Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Fangping Cai"'
Autor:
Fangping Cai, Wei-Hung Chen, Weimin Wu, Julia A Jones, Misook Choe, Neelakshi Gohain, Xiaoying Shen, Celia LaBranche, Amanda Eaton, Laura Sutherland, Esther M Lee, Giovanna E Hernandez, Nelson R Wu, Richard Scearce, Michael S Seaman, M Anthony Moody, Sampa Santra, Kevin Wiehe, Georgia D Tomaras, Kshitij Wagh, Bette Korber, Mattia Bonsignori, David C Montefiori, Barton F Haynes, Natalia de Val, M Gordon Joyce, Kevin O Saunders
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009624 (2021)
A primary goal of HIV-1 vaccine development is the consistent elicitation of protective, neutralizing antibodies. While highly similar neutralizing antibodies (nAbs) have been isolated from multiple HIV-infected individuals, it is unclear whether vac
Externí odkaz:
https://doaj.org/article/49af7daf7eef4bd3a19720f1036c1e68
Autor:
Bhavna Hora, Naila Gulzar, Yue Chen, Konstantinos Karagiannis, Fangping Cai, Chang Su, Krista Smith, Vahan Simonyan, Sharaf Ali Shah, Manzoor Ahmed, Ana M. Sanchez, Mars Stone, Myron S. Cohen, Thomas N. Denny, Raja Mazumder, Feng Gao
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
ABSTRACT High-throughput sequencing (HTS) has been widely used to characterize HIV-1 genome sequences. There are no algorithms currently that can directly determine genotype and quasispecies population using short HTS reads generated from long genome
Externí odkaz:
https://doaj.org/article/ad53339e65e5434399222e31b258226c
Autor:
Nelson R Wu, Nathan I Nicely, Esther M Lee, Rachel K Reed, Brian E Watts, Fangping Cai, William E Walkowicz, Baptiste Aussedat, Julia A Jones, Amanda Eaton, Ashley M Trama, S Munir Alam, David C Montefiori, Barton F Haynes, Kevin O Saunders
Publikováno v:
PLoS Pathogens, Vol 15, Iss 12, p e1008165 (2019)
Viral glycoproteins are a primary target for host antibody responses. However, glycans on viral glycoproteins can hinder antibody recognition since they are self glycans derived from the host biosynthesis pathway. During natural HIV-1 infection, neut
Externí odkaz:
https://doaj.org/article/79f34e83bc304131af0d0745c58e3159
Autor:
Hongshuo Song, Elena E. Giorgi, Vitaly V. Ganusov, Fangping Cai, Gayathri Athreya, Hyejin Yoon, Oana Carja, Bhavna Hora, Peter Hraber, Ethan Romero-Severson, Chunlai Jiang, Xiaojun Li, Shuyi Wang, Hui Li, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Nilu Goonetilleke, Brandon F. Keele, David C. Montefiori, Myron S. Cohen, George M. Shaw, Beatrice H. Hahn, Andrew J. McMichael, Barton F. Haynes, Bette Korber, Tanmoy Bhattacharya, Feng Gao
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Recombination contributes to HIV evolution in patients, but its identification can be difficult. Here, the authors develop a computational tool called RAPR to track recombination in patients, identify recombination hot spots, and show contribution of
Externí odkaz:
https://doaj.org/article/30d8c57d3c3f40a3b0cc066eb2a1b284
Autor:
Kevin O. Saunders, Nathan I. Nicely, Kevin Wiehe, Mattia Bonsignori, R. Ryan Meyerhoff, Robert Parks, William E. Walkowicz, Baptiste Aussedat, Nelson R. Wu, Fangping Cai, Yusuf Vohra, Peter K. Park, Amanda Eaton, Eden P. Go, Laura L. Sutherland, Richard M. Scearce, Dan H. Barouch, Ruijun Zhang, Tarra Von Holle, R. Glenn Overman, Kara Anasti, Rogier W. Sanders, M. Anthony Moody, Thomas B. Kepler, Bette Korber, Heather Desaire, Sampa Santra, Norman L. Letvin, Gary J. Nabel, David C. Montefiori, Georgia D. Tomaras, Hua-Xin Liao, S. Munir Alam, Samuel J. Danishefsky, Barton F. Haynes
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2175-2188 (2017)
Summary: Induction of broadly neutralizing antibodies (bnAbs) that target HIV-1 envelope (Env) is a goal of HIV-1 vaccine development. A bnAb target is the Env third variable loop (V3)-glycan site. To determine whether immunization could induce antib
Externí odkaz:
https://doaj.org/article/f020d40e9877461f93e8d9d15c7fa9e4
Autor:
Kshitij Wagh, Edward F. Kreider, Yingying Li, Hannah J. Barbian, Gerald H. Learn, Elena Giorgi, Peter T. Hraber, Timothy G. Decker, Andrew G. Smith, Marcos V. Gondim, Lindsey Gillis, Jamie Wandzilak, Gwo-Yu Chuang, Reda Rawi, Fangping Cai, Pierre Pellegrino, Ian Williams, Julie Overbaugh, Feng Gao, Peter D. Kwong, Barton F. Haynes, George M. Shaw, Persephone Borrow, Michael S. Seaman, Beatrice H. Hahn, Bette Korber
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 893-908.e7 (2018)
Summary: Densely arranged N-linked glycans shield the HIV-1 envelope (Env) trimer from antibody recognition. Strain-specific breaches in this shield (glycan holes) can be targets of vaccine-induced neutralizing antibodies that lack breadth. To unders
