Evaluation of Pharmacokinetic Drug Interactions of the Direct-Acting Antiviral Agents Elbasvir and Grazoprevir with Pitavastatin, Rosuvastatin, Pravastatin, and Atorvastatin in Healthy Adults.

Autor: Caro L; Merck & Co., Inc., Kenilworth, NJ, USA. Luzelena_caro@merck.com.; Merck & Co., Inc., 770 Sumneytown Pike, WP75B-110, West Point, PA, 19486, USA. Luzelena_caro@merck.com., Prueksaritanont T; Merck & Co., Inc., Kenilworth, NJ, USA.; Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand., Fandozzi CM; Merck & Co., Inc., Kenilworth, NJ, USA., Feng HP; Merck & Co., Inc., Kenilworth, NJ, USA., Guo Z; Merck & Co., Inc., Kenilworth, NJ, USA., Wolford D; Merck & Co., Inc., Kenilworth, NJ, USA., Panebianco D; Merck & Co., Inc., Kenilworth, NJ, USA., Fraser IP; Merck & Co., Inc., Kenilworth, NJ, USA.; Abide Therapeutics, San Diego, CA, USA., Levine V; Merck & Co., Inc., Kenilworth, NJ, USA., Swearingen D; Celerion Inc., Tempe, AZ, USA., Butterton JR; Merck & Co., Inc., Kenilworth, NJ, USA., Iwamoto M; Merck & Co., Inc., Kenilworth, NJ, USA., Yeh WW; Merck & Co., Inc., Kenilworth, NJ, USA.

Publikováno v: Clinical drug investigation [Clin Drug Investig] 2021 Feb; Vol. 41 (2), pp. 133-147.

P2-quinazolinones and bis-macrocycles as new templates for next-generation hepatitis C virus NS3/4a protease inhibitors: discovery of MK-2748 and MK-6325.

Autor: Rudd MT; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA (USA). michael_rudd@merck.com., Butcher JW, Nguyen KT, McIntyre CJ, Romano JJ, Gilbert KF, Bush KJ, Liverton NJ, Holloway MK, Harper S, Ferrara M, DiFilippo M, Summa V, Swestock J, Fritzen J, Carroll SS, Burlein C, DiMuzio JM, Gates A, Graham DJ, Huang Q, McClain S, McHale C, Stahlhut MW, Black S, Chase R, Soriano A, Fandozzi CM, Taylor A, Trainor N, Olsen DB, Coleman PJ, Ludmerer SW, McCauley JA

Publikováno v: ChemMedChem [ChemMedChem] 2015 Apr; Vol. 10 (4), pp. 727-35. Date of Electronic Publication: 2015 Mar 10.

Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor.

Autor: Harper S; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., McCauley JA; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Rudd MT; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Ferrara M; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., DiFilippo M; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Crescenzi B; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Koch U; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Petrocchi A; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Holloway MK; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Butcher JW; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Romano JJ; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Bush KJ; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Gilbert KF; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., McIntyre CJ; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Nguyen KT; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Nizi E; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Carroll SS; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Ludmerer SW; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Burlein C; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., DiMuzio JM; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Graham DJ; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., McHale CM; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Stahlhut MW; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Olsen DB; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Monteagudo E; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Cianetti S; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Giuliano C; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Pucci V; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Trainor N; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Fandozzi CM; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Rowley M; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Coleman PJ; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Vacca JP; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States., Summa V; Departments of Medicinal Chemistry, Drug Metabolism, and Molecular Modeling, IRBM, Merck Research Laboratories , Rome, Italy., Liverton NJ; Departments of Medicinal Chemistry, Antiviral Research, Drug Metabolism, and Chemistry, Modeling and Informatics, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2012 Mar 02; Vol. 3 (4), pp. 332-6. Date of Electronic Publication: 2012 Mar 02 (Print Publication: 2012).

Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor.

Autor: McCauley JA; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA. john_mccauley@merck.com, McIntyre CJ, Rudd MT, Nguyen KT, Romano JJ, Butcher JW, Gilbert KF, Bush KJ, Holloway MK, Swestock J, Wan BL, Carroll SS, DiMuzio JM, Graham DJ, Ludmerer SW, Mao SS, Stahlhut MW, Fandozzi CM, Trainor N, Olsen DB, Vacca JP, Liverton NJ

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2010 Mar 25; Vol. 53 (6), pp. 2443-63.