Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Fangxue Yan"'
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Acute myeloid leukemia (AML) is one of the most lethal blood cancers, accounting for close to a quarter of a million annual deaths worldwide. Even though genetically heterogeneous, all AMLs are characterized by two interrelated features—blocked dif
Externí odkaz:
https://doaj.org/article/1957f60d4430415e916cdc148d37b0bc
Autor:
Hongru Zhang, Pengfei Yu, Vivek S. Tomar, Xiangjie Chen, Matthew J. Atherton, Zhen Lu, Hong-Guang Zhang, Shifeng Li, Angelica Ortiz, Jun Gui, N. Adrian Leu, Fangxue Yan, Andres Blanco, Mirella L. Meyer-Ficca, Ralph G. Meyer, Daniel P. Beiting, Jinyang Li, Selene Nunez-Cruz, Roddy S. O’Connor, Lexus R. Johnson, Andy J. Minn, Subin S. George, Constantinos Koumenis, J. Alan Diehl, Michael C. Milone, Hui Zheng, Serge Y. Fuchs
Publikováno v:
Nature Cancer. 3:808-820
Evasion of antitumor immunity and resistance to therapies in solid tumors are aided by an immunosuppressive tumor microenvironment (TME). We found that TME factors, such as regulatory T cells and adenosine, downregulated type I interferon receptor IF
Autor:
M. Andrés Blanco, David B. Sykes, Ben Z. Stanger, Benjamin A. Garcia, Fei Lan, Liling Wan, Pamela J. Sung, Sara E. Meyer, Neil Palmisiano, Susumu Rokudai, Yiman Liu, Sixiang Yu, Joshua Rico, Yuwei Qi, Janice M. Reynaga, Salina Yuan, Zhennan Shi, Suying Liu, Ricardo Petroni, Jelena Milosevic, Jinyang Li, Fangxue Yan
Supplementary Data from KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08944082e5e92778ca9637a67237bae6
https://doi.org/10.1158/2159-8290.22541249.v1
https://doi.org/10.1158/2159-8290.22541249.v1
Autor:
Serge Y. Fuchs, Dmitry I. Gabrilovich, Yulia Nefedova, Allison Berger, Gurpanna Saggu, Jose R. Conejo-Garcia, M. Andres Blanco, Daniel P. Beiting, Tara Lee Costich, Noreen McBrearty, Jun Gui, Fangxue Yan, Raghavendra Basavaraja, Jinyang Li, Vivek S. Tomar, Hongru Zhang
Supplementary Tables 1, 2, and 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546bad13fd141f8f1defa7dae784bf9e
https://doi.org/10.1158/2326-6066.22545902
https://doi.org/10.1158/2326-6066.22545902
Autor:
Ben Z. Stanger, Andrés Blanco, Taiji Yamazoe, Fangxue Yan, Robert J. Norgard, Salina Yuan, Jinyang Li
Legends for Figure S1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c273cac868928b5de9372f6bc276e0
https://doi.org/10.1158/2326-6066.22543750.v1
https://doi.org/10.1158/2326-6066.22543750.v1
Autor:
Ben Z. Stanger, Andrés Blanco, Taiji Yamazoe, Fangxue Yan, Robert J. Norgard, Salina Yuan, Jinyang Li
Although immune checkpoint blockade (ICB) improves clinical outcome in several types of malignancies, pancreatic ductal adenocarcinoma (PDA) remains refractory to this therapy. Preclinical studies have demonstrated that the relative abundance of supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983f7bd11fa278cc1ec7a12b0726e75e
https://doi.org/10.1158/2326-6066.c.6550393
https://doi.org/10.1158/2326-6066.c.6550393
Autor:
M. Andrés Blanco, David B. Sykes, Ben Z. Stanger, Benjamin A. Garcia, Fei Lan, Liling Wan, Pamela J. Sung, Sara E. Meyer, Neil Palmisiano, Susumu Rokudai, Yiman Liu, Sixiang Yu, Joshua Rico, Yuwei Qi, Janice M. Reynaga, Salina Yuan, Zhennan Shi, Suying Liu, Ricardo Petroni, Jelena Milosevic, Jinyang Li, Fangxue Yan
Epigenetic programs are dysregulated in acute myeloid leukemia (AML) and help enforce an oncogenic state of differentiation arrest. To identify key epigenetic regulators of AML cell fate, we performed a differentiation-focused CRISPR screen in AML ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137da5138aa0253a5d42c0f930caaac6
https://doi.org/10.1158/2159-8290.c.6549584.v1
https://doi.org/10.1158/2159-8290.c.6549584.v1
Autor:
Ben Z. Stanger, Andrés Blanco, Taiji Yamazoe, Fangxue Yan, Robert J. Norgard, Salina Yuan, Jinyang Li
Supplementary Figures 1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9dcb1ffed46ac4cf9daeb3229be5c5
https://doi.org/10.1158/2326-6066.22543747.v1
https://doi.org/10.1158/2326-6066.22543747.v1
Autor:
Serge Y. Fuchs, Dmitry I. Gabrilovich, Yulia Nefedova, Allison Berger, Gurpanna Saggu, Jose R. Conejo-Garcia, M. Andres Blanco, Daniel P. Beiting, Tara Lee Costich, Noreen McBrearty, Jun Gui, Fangxue Yan, Raghavendra Basavaraja, Jinyang Li, Vivek S. Tomar, Hongru Zhang
Fragility of regulatory T (Treg) cells manifested by the loss of neuropilin-1 (NRP1) and expression of IFNγ undermines the immune suppressive functions of Treg cells and contributes to the success of immune therapies against cancers. Intratumoral Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b2160ed088e90c87fe5fb79aaab1bd
https://doi.org/10.1158/2326-6066.c.6551048.v1
https://doi.org/10.1158/2326-6066.c.6551048.v1
Autor:
Serge Y. Fuchs, Dmitry I. Gabrilovich, Yulia Nefedova, Allison Berger, Gurpanna Saggu, Jose R. Conejo-Garcia, M. Andres Blanco, Daniel P. Beiting, Tara Lee Costich, Noreen McBrearty, Jun Gui, Fangxue Yan, Raghavendra Basavaraja, Jinyang Li, Vivek S. Tomar, Hongru Zhang
Supplementary Figure from Protection of Regulatory T Cells from Fragility and Inactivation in the Tumor Microenvironment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569162bd4707629449e8049aabe81276
https://doi.org/10.1158/2326-6066.22545905
https://doi.org/10.1158/2326-6066.22545905