Externí odkaz:
https://doaj.org/article/263741a4aea942aabfd534e4a17be6c2
Autor:
Barton F. Haynes, Esther J. Lee, Mark G. Lewis, Laura L. Sutherland, Robert J. Edwards, Kevin O. Saunders, S. Munir Alam, R. Wes Rountree, Mark A. Tomai, Kartik Manne, Priyamvada Acharya, Anyway B. Kapingidza, C. Todd DeMarco, Sophie M. C. Gobeil, Maggie Barr, Robert A. Seder, Matthew Gagne, Robert Parks, Rachel L. Spreng, Dapeng Li, Gregory D. Sempowski, Aja Sanzone, Hanne Leth Andersen, Ralph S. Baric, Christopher B. Fox, Mihai L. Azoitei, Elizabeth Petzold, Thomas N. Denny, Longping V. Tse, Christopher W. Woods, David C. Montefiori, Drew Weissman, Norbert Pardi, Daniel C. Douek, Haiyan Chen, Katayoun Mansouri, David R. Martinez, Ian N. Moore, Trevor Scobey, Thomas H. Oguin, Kevin Wiehe, Madison Berry, Fangping Cai
Publikováno v:
bioRxiv
SUMMARYBetacoronaviruses (betaCoVs) caused the severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS) outbreaks, and now the SARS-CoV-2 pandemic. Vaccines that elicit protective immune responses against SARS-CoV-2 and be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7849ac2671cd4a5cdd07c8df6f443fbc
https://doi.org/10.1101/2021.02.17.431492
https://doi.org/10.1101/2021.02.17.431492
Autor:
Ian N. Moore, Priyamvada Acharya, C. Todd DeMarco, Megan Kopp, Maggie Barr, Andrew N. Macintyre, Sophie M. C. Gobeil, Chuancang Jiang, Ralph S. Baric, Alexandra Schäfer, Derek W. Cain, M. Anthony Moody, Bianca M. Nagata, David R. Martinez, Kevin W. Bock, Robert Parks, Kartik Manne, Laura L. Sutherland, Thomas N. Denny, I-Ting Teng, Victoria Gee-Lai, Giovanna Hernandez, S. Munir Alam, Margaret Deyton, Xiaozhi Lu, John R. Mascola, Dapeng Li, Aaron G. Schmidt, Lautaro G. Perez, Christopher W. Woods, Charlene McDanal, Jared Feldman, Aja Sanzone, Ken Cronin, Barney S. Graham, Katarzyna Janowska, Robert A. Seder, Timothy M. Caradonna, Katayoun Mansouri, Kedamawit Tilahun, Barton F. Haynes, Esther J. Lee, Erica Stover, Elizabeth Petzold, Mahnaz Minai, Tarra Von Holle, Kevin Wiehe, Longping V. Tse, David C. Montefiori, Thomas H. Oguin, Victoria Stalls, Robert J. Edwards, Kevin O. Saunders, Fangping Cai, Trevor Scobey, Blake M. Hauser, Mark G. Lewis, Gregory D. Sempowski, Tongqing Zhou, Andrew Foulger, Peter D. Kwong, Hanne Leth Andersen
Publikováno v:
bioRxiv
SummarySARS-CoV-2 neutralizing antibodies (NAbs) protect against COVID-19. A concern regarding SARS-CoV-2 antibodies is whether they mediate disease enhancement. Here, we isolated NAbs against the receptor-binding domain (RBD) and the N-terminal doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eecf5dfbdb9b3dd3dce1ff3a44ada9e3
https://doi.org/10.1101/2020.12.31.424729
https://doi.org/10.1101/2020.12.31.424729
Autor:
Hanne Leth Andersen, Hana Golding, Matthew Gagne, Robert J. Edwards, Kevin O. Saunders, Barton F. Haynes, Mihai L. Azoitei, Kartik Manne, Gregory D. Sempowski, Dapeng Li, Thomas N. Denny, Esther J. Lee, C. Todd DeMarco, Robert A. Seder, Elizabeth Petzold, Priyamvada Acharya, Surender Khurana, Mahnaz Minai, Mark G. Lewis, Trevor Scobey, R. Wes Rountree, Sophie M. C. Gobeil, Anyway B. Kapingidza, Thomas H. Oguin, Christopher W. Woods, Madison Berry, Rachel L. Spreng, Drew Weissman, Juanjie Tang, Mark A. Tomai, Christopher B. Fox, Ian N. Moore, Laura L. Sutherland, Kevin Wiehe, Ralph S. Baric, Robert Parks, Fangping Cai, Katayoun Mansouri, Norbert Pardi, Kevin W. Bock, Longping V. Tse, Daniel C. Douek, David R. Martinez, David C. Montefiori, Bianca M. Nagata, Aja Sanzone, Maggie Barr, S. Munir Alam, Haiyan Chen
Publikováno v:
Signal Transduction and Targeted Therapy
Nature
Nature
Betacoronaviruses caused the outbreaks of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome, as well as the current pandemic of SARS coronavirus 2 (SARS-CoV-2)1-4. Vaccines that elicit protective immunity against SARS-CoV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21d8feaf8225d5d115fd14e1099ae83
Autor:
Fangping Cai, Julia A. Jones, S. Munir Alam, Barton F. Haynes, Amanda Eaton, Nathan I. Nicely, Rachel K. Reed, William E. Walkowicz, Baptiste Aussedat, Esther Lee, David C. Montefiori, Brian E. Watts, Nelson R. Wu, Ashley M. Trama, Kevin O. Saunders
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 12, p e1008165 (2019)
PLoS Pathogens, Vol 15, Iss 12, p e1008165 (2019)
Viral glycoproteins are a primary target for host antibody responses. However, glycans on viral glycoproteins can hinder antibody recognition since they are self glycans derived from the host biosynthesis pathway. During natural HIV-1 infection, neut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bc5be53680f7d64c532815e1750fd9
http://europepmc.org/articles/PMC6936856
http://europepmc.org/articles/PMC6936856