Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Fanning, Zeng"'
Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke
Autor:
Zexuan Hong, Jun Cao, Dandan Liu, Maozhu Liu, Mengyuan Chen, Fanning Zeng, Zaisheng Qin, Jigang Wang, Tao Tao
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 13, Iss 2, Pp 156-169 (2023)
Stroke is the second leading cause of death worldwide, and oxidative stress plays a crucial role. Celastrol exhibits strong antioxidant properties in several diseases; however, whether it can affect oxidation in cerebral ischemic-reperfusion injury (
Externí odkaz:
https://doaj.org/article/26dfd3556bae4eb891b6438f32f66d31
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 11, Pp 2545-2552 (2023)
Epigenetic changes in the spinal cord play a key role in the initiation and maintenance of nerve injury-induced neuropathic pain. N6-methyladenosine (m6A) is one of the most abundant internal RNA modifications and plays an essential function in gene
Externí odkaz:
https://doaj.org/article/2737c787c3e541eeab7d0261d69c8117
Autor:
Yitian Lu, Jintao Zhang, Fanning Zeng, Peng Wang, Xiangna Guo, Haitao Wang, Zaisheng Qin, Tao Tao
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-18 (2022)
Abstract Background Mesenchymal stem cell (MSCs)-derived small Extracellular Vesicles (sEVs) are considered as a new cell-free therapy for pain caused by nerve injury, but whether human placental mesenchymal stem cell-derived sEVs relieve pain in sci
Externí odkaz:
https://doaj.org/article/a4daaad836e849c49d67718e4a6a0143
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe underlying pathophysiological mechanisms of cerebral ischemia reperfusion injury (CIRI) is intricate, and current studies suggest that neuron, astrocyte, microglia, endothelial cell, and pericyte all have different phenotypic changes
Externí odkaz:
https://doaj.org/article/6b4ec5d5a5654c28b665340d2d431501
Autor:
Jiandong Liu, Xiangna Guo, Lu Yang, Tao Tao, Jun Cao, Zexuan Hong, Fanning Zeng, Yitian Lu, Chunshui Lin, Zaisheng Qin
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Celastrol plays a significant role in cerebral ischemia-reperfusion injury. Although previous studies have confirmed that celastrol post-treatment has a protective effect on ischemic stroke, the therapeutic effect of celastrol on ischemic stroke and
Externí odkaz:
https://doaj.org/article/ee3fe35379b648ad941e2b0ab7ee82c8
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Accumulating studies have indicated that propofol may lead to neurotoxicity and its effect on neural stem cells (NSCs) may play pivotal role in propofol-related neurotoxicity. Previously, we found that propofol could promote NSCs proliferation and co
Externí odkaz:
https://doaj.org/article/cd5125b9805344509d1ec080a0199c9e
Autor:
Mengyuan Chen, Maozhu Liu, Ying Luo, Jun Cao, Fanning Zeng, Lu Yang, Junqing Yang, Tao Tao, Yu Jiang
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2022 (2022)
Cerebral ischemia/reperfusion (I/R) injury is closely related to dysfunctional glucose metabolism. Celastrol is a bioactive compound that has been found to exhibit neuroprotective effects in cerebral ischemia, while whether it can protect against cer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a88b1a893333c565a52416ca9254b69
https://doi.org/10.1155/2022/7420507
https://doi.org/10.1155/2022/7420507
Autor:
Fanning Zeng, Valerie Beck, Sven Schuierer, Isabelle Garnier, Carole Manneville, Claudia Agarinis, Lapo Morelli, Lisa Quinn, Judith Knehr, Guglielmo Roma, Frederic Bassilana, Mark Nash
Publikováno v:
Cells, Vol 9, Iss 12, p 2618 (2020)
Genetic knock-in using homology-directed repair is an inefficient process, requiring the selection of few modified cells and hindering its application to primary cells. Here, we describe Homology independent gene Tagging (HiTag), a method to tag a pr
Externí odkaz:
https://doaj.org/article/207e3525506d4404aad26823f2702e3d
Lactylation is a newly found lactate-derived post-translational modification, which is firstly reported on histone protein lysine residues to regulate gene expression. Here, we provided evidence that higher serum lactate level was possibly associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33669db8d8caaa10d52ebf9b2b810141
https://doi.org/10.1101/2022.11.27.518054
https://doi.org/10.1101/2022.11.27.518054
Autor:
Jian Fang, Eun Yeong Bergsdorf, Vincent Unterreiner, Agustina La Greca, Oleksandr Dergai, Isabelle Claerr, Ngoc-Hong Luong-Nguyen, Inga Galuba, Ioannis Moutsatsos, Shinji Hatakeyama, Paul Groot-Kormelink, Fanning Zeng, Xian Zhang
Recent advances with deep neural networks have shown the feasibility of acquiring brightfield images with transmitted light and applying in-silico labeling to predict fluorescent images. We have developed a novel in-silico labeling method based on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfb5a1a731241c48e85c805d511cb953
https://doi.org/10.1101/2022.09.11.507500
https://doi.org/10.1101/2022.09.11.507500