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Self-assembly of antifungal agent 5-fluorocytosine and nutrient trans-p-coumaric acid furnishes a cocrystal with the potential to reduce toxicity and side effects for the drug: a case study combining theory with experiment

Autor: Fan-Zhi Bu, Yue-Ming Yu, Yu Yu, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li

Publikováno v: New Journal of Chemistry. 47:1328-1341

Cocrystallization of 5-fluorocytosine (FLCY) and trans-p-coumaric acid was first reported. Systematic studies combining theory with experiment revealed that both solubility and dissolution rate of FLCY can be down-regulated via cocrystallization.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6c2a52f823d318835003fdef02c799a
https://doi.org/10.1039/d2nj03622c

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Salification-driven strategy toward the hydrophobic molecular salt of the antifungal drug 5-fluorocytosine and protocatechuic acid with triple-helix structure offers an innovative insight for conquering adverse drug reactions

Autor: Fan-Zhi Bu, Yue-Ming Yu, Lin-Lin Zhang, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li

Publikováno v: CrystEngComm. 25:1951-1964

The hydrophobic molecular salt of 5-fluorocytosine (FYT) with protocatechuic acid (PCA) was first reported, and its dissolution behaviors were systematically studied by combining theory with experiment.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe0bfa6034005f00ebd025bebe624fb7
https://doi.org/10.1039/d2ce01523d

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5-fluorouracil-caffeic acid cocrystal delivery agent with long-term and synergistic high-performance antitumor effects

Autor: Yue-Ming Yu, Fan-Zhi Bu, Yu Yu, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li

Publikováno v: Nanomedicine. 17:2215-2229

Aim: To explore how to transform cocrystals of the anticancer drug 5-fluorouracil (FL) with caffeic acid (CF; FL-CF-2H2O) into a nanoformulation, a self-assembly strategy of cocrystal-loaded micelles is proposed. Methods: Nanomicelles were assembled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f0321ab83c8a4b7ae62b7479a0c8702
https://doi.org/10.2217/nnm-2022-0208

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Cocrystallization-driven self-assembly with vanillic acid offers a new opportunity for surmounting fast and excessive absorption issues of antifungal drug 5-fluorocytosine: a combined theoretical and experimental research

Autor: Fan-Zhi Bu, Yue-Ming Yu, Yu-Li Shen, Lu Liu, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li

Publikováno v: CrystEngComm. 24:2777-2790

The cocrystal of 5-fluorocytosine (FCY) with vanillic acid (VAA) was assembled via a cocrystallization technique, giving a novel understanding for conquering the dose-limited hepatotoxicity caused by the rapid and almost complete absorption of FCY.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8a61a4caa859c3cfff1d09b2818d426
https://doi.org/10.1039/d2ce00114d

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Cocrystallization of Amantadine Hydrochloride with Resveratrol: The First Drug–Nutraceutical Cocrystal Displaying Synergistic Antiviral Activity

Autor: Yue-Ming Yu, Yuan-Yuan Niu, Cui-Wei Yan, Yan-Tuan Li, Fan-Zhi Bu, Zhi-Yong Wu, Ming-Yu Zhao, Ling-Yang Wang

Publikováno v: Crystal Growth & Design. 21:2763-2776

In order to highlight the advantages of the nutraceutical resveratrol (RVA) in perfecting the in vitro/in vivo properties of amantadine hydrochloride (ATHC), to realize advantageous complementariti...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2a65f0154fc1affa3824304ae5e2810
https://doi.org/10.1021/acs.cgd.0c01673

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A Sulfathiazole–Amantadine Hydrochloride Cocrystal: The First Codrug Simultaneously Comprising Antiviral and Antibacterial Components

Autor: Yan-Tuan Li, Fan-Zhi Bu, Zhi-Yong Wu, Ling-Yang Wang, Cui-Wei Yan

Publikováno v: Crystal Growth & Design. 20:3236-3246

A novel cocrystallization form of amantadine hydrochloride (AMNH) with sulfathiazole (SUZ), as the first example of dual-drug cocrystal simultaneously containing antiviral drug and antibacterial ag...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::597c96198214be2c7b1663f5a6643cca
https://doi.org/10.1021/acs.cgd.0c00075

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The supramolecular self-assembly of 5-fluorouracil and caffeic acid through cocrystallization strategy opens up a new way for the development of synergistic antitumor pharmaceutical cocrystal

Autor: Cheng Wang, Yan-Tuan Li, Yue-Ming Yu, Lin-Lin Wang, Fan-Zhi Bu, Zhi-Yong Wu, Ling-Yang Wang

Publikováno v: CrystEngComm. 22:7992-8006

In order to give full play to the superiority of cocrystallization techniques to overcome biopharmaceutical limitations in vitro and ameliorate pharmacokinetic properties in vivo together with heightening the antitumor abilities of the anticancer dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8f5fec345b6162e018cfeb4ccba3332
https://doi.org/10.1039/d0ce01297a

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