A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program.

Autor: Rice S; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Jackson T; Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK., Crump NT; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Fordham N; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Elliott N; Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK., O'Byrne S; Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK., Fanego MDML; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Addy D; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Crabb T; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Dryden C; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Inglott S; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Ladon D; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Wright G; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Bartram J; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Ancliff P; Department of Haematology, Great Ormond Street Hospital for Children, London, UK., Mead AJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Halsey C; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.; Department of Paediatric Haematology, Royal Hospital for Children, Glasgow, UK., Roberts I; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK., Milne TA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. thomas.milne@imm.ox.ac.uk., Roy A; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. anindita.roy@paediatrics.ox.ac.uk.; Department of Paediatrics and NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK. anindita.roy@paediatrics.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2021 Nov 25; Vol. 12 (1), pp. 6905. Date of Electronic Publication: 2021 Nov 25.