Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Fannie Chau"'
Autor:
Fannie Chau, Helen Y. Zou, Michele McTigue, Karlicek Shannon Marie, Kevin Ryan, Brion W. Murray, James G. Christensen, Jean Cui, Sergei Timofeevski, Gordon Alton, Jeff Xianchao Zhu
Publikováno v:
Biochemistry. 48:5339-5349
The c-Met receptor tyrosine kinase (RTK) is a key regulator in cancer, in part, through oncogenic mutations. Eight clinically relevant mutants were characterized by biochemical, biophysical, and cellular methods. The c-Met catalytic domain was highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5c208c8e92f08a0a97ca93b219f1c2
https://doi.org/10.1021/bi900438w
https://doi.org/10.1021/bi900438w
Autor:
Javier Gonzalez, Jim Nonomiya, Angelica Linton, Leena Patel, Hui Li, Fannie Chau, Hans E. Parge, Sadayappan V. Rahavendran, Heather Skor, Michael J. Hickey, Tanya Michelle Jewell, Matthew Drowns, Stephanie T. Shi, Robert P. Hunter, Cristina Lewis, Sarah Ludlum, Tatlock John H, Koleen J. Herlihy, Xiu Yu
Publikováno v:
Journal of Medicinal Chemistry. 52:1255-1258
The HCV RNA-dependent RNA polymerase has emerged as one of the key targets for novel anti-HCV therapy development. Herein, we report the optimization of the dihydropyrone series inhibitors to improve compound aqueous solubility and reduce CYP2D6 inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516b6514f4d3e027e767a1cee7f347f3
https://doi.org/10.1021/jm8014537
https://doi.org/10.1021/jm8014537
Autor:
Hongying Zhang, Robert Peralta, Stephen B. Howell, Avanish Vellanki, William G. Rice, Fannie Chau, Jeff Lightfoot, Andrea Local, Tiffany Cheng, Luis Esquivies
Publikováno v:
Blood. 126:4934-4934
APTO-253 is a novel anticancer small molecule currently in a multicenter open-label, Phase I dose escalation study in patients with relapsed or refractory hematologic malignancies. APTO-253 has potent cytotoxic activity against leukemia, lymphoma and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a689a79d206c2f71ca0e3986ed72bcbb
https://doi.org/10.1182/blood.v126.23.4934.4934
https://doi.org/10.1182/blood.v126.23.4934.4934
Autor:
Chau Doan, Javier Gonzalez, Michael J. Hickey, Joanne P. Graham, Fannie Chau, Stephanie T. Shi, Hui Li, Shella A. Fuhrman, Amy K. Patick, Xiu Yu, Cristina Lewis, Rohit Duggal, Koleen J. Herlihy, Hans E. Parge, Jingjin Gao
Publikováno v:
Antimicrobial agents and chemotherapy. 52(2)
A novel class of nonnucleoside hepatitis C virus (HCV) polymerase inhibitors characterized by a dihydropyrone core was identified by high-throughput screening. Crystallographic studies of these compounds in complex with the polymerase identified an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add56d595d6a8bf2eb4b92d6c679b9b0
https://pubmed.ncbi.nlm.nih.gov/18070954
https://pubmed.ncbi.nlm.nih.gov/18070954
Autor:
Hui Li, John Tatlock, Angelica Linton, Javier Gonzalez, Tanya Jewell, Leena Patel, Sarah Ludlum, Matthew Drowns, Sadayappan V. Rahavendran, Heather Skor, Robert Hunter, Stephanie T. Shi, Koleen J. Herlihy, Hans Parge, Michael Hickey, Xiu Yu, Fannie Chau, Jim Nonomiya, Cristina Lewis
Publikováno v:
Journal of Medicinal Chemistry; Mar2009, Vol. 52 Issue 5, p1255-1258, 4p