Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Fanny Chalmin"'
Autor:
Francois Ghiringhelli, Valentin Derangere, Marion Thibaudin, Caroline Truntzer, Bertrand Routy, Fanny Chalmin, Cédric Rébé, Julie Niogret, Hélène Berger, Romain Mary, Elise Ballot, Christophe Hibos, Léa Hampe, David Rageot, Théo Accogli, Philippe Joubert, James Harker, Frederique Vegran
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background T follicular helper cells (Tfh) are essential to shape B cell response during germinal center formation. Tfh accumulation has been reported in various human cancers, with positive or negative prognostic roles. However, the mechanisms expla
Externí odkaz:
https://doaj.org/article/eb04733954c348f69ad8e9ceaa3f46ea
Autor:
Francois Ghiringhelli, Emeric Limagne, Thomas Pilot, Aurélie Fratti, Chloé Thinselin, Anaïs Perrichet, Lucie Demontoux, Alis Ilie, Mané Ndiaye, Elise Jacquin, Carmen Garrido, Fanny Chalmin, Cédric Rébé
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background We have previously shown that 5-fluorouracil (5-FU) selectively kills myeloid-derived suppressor cells (MDSCs) and activates NLRP3 (NOD-leucine rich repeat and pyrin containing protein 3) inflammasome. NLRP3 activation leads to caspase-1 a
Externí odkaz:
https://doaj.org/article/3061d64f6a8249cd8c02b6054d7cf96f
Autor:
Angélique Chevriaux, Thomas Pilot, Valentin Derangère, Harmonie Simonin, Pierre Martine, Fanny Chalmin, François Ghiringhelli, Cédric Rébé
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The mechanisms leading to NOD-leucine rich repeat and pyrin containing protein 3 (NLRP3) inflammasome activation are still debated. It is well established that oligomerized NLRP3 interacts with apoptosis associated Speck-like protein containing a CAR
Externí odkaz:
https://doaj.org/article/660333f8abca488f866874800551f6fb
Publikováno v:
Cell Stress, Vol 3, Iss 1, Pp 9-18 (2018)
Adaptive T cell immune response is essential for tumor growth control. The efficacy of immune checkpoint inhibitors is regulated by intratumoral immune response. The tumor microenvironment has a major role in adaptive immune response tuning. Tumor ce
Externí odkaz:
https://doaj.org/article/1fe5e2a3393c487d8f27ea2c7894fda8
Autor:
Etienne Humblin, Marion Thibaudin, Fanny Chalmin, Valentin Derangère, Emeric Limagne, Corentin Richard, Richard A. Flavell, Sandy Chevrier, Sylvain Ladoire, Hélène Berger, Romain Boidot, Lionel Apetoh, Frédérique Végran, François Ghiringhelli
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Interferon regulatory factors IRF regulate lymphoid development, but the specific function of IRF8 in helper T-cell polarization is unclear. Here the authors show that IRF8 forms a complex with IRF4, PU.1 and BATF to modulate the Th9 transcription pr
Externí odkaz:
https://doaj.org/article/c89db68f04144f65900b4fd006ab4604
Autor:
Magalie Dosset, Thaiz Rivera Vargas, Anaïs Lagrange, Romain Boidot, Frédérique Végran, Aurélie Roussey, Fanny Chalmin, Lucile Dondaine, Catherine Paul, Elodie Lauret Marie-Joseph, François Martin, Bernhard Ryffel, Christophe Borg, Olivier Adotévi, François Ghiringhelli, Lionel Apetoh
Publikováno v:
OncoImmunology, Vol 7, Iss 6 (2018)
Background: Chemotherapy is currently evaluated in order to enhance the efficacy of immune checkpoint blockade (ICB) therapy in colorectal cancer. However, the mechanisms by which these drugs could synergize with ICB remains unclear. The impact of ch
Externí odkaz:
https://doaj.org/article/3108ad73e6a64718a3c8e9ecc4b0865e
Autor:
Solenne Vigne, Fanny Chalmin, Donovan Duc, Aurélie S. Clottu, Lionel Apetoh, Jean-Marc A. Lobaccaro, Isabelle Christen, Juan Zhang, Caroline Pot
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The behaviors of lymphocytes, including CD4+ T helper cells, are controlled on many levels by internal metabolic properties. Lipid metabolites have recently been ascribed a novel function as immune response modulators and perturbation of steroids pat
Externí odkaz:
https://doaj.org/article/5d2b64e780534dfdaf26a83470035993
Autor:
Hélène Bugaut, Mélanie Bruchard, Hélène Berger, Valentin Derangère, Ludivine Odoul, Romain Euvrard, Sylvain Ladoire, Fanny Chalmin, Frédérique Végran, Cédric Rébé, Lionel Apetoh, François Ghiringhelli, Grégoire Mignot
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65181 (2013)
Bleomycin (BLM) is an anticancer drug currently used for the treatment of testis cancer and Hodgkin lymphoma. This drug triggers cancer cell death via its capacity to generate radical oxygen species (ROS). However, the putative contribution of antica
Externí odkaz:
https://doaj.org/article/86b597f6dd8c41bea39c1cea84b3d20c
Autor:
Frédérique Végran, François Ghiringhelli, Lionel Apetoh, James A. Harker, Yoshihiro Urade, Antoine Bernard, Quentin Klopfenstein, Corentin Richard, Laurent Arnould, Sandy Chevrier, Romain Boidot, Etienne Humblin, Marion Thibaudin, Valentin Derangère, Emeric Limagne, Caroline Truntzer, Joséphine Melin, Christophe Hibos, Mélanie Bruchard, Théo Accogli, Fanny Chalmin, Romain Mary
T follicular helper (Tfh) cells are a subset of CD4+ T cells essential in immunity and have a role in helping B cells produce antibodies against pathogens. However, their role during cancer progression remains unknown. The mechanism of action of Tfh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8a89fd48c78846bced5b7fa3739484
https://doi.org/10.1158/2326-6066.c.6550673
https://doi.org/10.1158/2326-6066.c.6550673
Autor:
Frédérique Végran, François Ghiringhelli, Lionel Apetoh, James A. Harker, Yoshihiro Urade, Antoine Bernard, Quentin Klopfenstein, Corentin Richard, Laurent Arnould, Sandy Chevrier, Romain Boidot, Etienne Humblin, Marion Thibaudin, Valentin Derangère, Emeric Limagne, Caroline Truntzer, Joséphine Melin, Christophe Hibos, Mélanie Bruchard, Théo Accogli, Fanny Chalmin, Romain Mary
Supplementary Figure from Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ecf00c4c93b2c67a4b28cc778844e12
https://doi.org/10.1158/2326-6066.22544522
https://doi.org/10.1158/2326-6066.22544522