PAD4 Immunization Triggers Anti-Citrullinated Peptide Antibodies in Normal Mice: Analysis With Peptide Arrays

Autor: Marie F. Hemon, Nathalie C. Lambert, Fanny Arnoux, Jean Roudier, Isabelle Auger

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

The critical immunological event in rheumatoid arthritis (RA) is the production of antibodies to citrullinated proteins (ACPAs), ie proteins on which arginines have been transformed into citrullines by peptidyl arginine deiminases (PAD). In C3H mice,

Externí odkaz: https://doaj.org/article/3871879a9cc248b8b63483a2857a33fa

Evaluation of X Chromosome Inactivation with Respect to HLA Genetic Susceptibility in Rheumatoid Arthritis and Systemic Sclerosis.

Autor: Sami B Kanaan, Onur E Onat, Nathalie Balandraud, Gabriel V Martin, J Lee Nelson, Doua F Azzouz, Isabelle Auger, Fanny Arnoux, Marielle Martin, Jean Roudier, Tayfun Ozcelik, Nathalie C Lambert

Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0158550 (2016)

Autoimmune diseases, including rheumatoid arthritis (RA) and systemic sclerosis (SSc) are characterized by a strong genetic susceptibility from the Human Leucocyte Antigen (HLA) locus. Additionally, disorders of epigenetic processes, in particular no

Externí odkaz: https://doaj.org/article/60523377c79c49cd81c5fd6f4490636c

Comparison of Immune Response Assessment in Colon Cancer by Immunoscore (Automated Digital Pathology) and Pathologist Visual Scoring

Autor: Isabelle Boquet, Alboukadel Kassambara, Alfred Lui, Alicia Tanner, Marie Latil, Yoann Lovera, Fanny Arnoux, Fabienne Hermitte, Jérôme Galon, Aurelie Catteau

Publikováno v: Cancers; Volume 14; Issue 5; Pages: 1170

Adjunction of immune response into the TNM classification system improves the prediction of colon cancer (CC) prognosis. However, immune response measurements have not been used as robust biomarkers of pathology in clinical practice until the introdu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b30f7efa12a4007f78ad7de4c48b12
https://pubmed.ncbi.nlm.nih.gov/35267475

Mosaicism of XX and XXY cells accounts for high copy number of Toll like Receptor 7 and 8 genes in peripheral blood of men with Rheumatoid Arthritis

Autor: Cécile Mignon-Ravix, Sami B. Kanaan, Fanny Arnoux, Christophe Picard, Isabelle Auger, Doua F. Azzouz, Nathalie C. Lambert, Marielle Martin, Marina El Haddad, Nathalie Balandraud, Marie F. Hemon, Gabriel V. Martin, Jean Roudier

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.12880. ⟨10.1038/s41598-019-49309-4⟩
Scientific Reports, 2019, 9, pp.12880. ⟨10.1038/s41598-019-49309-4⟩
Scientific Reports, Nature Publishing Group, 2019, 9, pp.12880. ⟨10.1038/s41598-019-49309-4⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)

The X chromosome, hemizygous in males, contains numerous genes important to immunological and hormonal function. Alterations in X-linked gene dosage are suspected to contribute to female predominance in autoimmunity. A powerful example of X-linked do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ad3c5aa01ae404f15deca202c33c8a
https://doi.org/10.1038/s41598-019-49309-4

Newly Identified BRAF Mutation in Rheumatoid Arthritis

Autor: Fanny Arnoux, L'Houcine Ouafik, Isabelle Auger, Sami B. Kanaan, Nathalie Balandraud, Jean Roudier, Nathalie C. Lambert, Marielle Martin, Frédéric Fina

Publikováno v: Arthritis & Rheumatology. 68:1377-1383

OBJECTIVE: Rheumatoid arthritis (RA)-associated autoantibodies include those directed at the kinase site of BRAF (v-Raf murine sarcoma viral oncogene homolog B1), a serine-threonine kinase involved in the MAPK signaling pathway. To understand anti-BR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8805a0e5c96ba1e5d36b1f8bfebdfcf
https://doi.org/10.1002/art.39588