Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Fangfei Qin"'
Autor:
Hui Wang, Boyuan Li, Linyu Zuo, Bo Wang, Yan Yan, Kai Tian, Rong Zhou, Chenlu Wang, Xizi Chen, Yongpeng Jiang, Haonan Zheng, Fangfei Qin, Bin Zhang, Yang Yu, Chao-Pei Liu, Yanhui Xu, Juntao Gao, Zhi Qi, Wulan Deng, Xiong Ji
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-26 (2022)
RNA polymerase II (Pol II) transcription factories play a central role in gene expression and 3D chromatin organization. Here, the authors demonstrate that RUVBL2 directly regulates Pol II clustering at active gene promoters.
Externí odkaz:
https://doaj.org/article/b2515b94263f46c690eb47a252390402
Autor:
Huixin Luo, Wei Tang, Hongyu Liu, Xiangmei Zeng, William Shu Ching Ngai, Rui Gao, Heyun Li, Ran Li, Huangtao Zheng, Jianting Guo, Fangfei Qin, Gang Wang, Kexin Li, Xinyuan Fan, Peng Zou, Peng R. Chen
Publikováno v:
Angewandte Chemie. 134
The dynamic interactions between RNAs and proteins play crucial roles in regulating diverse cellular processes. Proteome-wide characterization of these interactions in their native cellular context remains desirable but challenging. Herein, we develo
Autor:
Fangfei Qin, Boyuan Li, Hui Wang, Sihui Ma, Jiaofeng Li, Shanglin Liu, Linghao Kong, Huangtao Zheng, Rongfeng Zhu, Yu Han, Mingdong Yang, Kai Li, Xiong Ji, Peng R. Chen
Publikováno v:
Cell. 186:1066-1085.e36
Autor:
Haiping Song, Jianwei Lin, Xiao-Meng Li, Rongfeng Zhu, Gong Zhang, Fangfei Qin, Peng Chen, Xiucong Bao, Jingyi Zhao, Xiao Xie, Xiang David Li
Publikováno v:
Journal of the American Chemical Society. 139(19)
Posttranslational modifications (PTMs) of lysine are crucial histone marks that regulate diverse biological processes. The functional roles and regulation mechanism of many newly identified lysine PTMs, however, remain yet to be understood. Here we r
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4462-4466
A series of novel indanone derivatives was designed, synthesised and evaluated as potential agents for Alzheimer’s disease. Among them, compound 6a, with a piperidine group linked to indone by a two-carbon spacer, exhibited the most potent inhibito
Publikováno v:
Tetrahedron: Asymmetry. 23:333-338
The enantiopure multi-functional anti Alzheimer’s drug, Ladostigil (TV3326), was prepared by using asymmetric transfer hydrogenation (ATH) as a key step catalyzed by Ru–Cs-DPEN in an HCOONa–H 2 O–surfactant system. Good chemical yields with h
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(22)
Berberine derivatives with substituted amino groups linked at the 9-position using different carbon spacers were designed, synthesized, and biologically evaluated as inhibitors of acetylcholinesterase. Compound 10b, with a cyclohexylamino group linke