Apilimod dimesylate in C9orf72 amyotrophic lateral sclerosis: a randomized phase 2a clinical trial.

Autor: Babu S; Sean M Healey & AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Nicholson KA; Sean M Healey & AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Sanofi, Cambridge, MA 02139, USA., Rothstein JD; Department of Neurology, Brain Science Institute, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Swenson A; Department of Neurology, University of Iowa, Iowa city, IA 52242, USA., Sampognaro PJ; Neuromuscular Division, Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA., Pant P; Sean M Healey & AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Macklin EA; Biostatistics Center at Massachusetts General Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Spruill S; Applied Statistics and Consulting, Spruce Pine, NC 28777, USA., Paganoni S; Sean M Healey & AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Gendron TF; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Prudencio M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Petrucelli L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA., Nix D; Certara, Princeton, NJ 08540, USA., Landrette S; OrphAI Therapeutics, Guilford, CT 06437, USA., Nkrumah E; OrphAI Therapeutics, Guilford, CT 06437, USA., Fandrick K; OrphAI Therapeutics, Guilford, CT 06437, USA., Edwards J; OrphAI Therapeutics, Guilford, CT 06437, USA., Young PR; OrphAI Therapeutics, Guilford, CT 06437, USA.

Publikováno v: Brain : a journal of neurology [Brain] 2024 Sep 03; Vol. 147 (9), pp. 2998-3008.

Menthol Pretreatment Alleviates Campylobacter jejuni -Induced Enterocolitis in Human Gut Microbiota-Associated IL-10 −/− Mice.

Autor: Heimesaat, Markus M.¹ (AUTHOR) markus.heimesaat@charite.de, Langfeld, Luis Q.¹ (AUTHOR), Schabbel, Niklas¹ (AUTHOR), Shayya, Nizar W.¹ (AUTHOR), Mousavi, Soraya¹ (AUTHOR), Bereswill, Stefan¹ (AUTHOR)

Publikováno v: Biomolecules (2218-273X). Mar2024, Vol. 14 Issue 3, p290. 15p.

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Three-dimensional structure of cyclic antibiotic teicoplanin aglycone using NMR distance and dihedral angle restraints in a DMSO solvation model.

Autor: Gonnella NC; Materials and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA., Grinberg N; Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA., Mcloughlin M; Materials and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA., Choudhary O; Materials and Analytical Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA.; Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA., Fandrick K; Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA., Ma S; Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA.

Publikováno v: Magnetic resonance in chemistry : MRC [Magn Reson Chem] 2015 Oct; Vol. 53 (10), pp. 829-35. Date of Electronic Publication: 2015 Jul 01.

Catalyst‐Free Propargylboration of Ketones with Allenyl‐Bpins: Highly Stereoselective Synthesis of tert‐Homopropargyl Alcohols Bearing Vicinal Stereocenters.

Autor: Zhang, Qian‐Cheng¹ (AUTHOR), Zhong, Qin¹ (AUTHOR) zq304@njust.edu.cn, Zhao, Jian¹ (AUTHOR) jzhao@njust.edu.cn

Publikováno v: Chemistry - A European Journal. Dec2023, Vol. 29 Issue 67, p1-5. 5p.