The Use of Hydrogel Dressings in Sulfur Mustard-Induced Skin and Ocular Wound Management

Autor: Fanny Caffin, David Boccara, Christophe Piérard

Publikováno v: Biomedicines, Vol 11, Iss 6, p 1626 (2023)

Over one century after its first military use on the battlefield, sulfur mustard (SM) remains a threatening agent. Due to the absence of an antidote and specific treatment, the management of SM-induced lesions, particularly on the skin and eyes, stil

Externí odkaz: https://doaj.org/article/101639ee79194de5ab48ec7c3e83f216

Radiation-induced changes in the glycome of endothelial cells with functional consequences

Autor: Cyprien Jaillet, Willy Morelle, Marie-Christine Slomianny, Vincent Paget, Georges Tarlet, Valérie Buard, Sonia Selbonne, Fanny Caffin, Emilie Rannou, Pierre Martinez, Agnès François, François Foulquier, Fabrice Allain, Fabien Milliat, Olivier Guipaud

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)

Abstract As it is altered by ionizing radiation, the vascular network is considered as a prime target in limiting normal tissue damage and improving tumor control in radiation therapy. Irradiation activates endothelial cells which then participate in

Externí odkaz: https://doaj.org/article/f9690215a646472da6218ce07771cc2c

Glutathione conjugates of the mercapturic acid pathway and guanine adduct as biomarkers of exposure to CEES, a sulfur mustard analog

Autor: Leslie Gudimard, David Béal, Daniel Léonço, François Fenaille, Fanny Gros-Désormeaux, Christophe Piérard, Marie Roser, Thierry Douki, Camille Eldin, Christophe Junot, Fanny Caffin

Publikováno v: Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry, Springer Verlag, 2021, 413, pp.1337-1351. ⟨10.1007/s00216-020-03096-4⟩
Analytical and Bioanalytical Chemistry, 2021, 413, pp.1337-1351. ⟨10.1007/s00216-020-03096-4⟩

Sulfur mustard (SM), a chemical warfare agent, is a strong alkylating compound that readily reacts with numerous biomolecules. The goal of the present work was to define and validate new biomarkers of exposure to SM that could be easily accessible in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8e724e94325e18e306e66cb5a42017
https://doi.org/10.1007/s00216-020-03096-4

Deep models of integrated multiscale molecular data decipher the endothelial cell response to ionizing radiation

Autor: Ian Morilla, Philippe Chan, Fanny Caffin, Ljubica Svilar, Sonia Selbonne, Ségolène Ladaigue, Valérie Buard, Georges Tarlet, Béatrice Micheau, Vincent Paget, Agnès François, Maâmar Souidi, Jean-Charles Martin, David Vaudry, Mohamed-Amine Benadjaoud, Fabien Milliat, Olivier Guipaud

Publikováno v: iScience
iScience, 2022, 25, pp.103685. ⟨10.1016/j.isci.2021.103685⟩
iScience, Vol 25, Iss 1, Pp 103685-(2022)

Summary The vascular endothelium is a hot spot in the response to radiation therapy for both tumors and normal tissues. To improve patient outcomes, interpretable systemic hypotheses are needed to help radiobiologists and radiation oncologists propos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b19a8118a64659966d28bb792627338
https://pubmed.ncbi.nlm.nih.gov/35106469

Évaluation de l’exposition à un simulant de l’Ypérite grâce aux conjugués du glutathion et à un adduit de l’ADN

Autor: Fanny Gros-Désormeaux, Marie Gilardoni, Fanny Caffin, Christophe Piérard, Thierry Douki

Publikováno v: Toxicologie Analytique et Clinique. 33:S26

Objectifs L’yperite est un toxique de guerre appartenant a la famille des vesicants causant de graves brulures cutanees, possedant une toxicite oculaire, pulmonaire et systemique. En plus des effets aigues, cet agent entraine des consequences a lon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e657ae98e15e766dbfc554e87a76329
https://doi.org/10.1016/j.toxac.2021.06.026