Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen.

Autor: Fannin, RD, Gerrish, K, Sieber, SO, Bushel, PR, Watkins, PB, Paules, RS

Publikováno v: Clinical Pharmacology & Therapeutics; Apr2016, Vol. 99 Issue 4, p432-441, 10p

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α7 nicotinic receptor activation mitigates herpes simplex virus type 1 infection in microglia cells.

Autor: Chen SH; Viral Vector Core Facility, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA; Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Damborsky JC; Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Wilson BC; Viral Vector Core Facility, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA; Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Fannin RD; Molecular Genomics Core Facility, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA., Ward JM; Bioinformatics Support Group, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA., Gerrish KE; Molecular Genomics Core Facility, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA., He B; Viral Vector Core Facility, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA; Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Martin NP; Viral Vector Core Facility, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA; Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Yakel JL; Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. Electronic address: yakel@niehs.nih.gov.

Publikováno v: Antiviral research [Antiviral Res] 2024 Aug; Vol. 228, pp. 105934. Date of Electronic Publication: 2024 Jun 15.

Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity.

Autor: Letsinger AC; Neurobiology Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA., Ward JM; Bioinformatics Support Group, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA., Fannin RD; Molecular Genomics Core Facility, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA., Mahapatra D; Cellular and Molecular Pathogenesis Branch, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.; Inotiv, Research Triangle Park, NC, USA., Bridge MF; Social & Scientific Systems, Inc., a DLH Holdings Company, Durham, NC, USA., Sills RC; Cellular and Molecular Pathogenesis Branch, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA., Gerrish KE; Molecular Genomics Core Facility, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA., Yakel JL; Neurobiology Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA. yakel@niehs.nih.gov.

Publikováno v: Scientific reports [Sci Rep] 2023 Feb 04; Vol. 13 (1), pp. 2042. Date of Electronic Publication: 2023 Feb 04.

Blood gene expression profiling of an early acetaminophen response.

Autor: Bushel PR; Microarray and Genome Informatics Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.; Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA., Fannin RD; Molecular Genomics Core, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.; Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA., Gerrish K; Molecular Genomics Core, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.; Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA., Watkins PB; The Hamner Institute for Health Sciences, Research Triangle Park, NC, USA.; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA., Paules RS; Molecular Genomics Core, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.; Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

Publikováno v: The pharmacogenomics journal [Pharmacogenomics J] 2017 Jun; Vol. 17 (3), pp. 230-236. Date of Electronic Publication: 2016 Mar 01.