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Akademický článek

Development of a novel disulfidptosis-correlated m6A/m1A/m5C/m7G gene signature to predict prognosis and therapeutic response for lung adenocarcinoma patients by integrated machine-learning

Autor: Bilin Xu, Liangyu Zhang, Lijie Lin, Yanfeng Lin, Fancai Lai

Publikováno v: Discover Oncology, Vol 15, Iss 1, Pp 1-22 (2024)

Abstract Background Lung adenocarcinoma (LUAD) represents a significant global health burden, necessitating advanced prognostic tools for improved patient management. RNA modifications (m6A, m1A, m5C, m7G), and disulfidptosis, a novel cell death mech

Externí odkaz: https://doaj.org/article/bc02203f24384a31bc5e5e96417a17c3

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Akademický článek

Machine-learning developed an iron, copper, and sulfur-metabolism associated signature predicts lung adenocarcinoma prognosis and therapy response

Autor: Liangyu Zhang, Xun Zhang, Maohao Guan, Jianshen Zeng, Fengqiang Yu, Fancai Lai

Publikováno v: Respiratory Research, Vol 25, Iss 1, Pp 1-26 (2024)

Abstract Background Previous studies have largely neglected the role of sulfur metabolism in LUAD, and no study has combine iron, copper, and sulfur-metabolism associated genes together to create prognostic signatures. Methods This study encompasses

Externí odkaz: https://doaj.org/article/5e85773028a7403bb84c4d29c52898e3

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Akademický článek

Longitudinal analysis of quality of life in primary lung cancer patients with chlamydia pneumoniae infection: a time-to-deterioration model

Autor: Zishan Chen, Jinman Zhuang, Maolin Liu, Xinying Xu, Yuhang Liu, Shuyan Yang, Jinbao Xie, Nanlong Lin, Fancai Lai, Fei He

Publikováno v: BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-12 (2024)

Abstract Background Chlamydia pneumoniae (Cpn) IgG and IgA has been strongly linked to lung cancer, but its impact on patients' quality of life remains unclear. Our objective was to investigate the relationship between pre-treatment Cpn IgG and IgA a

Externí odkaz: https://doaj.org/article/c0149ecbebe04fd486d696112a049183

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Akademický článek

In-depth single-cell and bulk-RNA sequencing developed a NETosis-related gene signature affects non-small-cell lung cancer prognosis and tumor microenvironment: results from over 3,000 patients

Autor: Liangyu Zhang, Xun Zhang, Maohao Guan, Fengqiang Yu, Fancai Lai

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

BackgroundCell death caused by neutrophil extracellular traps (NETs) is known as NETosis. Despite the increasing importance of NETosis in cancer diagnosis and treatment, its role in Non-Small-Cell Lung Cancer (NSCLC) remains unclear.MethodsA total of

Externí odkaz: https://doaj.org/article/3ccedd3c553b46268d49bc8dd97fdad4

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Akademický článek

Transareolar uniportal thoracoscopic extended thymectomy for patients with myasthenia gravis

Autor: Jianbo Lin, Nanlong Lin, Xu Li, Fancai Lai

Publikováno v: Frontiers in Surgery, Vol 9 (2022)

BackgroundTransareolar uniportal thoracoscopic extended thymectomy (TUTET) has not been previously reported. We attempted to assess the feasibility and safety of TUTET for male myasthenia gravis (MG) patients.Patients and methodsFrom February 2013 to

Externí odkaz: https://doaj.org/article/0fa82a13413b4a0183706452c968cda3

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Akademický článek

Autor: Jinman Zhuang, Maohao Guan, Maolin Liu, Yuhang Liu, Shuyan Yang, Zhijian Hu, Fancai Lai, Fei He

Publikováno v: Frontiers in Genetics, Vol 12 (2021)

Background: Approximately 50% of thymoma patients also show myasthenia gravis (MG), which is an autoimmune disease; however, the pathogenesis of MG-associated thymoma remains elusive. Our aim was to investigate immune-related lncRNA profiles of a set

Externí odkaz: https://doaj.org/article/76481d481b1c4104a129173055897716

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Knockdown of deoxythymidylate kinase suppresses progression and epithelial-mesenchymal-transition of lung adenocarcinoma via STAT3 signaling

Autor: Fengqiang Yu, Yanxun Chen, Ruiqin Qiu, Nanlong Lin, Yinhe Yin, Yi Zhuo, Jianbo Lin, Fancai Lai

Publikováno v: Physiological Genomics. 55:213-221

DTYMK plays an important role in progression of LUAD through the STAT3 signaling pathway. YMU1 may serve as a novel drug to suppress the development of LUAD.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0206c4306e6f707ad68693fba6adca5
https://doi.org/10.1152/physiolgenomics.00001.2023

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Comprehensively analysis of the FGD family with potential effects on prognosis and immune infiltration in lung adenocarcinoma

Autor: Liangyu Zhang, Fengqiang Yu, Maohao Guan, Xuan Huang, Nanlong Lin, Fei He, Fancai Lai

Background：The FGD family consists of six genes, namely FGD1/2/3/4/5/6. Their roles in lung adenocarcinoma have been unidentified. This research focused on determining the diagnostic efficacy, prognostic value, and immune-related functions of them

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35e671ce9569aa8302abf38470712f49
https://doi.org/10.21203/rs.3.rs-2529550/v1

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Protein Tyrosine Phosphatase Receptor Type R (PTPRR) Reduces AChR Clustering by Dephosphorylating MuSK

Autor: Yanxun Chen, Maohao Guan, Fengqiang Yu, Zhongshan Yang, Weiqiang Yi, Xuan Huang, Ruiqin Qiu, Fancai Lai

Publikováno v: Disease markers. 2022

Neuromuscular junction (NMJ) formation and maintenance depend on the proper localization and concentration of various molecules at synaptic contact sites. Acetylcholine receptor (AChR) clustering on the postsynaptic membrane is a cardinal event in NM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd83b9796f65b1a2f7c781fdc346772f
https://pubmed.ncbi.nlm.nih.gov/36105254

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