Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Fangdong Zou"'
Autor:
Caixia Wang, Rui Peng, Min Zeng, Zhenhua Zhang, Shengpeng Liu, Dan Jiang, Yuanyuan Lu, Fangdong Zou
Publikováno v:
Cell Death and Disease, Vol 11, Iss 12, Pp 1-14 (2020)
Abstract MircoRNA-21 (miR-21) was found to be highly expressed in various solid tumors, and its oncogenic properties have been extensively studied in recent years. However, the reason why miR-21 is highly expressed in various tumors remains elusive.
Externí odkaz:
https://doaj.org/article/7ba3319957fa44e2ba1518cd763dc29a
Publikováno v:
Cellular Physiology and Biochemistry, Vol 47, Iss 2, Pp 680-693 (2018)
Background/Aims: Mutations in the Ras/Raf/MEK/ERK pathway are detected in 50% of colorectal cancer cases and play a crucial role in cancer development and progression. Cobimetinib is a MEK inhibitor approved for the treatment of advanced melanoma and
Externí odkaz:
https://doaj.org/article/c7daa23ec0944d5f9e77f53b96339927
Publikováno v:
Cellular Physiology and Biochemistry, Vol 46, Iss 3, Pp 1065-1077 (2018)
Background/Aims: Giant pandas, an endangered species, are a powerful symbol of species conservation. Giant pandas may suffer from a variety of diseases. Owing to their highly specialized diet of bamboo, giant pandas are thought to have a relatively w
Externí odkaz:
https://doaj.org/article/cddc933312a8495b9f92c2be1168be8d
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158868 (2016)
Borneol is a compound widely used in ophthalmic preparations in China. Little is known about its exact role in treating eye diseases. Here we report that transient receptor potential melastatin 8 (TRPM8) channel is a pharmacological target of borneol
Externí odkaz:
https://doaj.org/article/09b30e6600694f57a83051cc6985ea30
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163893 (2016)
A basic goal in the development of recombinant proteins is the generation of cell lines that express the desired protein stably over many generations. Here, we constructed engineered Chinese hamster ovary cell lines (CHO-S) with a pCHO-hVR1 vector th
Externí odkaz:
https://doaj.org/article/e9cd4fb6bd314ef1beadeaafbabc63b2
Supplementary Table S1 shows 17-AAG IC50 in 6 CRC cell lines with different KRAS, BRAF, PIK3CA, p53 and FBW7 genotypes. Supplementary Fig. S1 shows induction of proapoptotic Bcl-2 family proteins by 17-AAG in FBW7-mutant colon cancer cells. Supplemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53557f1472e07afe361c2ef300c22564
https://doi.org/10.1158/1535-7163.22508086.v1
https://doi.org/10.1158/1535-7163.22508086.v1
Autor:
Xudong Zhao, Fangdong Zou, Shu Zhang, Antonio Iavarone, Anna Lasorella, Hua Jiang, Sanqi An, Lei Li, Lanzhen Yan, Xiaoping Yu, Daomei Cheng, Xiaohong Zhang, Bin Sun, Dong Yang
Supplementary Table S2 List of antibodies used in this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856f5c04d52ba2f3400a5b80666c8ae4
https://doi.org/10.1158/0008-5472.22415895
https://doi.org/10.1158/0008-5472.22415895
Autor:
Lin Zhang, Jian Yu, Fangdong Zou, Zaneta Nikolovska-Coleska, Dongshi Chen, Shuai Tan, Peng Wang, Jingshan Tong
Table S1. Sequences of PCR primers used for vector construction and PCR screening of Mcl-1-KI cell lines, and for analysis of Mcl-1 mRNA expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d316ff3192460647ff253cdafb7e2af
https://doi.org/10.1158/0008-5472.22416713.v1
https://doi.org/10.1158/0008-5472.22416713.v1
Autor:
Lin Zhang, Jian Yu, Fangdong Zou, Zaneta Nikolovska-Coleska, Dongshi Chen, Shuai Tan, Peng Wang, Jingshan Tong
Figure S1. Regorafenib and sorafenib did not affect Mcl-1 mRNA expression but induced GSK3β-dependent Mcl-1 degradation. A transfected quadruple mutant in 4 putative phosphorylation sites (S121A/E125A/S159A/T163A) of Mcl-1 was resistant to regorafen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f84a670cf35a632c736cd4ed52f5ae8
https://doi.org/10.1158/0008-5472.22416716.v1
https://doi.org/10.1158/0008-5472.22416716.v1
Autor:
Lin Zhang, Jian Yu, Fangdong Zou, Zaneta Nikolovska-Coleska, Dongshi Chen, Shuai Tan, Peng Wang, Jingshan Tong
The Bcl-2 family protein Mcl-1 is often degraded in cancer cells subjected to effective therapeutic treatment, and defective Mcl-1 degradation has been associated with intrinsic and acquired drug resistance. However, a causal relationship between Mcl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14a0650b6dd1528ae2d2a5f95a71b49d
https://doi.org/10.1158/0008-5472.c.6509627.v1
https://doi.org/10.1158/0008-5472.c.6509627.v1