Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Fang I. Huang"'
Autor:
Fang-I Huang, Yi-Wen Wu, Ting-Yi Sung, Jing-Ping Liou, Mei-Hsiang Lin, Shiow-Lin Pan, Chia-Ron Yang
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
In multiple myeloma (MM), homeostasis is largely maintained by misfolded protein clearance via the proteasomal and aggresomal pathways. Histone deacetylase 6 (HDAC6) binds polyubiquitinated proteins and dynein motors and transports this protein cargo
Externí odkaz:
https://doaj.org/article/45e04ed29b93454fb3b01cb9d5a3a7a1
Publikováno v:
Journal of the Formosan Medical Association, Vol 113, Iss 12, Pp 934-939 (2014)
Lymphoid-enhancing factor 1 (LEF1) is a transcription factor mediating Wnt/β-catenin signaling. In this study, we analyzed the clinicopathologic significance of LEF1 expression in oral squamous cell carcinoma (OSCC). Methods: Expression levels of LE
Externí odkaz:
https://doaj.org/article/afef7b4ecb304ce3b012938b67caa032
Autor:
Kunal Nepali, Fang I. Huang, Mei Jung Lai, Hsueh Yun Lee, Chia-Ron Yang, Jing Ping Liou, Chih Yi Chang, Yu Hsuan Li, Hsiang Ling Huang
Publikováno v:
Journal of Medicinal Chemistry. 61:905-917
A series of bicyclic arylamino/heteroarylamino hydroxamic acids (7–31) have been examined as novel histone deacetylase 6 (HDAC6) inhibitors. One compound (13) exhibits remarkable inhibitory activity of HDAC6 with an IC50 value of 0.29 nM, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca94d617bd0fcfde4cc72483db5cd5d9
https://doi.org/10.1021/acs.jmedchem.7b01404
https://doi.org/10.1021/acs.jmedchem.7b01404
Publikováno v:
Journal of natural products. 82(7)
Alzheimer's disease (AD) is a neurodegenerative disease and a common cause of dementia, manifesting as progressive memory loss and cognitive decline. Moscatilin, which reportedly reduces fever and is anti-inflammatory, is the bibenzyl extract from De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccd847483babfec2124929934366027
https://pubmed.ncbi.nlm.nih.gov/31291099
https://pubmed.ncbi.nlm.nih.gov/31291099
Autor:
Jing Ping Liou, Sheng Jun Fan, Kai Cheng Hsu, Tony Eight Lin, Yu Hsuan Li, Hsin Yi Chao, Chia-Ron Yang, Mei Jung Lai, Hsueh Yun Lee, Teng Kuang Yeh, Hsiang Ling Huang, Fang I. Huang
Publikováno v:
Journal of medicinal chemistry. 61(16)
This paper reports the development of a series of 5-aroylindolyl-substituted hydroxamic acids. N-Hydroxy-4-((5-(4-methoxybenzoyl)-1 H-indol-1-yl)methyl)benzamide (6) has potent inhibitory selectivity against histone deacetylase 6 (HDAC6) with an IC50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ef41b2c12b4883b20de1f5989875f1
https://pubmed.ncbi.nlm.nih.gov/30028616
https://pubmed.ncbi.nlm.nih.gov/30028616
Publikováno v:
Cell Death and Disease, Vol 9, Iss 6, Pp 1-14 (2018)
Cell Death & Disease
Cell Death & Disease
Alzheimer’s disease (AD) is a dreadful neurodegenerative disease that leads to severe impairment of cognitive function, leading to a drastic decline in the quality of life. The primary pathological features of AD include senile plaques (SPs) and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851b8b5344169b895ab8869cd3fc1469
https://doi.org/10.1038/s41419-018-0688-5
https://doi.org/10.1038/s41419-018-0688-5
Autor:
Samir Mehndiratta, Fang I. Huang, Ssu Chia Lai, Yen Chia Huang, Jing Ping Liou, Chia-Ron Yang
Publikováno v:
Oncotarget
// Yen-Chia Huang 1, * , Fang-I Huang 1, * , Samir Mehndiratta 2 , Ssu-Chia Lai 1 , Jing-Ping Liou 2 , Chia-Ron Yang 1 1 School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan 2 School of Pharmacy, College of Pharmacy, Ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf996c8df9f53eb04cb2b5ac0c0367d
https://doi.org/10.18632/oncotarget.4068
https://doi.org/10.18632/oncotarget.4068
Publikováno v:
Journal of the Formosan Medical Association, Vol 113, Iss 12, Pp 934-939 (2014)
Background/Purpose Lymphoid-enhancing factor 1 (LEF1) is a transcription factor mediating Wnt/β-catenin signaling. In this study, we analyzed the clinicopathologic significance of LEF1 expression in oral squamous cell carcinoma (OSCC). Methods Expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0115a65442d3f8447c2481f435ad69b6
http://www.sciencedirect.com/science/article/pii/S092966461300257X
http://www.sciencedirect.com/science/article/pii/S092966461300257X
Autor:
Hsueh-Yun Lee, Kunal Nepali, Fang-I. Huang, Chih-Yi Chang, Mei-Jung Lai, Yu-Hsuan Li, Hsiang-Ling Huang, Chia-Ron Yang, Jing-Ping Liou
Publikováno v:
Journal of Medicinal Chemistry; 2/8/2018, Vol. 61 Issue 3, p905-917, 13p
Publikováno v:
Carcinogenesis. 33(6)
Hepatocyte growth factor (HGF) is a secretory protein that plays important roles in cancer growth and metastasis. Lymphoid-enhancing factor 1 (LEF1) is a transcription factor mediating Wnt/β-catenin signaling. Using microarray analysis, we found HGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a4708ccbb879b0bba514d7be4d3169
https://pubmed.ncbi.nlm.nih.gov/22436613
https://pubmed.ncbi.nlm.nih.gov/22436613