Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Fangxia Zou"'
Autor:
Wenyan Wang, Guangying Du, Shilan Lin, Jing Liu, Huijie Yang, Dawei Yu, Liang Ye, Fangxia Zou, Hongbo Wang, Rui Zhang, Jingwei Tian
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Valbenazine and deutetrabenazine are the only two therapeutic drugs approved for tardive dyskinesia based on blocking the action of vesicular monoamine transporter 2 (VMAT2). But there exist demethylated inactive metabolism at the nine position for b
Externí odkaz:
https://doaj.org/article/515593430ba74dea8100ad61c24a8ad7
Autor:
Qiuju Dong, Pengfei Yu, Liang Ye, Jianzhao Zhang, Hongbo Wang, Fangxia Zou, Jingwei Tian, Hiroshi Kurihara
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract PCC-0208027 is a novel tyrosine kinase inhibitor that has a strong inhibitory effect on epidermal growth factor receptor (EGFR)- or HER2-driven cancers. The aim is to assess the anti-tumor activity of PCC0208027 and related mechanisms in non
Externí odkaz:
https://doaj.org/article/316acfb7beae4c10bb5699957babc6e9
Autor:
Jing Lu, Hui Lei, Xinfa Bai, Wenyan Wang, Chunjiao Liu, Yifei Yang, Fangxia Zou, Guangying Du, Xin Wang, Cuicui Sun, Lisha Yu, Mingxu Ma, Liang Ye, Hongbo Wang, Jingwei Tian, jianzhao zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0af0f7e92ffd29bde33280a56b064e1
https://doi.org/10.2139/ssrn.4329585
https://doi.org/10.2139/ssrn.4329585
Autor:
Liang Ye, Yifei Yang, Chunmei Li, Jianzhao Zhang, Wenyan Wang, Mingxu Ma, Hengwei Xu, Wenjing Zhang, Fangxia Zou, Zhengping Hu, Hongbo Wang, Jingwei Tian
Publikováno v:
European Journal of Medicinal Chemistry. 257:115486
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72e5278ae4ebfe1ec6ee745ce0477805
https://doi.org/10.1016/j.ejmech.2023.115486
https://doi.org/10.1016/j.ejmech.2023.115486
Autor:
Fangxia, Zou, Yao, Wang, Dawei, Yu, Chunjiao, Liu, Jing, Lu, Min, Zhao, Mingxu, Ma, Wenyan, Wang, Wanglin, Jiang, Yonglin, Gao, Rui, Zhang, Jianzhao, Zhang, Liang, Ye, Jingwei, Tian
Publikováno v:
European Journal of Medicinal Chemistry. 242:114679
The gonadotropin releasing hormone receptor (GnRH-R) is a G protein-coupled receptor (GPCR) belonging to the rhodopsin family. GnRH-R antagonists suppress testosterone to castrate level more rapidly than gonadotropin releasing hormone agonists but la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875f606c9ca655f67561596e3197dfdf
https://doi.org/10.1016/j.ejmech.2022.114679
https://doi.org/10.1016/j.ejmech.2022.114679
Autor:
Rui Zhang, Hongbo Wang, Jingwei Tian, Dawei Yu, Xiaoyin Zhu, Liang Ye, Wenyan Wang, Fangxia Zou, Yifei Yang, Guangying Du
Publikováno v:
European journal of medicinal chemistry. 224
Vesicular monoamine transporter 2 (VMAT2) is essential for synaptic transmission of all biogenic amines in the brain including serotonin, norepinephrine, histamine, and dopamine (DA). Given its crucial role in the neurophysiology and pharmacology of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7459e9176a67034ac1b1ea4580eabd3e
https://pubmed.ncbi.nlm.nih.gov/34329999
https://pubmed.ncbi.nlm.nih.gov/34329999
Autor:
Mingxu Ma, Yifei Yang, Guangying Du, Yusen Dai, Xiaoyin Zhu, Wenyan Wang, Hengwei Xu, Jianzhao Zhang, Lixia Zheng, Fangxia Zou, Huijie Yang, Bin Liu, Wanhui Liu, Liang Ye, Rui Zhang, Jingwei Tian
Publikováno v:
European Journal of Medicinal Chemistry. 234:114246
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4941c1d7fe7e6e3e187ad942698c8142
https://doi.org/10.1016/j.ejmech.2022.114246
https://doi.org/10.1016/j.ejmech.2022.114246
Autor:
Zhengping Hu, Liang Ye, Pengfei Yu, Jingwei Tian, Hongbo Wang, Fangxia Zou, Wenyan Wang, Xiao Chen, Guangying Du
Publikováno v:
Toxicology and applied pharmacology. 398
The non-receptor tyrosine phosphatase SHP2, encoded by PTPN11, plays an indispensable role in tumors driven by oncogenic KRAS mutations, which frequently occur in colorectal cancer. Here, PCC0208023, a potent SHP2 allosteric inhibitor, was synthesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc17a47c9f434c4f3491522d50f5ed37
https://pubmed.ncbi.nlm.nih.gov/32335126
https://pubmed.ncbi.nlm.nih.gov/32335126
Publikováno v:
Journal of Medicinal Chemistry. 61:8981-9003
Isocitrate dehydrogenases 1 and 2 (IDH1/2) are homodimeric enzymes that catalyze the conversion of isocitrate to α-ketoglutarate (α-KG) in the tricarboxylic acid cycle. However, mutant IDH1/2 (mIDH1/2) reduces α-KG to the oncometabolite 2-hydroxyg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129d1752d273498011b3ddf7fab8998a
https://doi.org/10.1021/acs.jmedchem.8b00159
https://doi.org/10.1021/acs.jmedchem.8b00159
Autor:
Tianfang Ma, Stefan Pusch, Lijun Yang, Andreas von Deimling, Yungen Xu, Xiaoming Zha, Fangxia Zou, Qihua Zhu, Yueqing Gu
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:6379-6387
Isocitrate dehydrogenases (IDHs) catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (α-KG) generating carbon dioxide and NADPH/NADH. Evidence suggests that the specific mutations in IDH1 are critical to the growth and reprod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6436a5e6b388d3df56da161cbb2f8b28
https://doi.org/10.1016/j.bmc.2017.10.009
https://doi.org/10.1016/j.bmc.2017.10.009