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The Impact of Pharmacogenomics on Postoperative Nausea and Vomiting

Autor: Keith A. Candiotti, David M. Andrews, Fani Nhuch, David A. Lubarsky, Lin Wu, Aimee Kamat, David J. Birnbach, D. Michele Nikoloff, Walter H. Koch

Publikováno v: Anesthesiology. 102:543-549

Background Some patients treated with ondansetron for postoperative nausea and vomiting do not respond to therapy. One possible mechanism for this failure is ultrarapid drug metabolism via the cytochrome P-450 system, specifically the enzyme 2D6 (CYP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50f6c7fb68ee56ec68a2c3f6599acdee
https://doi.org/10.1097/00000542-200503000-00011

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Repairing interatrial septal defects from the operating room to the cardiac catheterization laboratory: 2D or not 2D?

Autor: Stanton K. Shernan, Tjorvi E. Perry, Douglas C. Shook, Henry Chou, Fani Nhuch, Wendy L. Gross

Publikováno v: Seminars in cardiothoracic and vascular anesthesia. 15(1-2)

Uncorrected congenital interatrial septal defect can be found in nearly a third of all adults and are associated with significant morbidity, including pulmonary hypertension, right-heart failure, atrial arrhythmias, and paradoxical embolic stroke. Wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f9773216386369671f03b19ac43611
https://pubmed.ncbi.nlm.nih.gov/21543363

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Granisetron versus ondansetron treatment for breakthrough postoperative nausea and vomiting after prophylactic ondansetron failure: a pilot study

Autor: Keith A. Candiotti, Kristopher L. Arheart, David A. Lubarsky, David J. Birnbach, Aimee Kamat, Krisnaprasad Deepika, Fani Nhuch

Publikováno v: Anesthesia and analgesia. 104(6)

Patients with an increased risk of postoperative nausea and vomiting (PONV) are frequently given prophylactic doses of a selective 5-hydroxytryptamine-3 antagonist (5HT3). In chemotherapy patients, it has been demonstrated that after unsuccessful tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3bed9ee827e0fe530e9e5cb2350ebe9
https://pubmed.ncbi.nlm.nih.gov/17513628

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Emergency preparedness for biological and chemical incidents: a survey of anesthesiology residency programs in the United States

Autor: Keith A. Candiotti, David J. Birnbach, David A. Lubarsky, Fani Nhuch, Aimee Kamat, Paul Barach

Publikováno v: Anesthesia and analgesia. 101(4)

UNLABELLED We surveyed health care professionals about their preparations to manage the clinical problems associated with patients exposed to hazardous substances, including weapons of mass destruction (WMD). Training for WMD is considered a key part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0795a4e2cf4a493671ccec2b81a04dd2
https://pubmed.ncbi.nlm.nih.gov/16192534

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The impact of pharmacogenomics on postoperative nausea and vomiting: do CYP2D6 allele copy number and polymorphisms affect the success or failure of ondansetron prophylaxis?

Autor: Keith A, Candiotti, David J, Birnbach, David A, Lubarsky, Fani, Nhuch, Aimee, Kamat, Walter H, Koch, Michele, Nikoloff, Lin, Wu, David, Andrews

Publikováno v: Anesthesiology. 102(3)

Some patients treated with ondansetron for postoperative nausea and vomiting do not respond to therapy. One possible mechanism for this failure is ultrarapid drug metabolism via the cytochrome P-450 system, specifically the enzyme 2D6 (CYP2D6). Ultra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b45d6ee9136e7d1ca015570e7c10ff4
https://pubmed.ncbi.nlm.nih.gov/15731591

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