Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Fani Sousa"'
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2024)
Since the world first approved gene therapeutics, nucleic acid-based therapies have gained prominence. Several strategies for DNA-based therapy have been approved, and numerous clinical trials for plasmid DNA (pDNA)-based vaccines are currently in de
Externí odkaz:
https://doaj.org/article/3650c5184abc47418a092d1a1754103f
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2266 (2022)
The increasing progression of biopharmaceutical-based therapies highlights the demand for efficient chromatographic methods that can be used to purify the desired biomolecules (e.g., nucleic acids, enzymes, or monoclonal antibodies) which are present
Externí odkaz:
https://doaj.org/article/48c9e8ce97b14e3d8e2f2a8acd36b773
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Deoxyribonucleic acid (DNA) carries the genetic information essential for the growth and functioning of living organisms, playing a significant role in life sciences research. However, the long-term storage and preservation of DNA, while ensuring its
Externí odkaz:
https://doaj.org/article/ec603d14e59e419e9d83677e3c39261e
Publikováno v:
Molecules, Vol 27, Iss 5, p 1618 (2022)
Liquid chromatography plays a central role in biomanufacturing, and, apart from its use as a preparative purification strategy, either in biopharmaceuticals or in fine chemicals industries, it is also very useful as an analytical tool for monitoring,
Externí odkaz:
https://doaj.org/article/fe869a3bdbb145e0b8d65de9996828c1
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2090 (2021)
The perspective of using messenger RNA (mRNA) as a therapeutic molecule first faced some uncertainties due to concerns about its instability and the feasibility of large-scale production. Today, given technological advances and deeper biomolecular kn
Externí odkaz:
https://doaj.org/article/4504164684e44502b1d056e4b85e6ff6
Publikováno v:
Materials, Vol 14, Iss 21, p 6231 (2021)
The negligible volatility and high tunable nature of ionic liquids (ILs) have been the main drivers of their investigation in a wide diversity of fields, among which is their application in areas involving pharmaceuticals. Although most literature de
Externí odkaz:
https://doaj.org/article/415efc259aec40aab6bb45b484f71dad
Autor:
Patrícia Pereira, Augusto Q. Pedro, Márcia C. Neves, João C. Martins, Inês Rodrigues, Mara G. Freire, Fani Sousa
Publikováno v:
Life, Vol 11, Iss 10, p 1090 (2021)
High quality nucleic acids (with high integrity, purity, and biological activity) have become indispensable products of modern society, both in molecular diagnosis and to be used as biopharmaceuticals. As the current methods available for the extract
Externí odkaz:
https://doaj.org/article/41a10273c87043d692b22f03f87c6e34
Autor:
Josué Carvalho, Jéssica Lopes-Nunes, Joana Figueiredo, Tiago Santos, André Miranda, Micaela Riscado, Fani Sousa, Ana Paula Duarte, Sílvia Socorro, Cândida Teixeira Tomaz, Mafalda Felgueiras, Rui Teixeira, Conceição Faria, Carla Cruz
Publikováno v:
Sensors, Vol 21, Iss 21, p 7015 (2021)
The fast spread of SARS-CoV-2 has led to a global pandemic, calling for fast and accurate assays to allow infection diagnosis and prevention of transmission. We aimed to develop a molecular beacon (MB)-based detection assay for SARS-CoV-2, designed t
Externí odkaz:
https://doaj.org/article/46073fa94116449d9743c9201aa73dd0
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1397 (2021)
Dementia is described as the fifth leading cause of death worldwide and Alzheimer’s disease (AD) is recognized as the most common, causing a huge impact on health costs and quality of patients’ lives. The main hallmarks that are commonly associat
Externí odkaz:
https://doaj.org/article/0ae235ec460a43f68281b612541f5ead
Autor:
Patrícia Pereira, Maria Barreira, Carla Cruz, Joana Tomás, Ângelo Luís, Augusto Q. Pedro, João A. Queiroz, Fani Sousa
Publikováno v:
Pharmaceuticals, Vol 13, Iss 10, p 314 (2020)
The efficacy of brain therapeutics is largely hampered by the presence of the blood–brain barrier (BBB), mainly due to the failure of most (bio) pharmaceuticals to cross it. Accordingly, this study aims to develop nanocarriers for targeted delivery
Externí odkaz:
https://doaj.org/article/50ad08d9ee8c4e568831249a19d12463