Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Fancher, Sean"'
Truss structures at macro-scale are common in a number of engineering applications and are now being increasingly used at the micro-scale to construct metamaterials. In analyzing the properties of a given truss structure, it is often necessary to und
Externí odkaz:
http://arxiv.org/abs/2309.02448
Existing models of adaptation in biological flow networks consider their constituent vessels (e.g. veins and arteries) to be rigid, thus predicting a non physiological response when the drive (e.g. the heart) is dynamic. Here we show that incorporati
Externí odkaz:
http://arxiv.org/abs/2210.06557
Autor:
Fancher, Sean, Katifori, Eleni
The dynamics of flow within a material transport network is dependent upon the dynamics of its power source. Responding to a change of these dynamics is critical for the fitness of living flow networks, e.g. the animal vasculature, which are subject
Externí odkaz:
http://arxiv.org/abs/2109.13829
Autor:
Fancher, Sean, Katifori, Eleni
Transport networks are typically optimized, either by evolutionary pressures in biological systems or by human design in engineered structures. In the case of systems such as the animal vasculature, the transport of fluids is hindered by the inherent
Externí odkaz:
http://arxiv.org/abs/2102.13197
Publikováno v:
Phys. Rev. Lett. 124, 168101 (2020)
Metastatic cancer cells detect the direction of lymphatic flow by self-communication: they secrete and detect a chemical which, due to the flow, returns to the cell surface anisotropically. The secretion rate is low, meaning detection noise may play
Externí odkaz:
http://arxiv.org/abs/1912.05091
Publikováno v:
Phys. Rev. E 101, 062420 (2020)
Cellular behaviors such as migration, division, and differentiation rely on precise timing, and yet the molecular events that govern these behaviors are highly stochastic. We investigate regulatory strategies that decrease the timing noise of molecul
Externí odkaz:
http://arxiv.org/abs/1910.05413
Autor:
Fancher, Sean, Mugler, Andrew
Morphogen profiles allow cells to determine their position within a developing organism, but the mechanisms behind the formation of these profiles are still not well agreed upon. Here we derive fundamental limits to the precision of morphogen concent
Externí odkaz:
http://arxiv.org/abs/1806.08318
Publikováno v:
Phys. Rev. Lett. 119, 188101 (2017)
Multicellular chemotaxis can occur via individually chemotaxing cells that are mechanically coupled. Alternatively, it can emerge collectively, from cells chemotaxing differently in a group than they would individually. Here we consider collective mo
Externí odkaz:
http://arxiv.org/abs/1703.09666
Autor:
Fancher, Sean, Mugler, Andrew
Publikováno v:
Phys. Rev. Lett. 118, 078101 (2017)
The precision of concentration sensing is improved when cells communicate. Here we derive the physical limits to concentration sensing for cells that communicate over short distances by directly exchanging small molecules (juxtacrine signaling), or o
Externí odkaz:
http://arxiv.org/abs/1603.04108
Gradient sensing underlies important biological processes including morphogenesis, polarization, and cell migration. The precision of gradient sensing increases with the length of a detector (a cell or group of cells) in the gradient direction, since
Externí odkaz:
http://arxiv.org/abs/1512.08328