Výsledky vyhledávání - "Fanny Eysert"

Akademický článek

Mitochondrial alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks

Autor: Fanny Eysert, Paula-Fernanda Kinoshita, Julien Lagarde, Sandra Lacas-Gervais, Laura Xicota, Guillaume Dorothée, Michel Bottlaender, Frédéric Checler, Marie-Claude Potier, Marie Sarazin, Mounia Chami

Publikováno v: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-19 (2024)

Abstract Mitochondrial dysfunctions are key features of Alzheimer’s disease (AD). The occurrence of these disturbances in the peripheral cells of AD patients and their potential correlation with disease progression are underinvestigated. We studied

Externí odkaz: https://doaj.org/article/c121b4ea0df94f49962210d816a22ca2

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Akademický článek

The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer’s disease

Autor: Loan Vaillant-Beuchot, Fanny Eysert, Blandine Duval, Paula Fernanda Kinoshita, Raphaëlle Pardossi-Piquard, Charlotte Bauer, Sabiha Eddarkaoui, Luc Buée, Frédéric Checler, Mounia Chami

Publikováno v: Cell Death and Disease, Vol 15, Iss 5, Pp 1-14 (2024)

Abstract Mitochondria dysfunctions and mitophagy failure have been associated with several Alzheimer’s disease (AD) related molecular actors including amyloid beta (Aβ) and recently the amyloid precursor protein-C terminal fragments (APP-CTFs). Th

Externí odkaz: https://doaj.org/article/d57bf98a6efb4a7780bf151233e50851

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Akademický článek

Modifications of the endosomal compartment in fibroblasts from sporadic Alzheimer’s disease patients are associated with cognitive impairment

Autor: Laura Xicota, Julien Lagarde, Fanny Eysert, Benjamin Grenier-Boley, Isabelle Rivals, Alexandra Botté, Sylvie Forlani, Sophie Landron, Clément Gautier, Cecilia Gabriel, Michel Bottlaender, Jean-Charles Lambert, Mounia Chami, Marie Sarazin, Marie-Claude Potier

Publikováno v: Translational Psychiatry, Vol 13, Iss 1, Pp 1-9 (2023)

Abstract Morphological alterations of the endosomal compartment have been widely described in post-mortem brains from Alzheimer’s disease (AD) patients and subjects with Down syndrome (DS) who are at high risk for AD. Immunostaining with antibodies

Externí odkaz: https://doaj.org/article/b7f30749fb61429fb9afbbc24d6f5c53

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Akademický článek

Primary brain cell infection by Toxoplasma gondii reveals the extent and dynamics of parasite differentiation and its impact on neuron biology

Autor: Thomas Mouveaux, Emmanuel Roger, Alioune Gueye, Fanny Eysert, Ludovic Huot, Benjamin Grenier-Boley, Jean-Charles Lambert, Mathieu Gissot

Publikováno v: Open Biology, Vol 11, Iss 10 (2021)

Toxoplasma gondii is a eukaryotic parasite that forms latent cysts in the brain of immunocompetent individuals. The latent parasite infection of the immune-privileged central nervous system is linked to most complications. With no drug currently avai

Externí odkaz: https://doaj.org/article/1998a0dfa62a48d4ad61895c26541554

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Akademický článek

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

Publikováno v: EBioMedicine, Vol 9, Iss C, Pp 278-292 (2016)

Although several ADAMs (A disintegrin-like and metalloproteases) have been shown to contribute to the amyloid precursor protein (APP) metabolism, the full spectrum of metalloproteases involved in this metabolism remains to be established. Transcripto

Externí odkaz: https://doaj.org/article/b6a220c6a95c4d56a4492c3f25a412a8

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Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains

Publikováno v: Acta Neuropathologica
Acta Neuropathologica, Springer Verlag, 2020, ⟨10.1007/s00401-020-02234-7⟩

Several lines of recent evidence indicate that the amyloid precursor protein-derived C-terminal fragments (APP-CTFs) could correspond to an etiological trigger of Alzheimer’s disease (AD) pathology. Altered mitochondrial homeostasis is considered a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051591e286ab7e7e3852f18b2b4aa3bc
http://europepmc.org/articles/PMC7785558

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Mitophagy in Alzheimer's disease: Molecular defects and therapeutic approaches

Autor: Arnaud Mary, Fanny Eysert, Frédéric Checler, Mounia Chami

Publikováno v: Molecular psychiatry. 28(1)

Mitochondrial dysfunctions are central players in Alzheimer’s disease (AD). In addition, impairments in mitophagy, the process of selective mitochondrial degradation by autophagy leading to a gradual accumulation of defective mitochondria, have als

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4220e5b7af17c6170d1a31cd88a5c097
https://pubmed.ncbi.nlm.nih.gov/35665766

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Primary brain cell infection by Toxoplasma gondii reveals the extent and dynamics of parasite differentiation and its impact on neuron biology

Autor: Fanny Eysert, Jean-Charles Lambert, Alioune Gueye, Mathieu Gissot, Emmanuel Roger, Benjamin Grenier-Boley, Thomas Mouveaux, Ludovic Huot

Publikováno v: Open Biology
Open Biology, 2021, 11 (10), pp.210053. ⟨10.1098/rsob.210053⟩
Open Biology, Vol 11, Iss 10 (2021)
Open Biology, Royal Society, 2021, 11 (10), pp.210053. ⟨10.1098/rsob.210053⟩

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3a9eca1e6e2eaf7c4517b450a5649c
https://hal.science/hal-03367209

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