Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Fangtian Huang"'
Publikováno v:
Traffic. May2001, Vol. 2 Issue 5, p345. 13p.
Autor:
Manimalha Balasubramani, Xuemei Zeng, Steven P. Gygi, Nathan A. Yates, Arola Fortian, Alexander Sorkin, Fangtian Huang, Woong Kim
Publikováno v:
Proceedings of the National Academy of Sciences. 110:15722-15727
Ubiquitination mediates endocytosis and endosomal sorting of various signaling receptors, transporters, and channels. However, the relative importance of mono- versus polyubiquitination and the role of specific types of polyubiquitin linkages in endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ef50144a674c0e525c199f29d06c20
https://doi.org/10.1073/pnas.1308014110
https://doi.org/10.1073/pnas.1308014110
Publikováno v:
Traffic. 13:329-337
Progression of activated EGF receptor (EGFR) through the endocytic pathway regulates EGFR signaling. Here we show that a non-ubiquitinated EGFR mutant, unable to bind the endosomal-sorting complex required for transport (ESCRT) component, Hrs, is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5a76d37050dbc04577253178c5bab19
https://doi.org/10.1111/j.1600-0854.2011.01305.x
https://doi.org/10.1111/j.1600-0854.2011.01305.x
Publikováno v:
The Journal of Cell Biology
Four independent mechanisms for uptake of activated EGFR are identified by a combination of receptor mutagenesis and RNA interference approaches.
Endocytosis of the epidermal growth factor receptor (EGFR) is important for the regulation of EGFR
Endocytosis of the epidermal growth factor receptor (EGFR) is important for the regulation of EGFR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2be342b5426b2e36c156a05537b963
http://europepmc.org/articles/PMC2878939
http://europepmc.org/articles/PMC2878939
Publikováno v:
Proceedings of the National Academy of Sciences. 104:16904-16909
Ubiquitination of the EGF receptor (EGFR) has been implicated in EGF-induced receptor internalization, lysosomal degradation, and down-regulation. Mutation of EGFR ubiquitination sites identified by mass spectrometry yielded receptor mutants that are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e98bc74dc55d7eaa88a3e74a1f5eb3d
https://doi.org/10.1073/pnas.0707416104
https://doi.org/10.1073/pnas.0707416104
Publikováno v:
Molecular Cell. 21:737-748
Ubiquitination of the EGF receptor (EGFR) is believed to play a critical role in regulating both its localization and its stability. To elucidate the role of EGFR ubiquitination, tandem mass spectrometry was used to identify six distinct lysine resid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f6a772804531ef2ca7b7d0e8d3c9bf
https://doi.org/10.1016/j.molcel.2006.02.018
https://doi.org/10.1016/j.molcel.2006.02.018
Publikováno v:
Journal of Biological Chemistry. 277:27433-27441
Several inhibitors of epidermal growth factor receptor (EGFR) kinase and Src family kinases (SFK) were employed to study the role of these kinases in EGFR internalization through clathrin-coated pits. The EGFR kinase-specific compound PD158780 substa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13175b81b448e64d575a56be537783b2
https://doi.org/10.1074/jbc.m201595200
https://doi.org/10.1074/jbc.m201595200
Publikováno v:
Traffic. 2:345-357
Clathrin adaptor protein AP-1 complex is thought to function in forming clathrin-coated vesicles at the trans-Golgi network (TGN) and mediating transport of cargo between the TGN and endosomes. To study trafficking of AP-1 in living cells, yellow flu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb162d598fd8c6d040b290d138dc0481
https://doi.org/10.1034/j.1600-0854.2001.25020506.x
https://doi.org/10.1034/j.1600-0854.2001.25020506.x
Publikováno v:
Traffic (Copenhagen, Denmark). 13(2)
Progression of activated EGF receptor (EGFR) through the endocytic pathway regulates EGFR signaling. Here we show that a non-ubiquitinated EGFR mutant, unable to bind the endosomal-sorting complex required for transport (ESCRT) component, Hrs, is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f82ce6681d134ea96ac38cf28850457
https://pubmed.ncbi.nlm.nih.gov/22017370
https://pubmed.ncbi.nlm.nih.gov/22017370
Autor:
Alexander Sorkin, Fangtian Huang
Publikováno v:
Molecular biology of the cell. 16(3)
Knockdown of growth factor receptor binding protein 2 (Grb2) by RNA interference strongly inhibits clathrin-mediated endocytosis of the epidermal growth factor receptor (EGFR). To gain insights into the function of Grb2 in EGFR endocytosis, we have g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6964d72698da7fa1f7e9d69cfcd80860
https://pubmed.ncbi.nlm.nih.gov/15635092
https://pubmed.ncbi.nlm.nih.gov/15635092