Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[d]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD).

Autor: Zeng, Ruoqing, Fang, Meimiao, Shen, Ancheng, Chai, Xiaolei, Zhao, Yumiao, Liu, Mingyao, Zhu, Lingfeng, Rui, Weiwei, Feng, Bo, Hong, Liang, Ding, Chunyong, Song, Zilan, Lu, Weiqiang, Zhang, Ao

Publikováno v: Journal of Medicinal Chemistry; 3/14/2024, Vol. 67 Issue 5, p3520-3541, 22p

Discovery of Pyridinone Derivatives as Potent, Selective, and Orally Bioavailable Adenosine A2A Receptor Antagonists for Cancer Immunotherapy.

Autor: Zhu, Chenyu, Ze, Shuyin, Zhou, Ronghui, Yang, Xinyu, Wang, Haojie, Chai, Xiaolei, Fang, Meimiao, Liu, Mingyao, Wang, Yonghui, Lu, Weiqiang, Xie, Qiong

Publikováno v: Journal of Medicinal Chemistry; 4/13/2023, Vol. 66 Issue 7, p4734-4754, 21p

Discovery of Pyridinone Derivatives as Potent, Selective, and Orally Bioavailable Adenosine A2AReceptor Antagonists for Cancer Immunotherapy

Autor: Zhu, Chenyu, Ze, Shuyin, Zhou, Ronghui, Yang, Xinyu, Wang, Haojie, Chai, Xiaolei, Fang, Meimiao, Liu, Mingyao, Wang, Yonghui, Lu, Weiqiang, Xie, Qiong

Publikováno v: Journal of Medicinal Chemistry; April 2023, Vol. 66 Issue: 7 p4734-4754, 21p

Ubiquitination of IGF2BP3 by E3 ligase MKRN2 regulates the proliferation and migration of human neuroblastoma SHSY5Y cells

Autor: Jia, Caiwei, Tang, Hongli, Yang, Yun, Yuan, Shilin, Han, Tianting, Fang, Meimiao, Huang, Shuting, Hu, Ronggui, Li, Chuanyin, Geng, Wujun

Publikováno v: In Biochemical and Biophysical Research Communications 13 August 2020 529(1):43-50

Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[ d ]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD).

Autor: Zeng R; Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.; National Key Laboratory of Innovative Immunotherapy, Shanghai 200240, China., Fang M; Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China., Shen A; Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.; Lingang Laboratory, Shanghai 200210, China.; National Key Laboratory of Innovative Immunotherapy, Shanghai 200240, China., Chai X; Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China., Zhao Y; Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China., Liu M; Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China., Zhu L; Chemical Biology Research Center at School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China., Rui W; Department of General Surgery and Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China., Feng B; Department of General Surgery and Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China., Hong L; Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.; National Key Laboratory of Innovative Immunotherapy, Shanghai 200240, China., Ding C; Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.; National Key Laboratory of Innovative Immunotherapy, Shanghai 200240, China., Song Z; Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.; National Key Laboratory of Innovative Immunotherapy, Shanghai 200240, China., Lu W; Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China., Zhang A; Shanghai Frontiers Science Center for Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.; Lingang Laboratory, Shanghai 200210, China.; National Key Laboratory of Innovative Immunotherapy, Shanghai 200240, China.; Chemical Biology Research Center at School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 3520-3541. Date of Electronic Publication: 2024 Feb 28.