Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management

Autor: Fanny C.F. Ip, Yu Pong Ng, H.J. An, Ying Dai, Hai Hong Pang, Yue Qing Hu, Allison C. Chin, Calvin B. Harley, Yung Hou Wong, Nancy Y. Ip

Publikováno v: Neurosignals, Vol 22, Iss 1, Pp 52-63 (2014)

Cycloastragenol (CAG) is an aglycone of astragaloside IV. It was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. The present study demonstrates that CAG stimulates telomerase activity

Externí odkaz: https://doaj.org/article/781e1268950a4ddeafda8b6cf96d14d3

Large‐scale plasma proteomic profiling identifies a high‐performance biomarker panel for Alzheimer's disease screening and staging

Autor: Estella P.S. Tong, Henrik Zetterberg, John Hardy, Amy K.Y. Fu, Fanny C.F. Ip, Ronnie M. N. Lo, Vincent Mok, Kin Y. Mok, Andrew Lung-Tat Chan, Xiaopu Zhou, Bonnie W.Y. Wong, Kit Cheung, Yu Chen, Timothy Kwok, Nancy Y. Ip, Yuanbing Jiang, Nicole C. H. Lai, Philip C.H. Chan

Publikováno v: Alzheimer's & Dementia. 18:88-102

Introduction Blood proteins are emerging as candidate biomarkers for Alzheimer's disease (AD). We systematically profiled the plasma proteome to identify novel AD blood biomarkers and develop a high-performance, blood-based test for AD. Methods We qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b4e1247918b1ad13e268ec82ffe0a4
https://doi.org/10.1002/alz.12369

Rhynchophylline Administration Ameliorates Amyloid-β Pathology and Inflammation in an Alzheimer's Disease Transgenic Mouse Model

Autor: Guangmiao Fu, Wing Yu Fu, Amy K.Y. Fu, Shun-Fat Lau, Busma W.Y. Butt, I.C.W. Chan, Nancy Y. Ip, Fanny C.F. Ip, Vincent Wai-Hin Yuen, Kwok Wang Hung

Publikováno v: ACS chemical neuroscience. 12(22)

Alzheimer's disease (AD), the most common neurodegenerative disease, has limited treatment options. As such, extensive studies have been conducted to identify novel therapeutic approaches. We previously reported that rhynchophylline (Rhy), a small mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d004401c7329dcbd325ad20f63720b3e
https://pubmed.ncbi.nlm.nih.gov/34738783

A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice

Autor: Guangmiao Fu, Nancy Y. Ip, Choi Ying Ling, Fangyuan Kang, Fengzhi Yang, Peiran Sun, Lei Fu, Yueqing Hu, Fanny C.F. Ip, Fangzhou Xie, Kit Cheung

Publikováno v: European journal of medicinal chemistry. 226

Cholinergic neurons are ubiquitous and involved in various higher brain functions including learning and memory. Patients with Alzheimer's disease exhibit significant dysfunction and loss of cholinergic neurons. Meanwhile, such cholinergic deficits c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80103fdd936df9461deb7d5cd5247127
https://pubmed.ncbi.nlm.nih.gov/34530383

Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population

Autor: Amy K.Y. Fu, Nancy Y. Ip, Kit Cheung, John Hardy, Ronnie M. N. Lo, Xiaopu Zhou, Huan Zhong, Yolanda Yuen Tung Li, Estella P.S. Tong, Yu Chen, Yuewen Chen, Vincent Mok, Maryam Shoai, Timothy Kwok, Shuangshuang Ma, Kin Y. Mok, Ho Ko, Yulin Zhang, Fanny C.F. Ip, Yuanbing Jiang, Nicole C. H. Lai

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

Introduction Dozens of Alzheimer's disease (AD)‐associated loci have been identified in European‐descent populations, but their effects have not been thoroughly investigated in the Hong Kong Chinese population. Methods TaqMan array genotyping was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792335fec7eb3ddb818da8c918f60db7
https://doaj.org/article/79ab601c621849de94302d253f43db99