Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Fanglin Gong"'
Autor:
Yue Xu, Shihao Ma, Haotian Cui, Jingan Chen, Shufen Xu, Fanglin Gong, Alex Golubovic, Muye Zhou, Kevin Chang Wang, Andrew Varley, Rick Xing Ze Lu, Bo Wang, Bowen Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Ionizable lipid nanoparticles (LNPs) are seeing widespread use in mRNA delivery, notably in SARS-CoV-2 mRNA vaccines. However, the expansion of mRNA therapies beyond COVID-19 is impeded by the absence of LNPs tailored for diverse cell types.
Externí odkaz:
https://doaj.org/article/0795b4f463354401be0387402f79d5c5
Autor:
Fanglin, Gong, Zibin, Wang, Rui, Mo, Yutong, Wang, Jin, Su, Xianglong, Li, Charos Tuychi Qizi, Omonova, Amari Mohamed, Khamis, Qing, Zhang, Mei, Dong, Zhigui, Su
Publikováno v:
Journal of Controlled Release. 349:940-953
Atherosclerotic cardiovascular diseases remain the leading causes of morbidity and mortality worldwide. Cholesterol crystals in atherosclerotic plaques play an essential role in atherosclerosis progression. However, no clinical drugs have been used f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61791234b7ff65dd818a470256113c1
https://doi.org/10.1016/j.jconrel.2022.07.021
https://doi.org/10.1016/j.jconrel.2022.07.021
Publikováno v:
Journal of Cardiovascular Pharmacology. 80:407-416
Cardiovascular disease is responsible for the largest number of deaths worldwide, and atherosclerosis is the primary cause. Apoptotic cell accumulation in atherosclerotic plaques leads to necrotic core formation and plaque rupture. Emerging findings
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521b9bde272c5ae2e244fbc1efd80c9e
https://doi.org/10.1097/fjc.0000000000001311
https://doi.org/10.1097/fjc.0000000000001311
Publikováno v:
Nano Letters. 21:9736-9745
Cholesterol crystals (CCs), originally accumulating in the lysosome of cholesterol-laden cells, can aggravate the progression of atherosclerosis. β-cyclodextrin (CD) is a potent cholesterol acceptor or CC solubilizer. However, the random extraction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65be40701723639d6bad26ab27a4fc4d
https://doi.org/10.1021/acs.nanolett.1c03664
https://doi.org/10.1021/acs.nanolett.1c03664