Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Fannie W Chen"'
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e74169 (2013)
Activation of protein kinase C (PKC) has previously been shown to ameliorate the cholesterol transport defect in Niemann Pick Type C1 (NPC1) cells, presumably by increasing the soluble levels of one of its substrates, vimentin. This activity would th
Externí odkaz:
https://doaj.org/article/b7aa6a06a22c4d90a7a8d55f022b978b
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34424 (2012)
MLN64 is an integral membrane protein localized to the late endosome and plasma membrane that is thought to function as a mediator of cholesterol transport from endosomal membranes to the plasma membrane and/or mitochondria. The protein consists of t
Externí odkaz:
https://doaj.org/article/990a19b4d98445449859cb37fc42cdf5
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15054 (2010)
Cyclodextrins (CDs) have long been used to manipulate cellular cholesterol levels both in vitro and in vivo, but their direct effects at a cellular level are not well characterized. Recently, CDs have garnered much interest because of their ability t
Externí odkaz:
https://doaj.org/article/937f5e821ba8474ebdf5072dcdbb4eb6
Autor:
Fannie W. Chen, Joanna P. Davies, Raul Calvo, Jagruti Chaudhari, Georgia Dolios, Mercedes K. Taylor, Samarjit Patnaik, Jean Dehdashti, Rebecca Mull, Patricia Dranchack, Amy Wang, Xin Xu, Emma Hughes, Noel Southall, Marc Ferrer, Rong Wang, Juan J. Marugan, Yiannis A. Ioannou
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104941- (2022)
Summary: Numerous studies have established the involvement of lysosomal and mitochondrial dysfunction in the pathogenesis of neurodegenerative disorders such as Alzheimer’s and Parkinson diseases. Building on our previous studies of the neurodegene
Externí odkaz:
https://doaj.org/article/e19a65a93a4f4b3fb15bf654a093fa23
Autor:
Fannie W. Chen, Joanna P. Davies, Raul Calvo, Jagruti Chaudhari, Georgia Dolios, Mercedes K. Taylor, Samarjit Patnaik, Jean Dehdashti, Rebecca Mull, Patricia Dranchack, Amy Wang, Xin Xu, Emma Hughes, Noel Southall, Marc Ferrer, Rong Wang, Juan J. Marugan, Yiannis A. Ioannou
Publikováno v:
iScience. 25(9)
Numerous studies have established the involvement of lysosomal and mitochondrial dysfunction in the pathogenesis of neurodegenerative disorders such as Alzheimer's and Parkinson diseases. Building on our previous studies of the neurodegenerative lyso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b92839f92dfd0817feafeb4fefb5684
https://pubmed.ncbi.nlm.nih.gov/36065186
https://pubmed.ncbi.nlm.nih.gov/36065186
Autor:
Robert A. Maue, Stephen J. Bloor, Stephen L. Sturley, Dinindu S. Senanayake, Kirill Lagutin, Katsumi Higaki, Henry N. Ginsberg, Remy T. Schneider, Natalie Hammond, Andrew B. Munkacsi, Antonio Hernandez-Ono, Nicole Dahlson, Fannie W. Chen, Daniel S. Ory, Joyce J. Repa, Yiannis A. Ioannou
Publikováno v:
Journal of Biological Chemistry. 292:4395-4410
Niemann-Pick type C (NP-C) disease is a fatal genetic lipidosis for which there is no Food and Drug Administration (FDA)-approved therapy. Vorinostat, an FDA-approved inhibitor of histone deacetylases, ameliorates lysosomal lipid accumulation in cult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f9284e1ed04dfa5c1da8744c3e7f660
https://doi.org/10.1074/jbc.m116.770578
https://doi.org/10.1074/jbc.m116.770578
Autor:
Andrew B, Munkacsi, Natalie, Hammond, Remy T, Schneider, Dinindu S, Senanayake, Katsumi, Higaki, Kirill, Lagutin, Stephen J, Bloor, Daniel S, Ory, Robert A, Maue, Fannie W, Chen, Antonio, Hernandez-Ono, Nicole, Dahlson, Joyce J, Repa, Henry N, Ginsberg, Yiannis A, Ioannou, Stephen L, Sturley
Publikováno v:
The Journal of biological chemistry. 292(11)
Niemann-Pick type C (NP-C) disease is a fatal genetic lipidosis for which there is no Food and Drug Administration (FDA)-approved therapy. Vorinostat, an FDA-approved inhibitor of histone deacetylases, ameliorates lysosomal lipid accumulation in cult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3b903d993964132afab989954c6cb21
https://pubmed.ncbi.nlm.nih.gov/28031458
https://pubmed.ncbi.nlm.nih.gov/28031458
Publikováno v:
Biochemical Journal. 390:549-561
NPC (Niemann–Pick type C) disease is a rare lipidosis characterized by the accumulation of LDL (low-density lipoprotein)-derived non-esterified cholesterol in the E/L (endosomal/lysosomal) system. The gene products that are responsible for the two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522275337b60128e432fa784f7350cf2
https://doi.org/10.1042/bj20050236
https://doi.org/10.1042/bj20050236
Autor:
Yiannis A. Ioannou, Fannie W. Chen
Publikováno v:
International Reviews of Immunology. 18:429-448
Ribosomal proteins have the complex task of coordinating protein biosynthesis to maintain cell homeostasis and survival. Recent evidence suggests that a number of ribosomal proteins have secondary functions independent of their involvement in protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1f19eec5e2943fb254d62d816b9419
https://doi.org/10.3109/08830189909088492
https://doi.org/10.3109/08830189909088492
Publikováno v:
Molecular Genetics and Metabolism. 64:271-282
Gene expression during the camptothecin-induced apoptotic death of human leukemic U937 cells and mouse T-cell hybridoma QW4.1 cells was studied by the mRNA differential display technique. Ten clones were confirmed to be differentially expressed, nine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401063256f48e416392e5e07fe0cf1a8
https://doi.org/10.1006/mgme.1998.2718
https://doi.org/10.1006/mgme.1998.2718