Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Fangjin Huang"'
Publikováno v:
BMC Medical Genetics, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background Mutations in the exonuclease domain of POLE, a DNA polymerase associated with DNA replication and repair, lead to cancers with ultra-high mutation rates. Most studies focus on intestinal and uterine cancers with POLE mutations. Th
Externí odkaz:
https://doaj.org/article/36df625431614427b58ba23563a7f0be
Autor:
Nathan Ing, Fangjin Huang, Andrew Conley, Sungyong You, Zhaoxuan Ma, Sergey Klimov, Chisato Ohe, Xiaopu Yuan, Mahul B. Amin, Robert Figlin, Arkadiusz Gertych, Beatrice S. Knudsen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Gene expression signatures are commonly used as predictive biomarkers, but do not capture structural features within the tissue architecture. Here we apply a 2-step machine learning framework for quantitative imaging of tumor vasculature to
Externí odkaz:
https://doaj.org/article/734bffa0c8884685a89d36929e58ac7d
Autor:
Zhaoxuan Ma, Stephen L. Shiao, Emi J. Yoshida, Steven Swartwood, Fangjin Huang, Michael E. Doche, Alice P. Chung, Beatrice S. Knudsen, Arkadiusz Gertych
Publikováno v:
Diagnostic Pathology, Vol 12, Iss 1, Pp 1-12 (2017)
Abstract Background Immune cell infiltrates (ICI) of tumors are scored by pathologists around tumor glands. To obtain a better understanding of the immune infiltrate, individual immune cell types, their activation states and location relative to tumo
Externí odkaz:
https://doaj.org/article/4af4bbb2c5624ba69e04560f997c26aa
Autor:
Matthew J Schiewer, Amy C Mandigo, Nicolas Gordon, Fangjin Huang, Sanchaika Gaur, Renée deLeeuw, Shuang G Zhao, Joseph Evans, Sumin Han, Theodore Parsons, Ruth Birbe, Peter McCue, Christopher McNair, Saswati N Chand, Ylenia Cendon‐Florez, Peter Gallagher, Jennifer J McCann, Neermala Poudel Neupane, Ayesha A Shafi, Emanuela Dylgjeri, Lucas J Brand, Tapio Visakorpi, Ganesh V Raj, Costas D Lallas, Edouard J Trabulsi, Leonard G Gomella, Adam P Dicker, Wm. Kevin Kelly, Benjamin E Leiby, Beatrice Knudsen, Felix Y Feng, Karen E Knudsen
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 12, Pp n/a-n/a (2018)
Abstract PARP‐1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of P
Externí odkaz:
https://doaj.org/article/044d966fd25b4793a1abaa4247be3583
Autor:
Joshua Saylor, Zhaoxuan Ma, Helen S. Goodridge, Fangjin Huang, Anne E. Cress, Stephen J. Pandol, Stephen L. Shiao, Adriana C. Vidal, Lily Wu, Nicholas G. Nickols, Arkadiusz Gertych, Beatrice S. Knudsen
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
An array of phenotypically diverse myeloid cells and macrophages (MC&M) resides in the tumor microenvironment, requiring multiplexed detection systems for visualization. Here we report an automated, multiplexed staining approach, named PLEXODY, that
Externí odkaz:
https://doaj.org/article/6580f48f4a8d4e54aa8d710fabc78fdc
Purpose: Tumors with mutations in the exonuclease domain of POLE are associated with ultrahigh mutation rates. POLE mutant tumors are best characterized in intestinal and uterine cancers and are associated with a prominent immune infiltrate and favor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edf656d7a70ad504b93f645f11a05726
https://doi.org/10.21203/rs.2.22445/v1
https://doi.org/10.21203/rs.2.22445/v1
Additional file 1: Supplementary Figure 1. Number of cases POLE mutations (n = 138) and mutations in the exomes of DNA polymerase genes in PANCAN. Supplementary Figure 2. Mutation counts for colorectal (CORE), stomach (STAD) and endometrial (UCEC) ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbab0af62bbcc5ed52677c32ceb47ba
Autor:
Anne E. Cress, Sungyong You, Beatrice S. Knudsen, Joshua M. Lang, Danislav S. Spassov, Kavita Shah, Michael R. Freeman, Sara Pollan, Jamie M. Sperger, Colm Morrissey, Fangjin Huang, Shakti Ranjan Satapathy, William G. Carter, Chia-Yi Chu, Neil A. Bhowmick, Mark M. Moasser
Publikováno v:
Oncogene. 37:2817-2836
Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed i
Autor:
Arkadiusz Gertych, Michael E. Doche, Steven Swartwood, Fangjin Huang, Alice P. Chung, Zhaoxuan Ma, Emi J. Yoshida, Beatrice S. Knudsen, Stephen L. Shiao
Publikováno v:
Diagnostic Pathology, Vol 12, Iss 1, Pp 1-12 (2017)
Diagnostic Pathology
Diagnostic Pathology
Background Immune cell infiltrates (ICI) of tumors are scored by pathologists around tumor glands. To obtain a better understanding of the immune infiltrate, individual immune cell types, their activation states and location relative to tumor cells n
Autor:
Eric N. Miller, Arash Amighi, Beatrice S. Knudsen, Michael T. Lewis, Arkadiusz Gertych, Fangjin Huang, Nathan Ing, Isla P. Garraway
Publikováno v:
Journal of Urology. 201
INTRODUCTION AND OBJECTIVES:Conventional histological analysis cannot differentiate diagnostic prostate needle biopsies (PNBX) from patients with localized disease (stage M0) versus those with de n...