Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Fang-Chun Kung"'
Autor:
Fang-Chun Kung, 龔芳醇
102
An effective 1,3-dipolar cycloaddition was successfully developed for synthesis 5-amino-1,2,4-triazoles by reacting hydrazonoyl hydrochlorides (nitrilimines) with carbodiimides in the presence of triethylamine as a base catalyst. Carbodiimid
An effective 1,3-dipolar cycloaddition was successfully developed for synthesis 5-amino-1,2,4-triazoles by reacting hydrazonoyl hydrochlorides (nitrilimines) with carbodiimides in the presence of triethylamine as a base catalyst. Carbodiimid
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/yu5n4s
Autor:
Su-Ying Wu, Tsu Hsu, Weir-Torn Jiaang, Ching-Cheng Hsueh, Hsin-Huei Chang, Fang-Chun Kung, Cheng-Tai Lu, Yi-Hui Peng, Ching-Chuan Kuo, Lung-Chun Lee, Chih-Hsiang Huang
Publikováno v:
Journal of Medicinal Chemistry
Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) plays an important role in one-carbon metabolism. The MTHFD2 gene is upregulated in various cancers but very low or undetectable in normal proliferating cells, and therefore a potential target for ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefd173f9bbcc3bc6e5f8b46d32a1935
https://doi.org/10.1021/acs.jmedchem.1c00663
https://doi.org/10.1021/acs.jmedchem.1c00663
Autor:
Hui-You Lin, Yi-Hui Peng, Kuo Wei Huang, Chen-Lung Huang, Mine-Hsine Wu, Chuan Shih, Teng-Kuang Yeh, Weir-Torn Jiaang, Ching-Chuan Kuo, Tsu Hsu, Ching-Ping Chen, Ya-Ling Weng, Chiung-Tong Chen, Fang-Chun Kung, Wen-Hsing Lin, Hui Yi Shiao, Jen-Shin Song, Ling-Hui Chou, Tsung-Sheng Wu, Kuei-Jung Yen, Pei-Chen Wang, Ching-Cheng Hsueh, Yu-Chieh Su, Cheng-Tai Lu, Hui-Jen Tsai, Su-Ying Wu, Li-Tzong Chen, Po-Chu Kuo
Publikováno v:
Journal of Medicinal Chemistry. 62:11135-11150
Gastrointestinal stromal tumors (GISTs) are prototypes of stem cell factor receptor (c-KIT)-driven cancer. Two receptor tyrosine kinases, c-KIT and fms-tyrosine kinase (FLT3), are frequently mutated in acute myeloid leukemia (AML) patients, and these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60499fc4136ddd2d5cf080a65b7dda3b
https://doi.org/10.1021/acs.jmedchem.9b01229
https://doi.org/10.1021/acs.jmedchem.9b01229
Autor:
Tsu Hsu, Yi-Hui Peng, Yu-Chieh Su, Weir-Torn Jiaang, Jia-Yu Chang, Hui-You Lin, Teng-Kuang Yeh, Cheng-Tai Lu, Tsung-Sheng Wu, Hui Yi Shiao, Chiung-Tong Chen, Jen-Shin Song, Wen-Hsing Lin, Pei-Chen Wang, Su-Ying Wu, Li-Tzong Chen, Ching-Cheng Hsueh, Fang-Chun Kung, Hui-Jen Tsai, Lung-Chun Lee, Chih-Hsiang Tu
Publikováno v:
Journal of Medicinal Chemistry. 62:3940-3957
Drug resistance due to acquired mutations that constitutively activate c-KIT is a significant challenge in the treatment of patients with gastrointestinal stromal tumors (GISTs). Herein, we identified 1-(5-ethyl-isoxazol-3-yl)-3-(4-{2-[6-(4-ethylpipe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01c2cdf54c196cc57b9d74b4e146ba3
https://doi.org/10.1021/acs.jmedchem.8b01845
https://doi.org/10.1021/acs.jmedchem.8b01845
Autor:
Ming-Yen Hsieh, Weir-Torn Jiaang, Chiung-Tong Chen, Cheng-Tai Lu, Fang-Chun Kung, Teng-Kuang Yeh, Zheng-Sheng Lai, Tsu Hsu, Chun-Hung Lin, Che Kun James Shen, Yu Chi Chou
Publikováno v:
European Journal of Medicinal Chemistry. 209:112938
Reactivation of fetal hemoglobin (HbF) expression by therapeutic agents has been suggested as an alternative treatment to modulate anemia and the related symptoms of severe β-thalassemia and sickle cell disease (SCD). Hydroxyurea (HU) is the first U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961e9616f0107d6556ca70741f219b28
https://doi.org/10.1016/j.ejmech.2020.112938
https://doi.org/10.1016/j.ejmech.2020.112938