009-778F-121.11116/0000-0009-7779-A

Melanopsin-dependent direct photic effects are equal to clock-driven effects in shaping the nychthemeral sleep-wake cycle

Autor: Patrice Bourgin, Ludivine Robin-Choteau, L. Calvel, Jana Husse, Paul Franken, Jessica W. Tsai, Jeffrey Hubbard, Fanny Fuchs, Gregor Eichele, Elisabeth Ruppert, Mio Kobayashi Frisk

Nychthemeral sleep-wake cycles (SWc) are known to be generated by the circadian clock in suprachiasmatic nuclei (SCN), entrained to the light-dark cycle. Light also exerts direct acute effects on sleep and waking. However, under longer photic exposur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7300d4dfbccfa04fe990bf68c17964