Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Fan-Lu Kung"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 12, Pp 1960-1971 (2023)
Abstract The anticonvulsant valproic acid (VPA) despite complex pharmacokinetics has been in clinical use for nearly 6 decades. Previous reports indicated neonates, infants, and toddlers/preschoolers had higher risk of valproate hepatotoxicity than a
Externí odkaz:
https://doaj.org/article/7d2a97493e2f42c1852e6b1e24f3f99a
Autor:
Hao-Cheng Weng, Chieh-Ju Sung, Jui-Ling Hsu, Wohn-Jenn Leu, Jih-Hwa Guh, Fan-Lu Kung, Lih-Ching Hsu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Breast cancer is the most prevalent cancer and the second leading cause of cancer death in women. Cisplatin is a commonly used chemotherapeutic drug for breast cancer treatment. Owing to serious side effects, the combination of cisplatin with other d
Externí odkaz:
https://doaj.org/article/87867dc881c5485886ec66bb7c2bddb4
Autor:
Ya-Fen Hsu, Fan-Lu Kung, Tzu-En Huang, Yi-Ning Deng, Jih-Hwa Guh, Paolo Marchetti, Elena Marchesi, Daniela Perrone, Maria Luisa Navacchia, Lih-Ching Hsu
Publikováno v:
Molecules, Vol 28, Iss 5, p 2358 (2023)
Hepatocellular carcinoma is the third most common cause of cancer-related death according to the International Agency for Research on Cancer. Dihydroartemisinin (DHA), an antimalarial drug, has been reported to exhibit anticancer activity but with a
Externí odkaz:
https://doaj.org/article/ff24007f53004f1a8586ea1f00420e9a
Publikováno v:
Molecules, Vol 27, Iss 22, p 8106 (2022)
Tumor cells rely on aerobic glycolysis to support growth and survival, thus require more glucose supply. Glucose transporters GLUTs, primarily GLUT1, are overexpressed in various cancers. Targeting GLUTs has been regarded as a promising anticancer st
Externí odkaz:
https://doaj.org/article/02764636511146bc83fe0dca96bfa076
Autor:
Fan-Lu Kung, Jung-Lung Tsai, Chien-Hsing Lee, Kuo-Long Lou, Chih-Yung Tang, Horng-Huei Liou, Kuan-Ling Lu, Yi-Hung Chen, Wun-Jheng Wang, Ming-Cheng Tsai
Publikováno v:
Journal of the Formosan Medical Association, Vol 107, Iss 8, Pp 600-608 (2008)
Background/Purpose: Inward rectifying potassium channel 6.2 (Kir6.2 Δ C26 channel) is closely related to ATP-sensitive potassium channels. Whether sodium azide, barium ion, d-amphetamine or procaine acts directly on the Kir6.2 Δ C26 channel remains
Externí odkaz:
https://doaj.org/article/f4bc47890e5a48a9bb418c136a1ff423
Autor:
Nai-You Zhang, Ting-Hsuan Wang, Ching-Hsuan Chou, Kuo-Chen Wu, Chia-Ron Yang, Fan-Lu Kung, Chun-Jung Lin
Publikováno v:
European Journal of Pharmacology. 933:175256
Many studies have indicated that the risk of cognitive impairment is higher in patients with rheumatoid arthritis (RA). Additionally, patients with RA may have a lower incidence of cognitive impairment with long-term use of ibuprofen. This study was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeae8a8b97bebf3edf331a53f7cd8d72
https://doi.org/10.1016/j.ejphar.2022.175256
https://doi.org/10.1016/j.ejphar.2022.175256
Autor:
Ling-Ling Hsieh, Fan-Lu Kung, Shyh-Jye Chen, Yunn-Fang Ho, Hua Chou, Fe-Lin Lin Wu, Kun-Lin Hsieh
Publikováno v:
American Journal of Roentgenology. 205:703-708
For unknown reasons, there is discordance among previous reports with regard to the association of contrast medium (CM) with nephropathy and the incidence of nephropathy after contrast-enhanced CT. This study aimed to determine the frequency of and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0310af123adde8499aca5a8dbf0273cb
https://doi.org/10.2214/ajr.15.14329
https://doi.org/10.2214/ajr.15.14329
Autor:
Fan-Lun Liu, Wohn-Jenn Leu, Ih-Sheng Chen, Chia-Chun Yu, Wei-Ling Chang, Fan-Lu Kung, Jih-Hwa Guh, Hsun-Shuo Chang, Lih-Ching Hsu, Jui-Ling Hsu
Publikováno v:
Oncotarget
Epi-reevesioside F, a new cardiac glycoside isolated from the root of Reevesia formosana, displayed potent activity against glioblastoma cells. Epi-reevesioside F was more potent than ouabain with IC50 values of 27.3±1.7 vs. 48.7±1.8 nM (P < 0.001)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff024e6a833fd094eb535e72336e3592
https://doi.org/10.18632/oncotarget.4429
https://doi.org/10.18632/oncotarget.4429
Autor:
Qing-qing Ye, Fan-Lu Kung, Ravindra Ramesh Deore, Chien Shu Chen, Ting-Rong Chern, Jung-Hsin Lin, Chen-Wei Huang, Ji-Wang Chern, Chao-Wu Yu, Rahul Subhash Talekar, Pei-Teh Chang, Grace Shiahuy Chen, Shin-Yu Lai, Min-Yan Yang
Publikováno v:
Neuropharmacology. 92:146-157
Alzheimer's disease is a neurodegenerative disorder characterized by deposition of β-amyloid (Aβ) fibrils accompanied with progressive neurite loss. None of the clinically approved anti-Alzheimer's agents target both pathological processes. We hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a6d786586a55e0e4bd4a05040593a7
https://doi.org/10.1016/j.neuropharm.2015.01.004
https://doi.org/10.1016/j.neuropharm.2015.01.004
Autor:
Po-Cheng Chiang, Jih-Hwa Guh, Yi-Cheng Chen, Chia-Chun Yu, Yunn-Fang Ho, Fan-Lu Kung, Pin-Hsuan Lu
Publikováno v:
Journal of Urology. 186:2434-2441
Emerging evidence shows that the translocation of apoptosis related factors on cellular organelles, such as mitochondria, endoplasmic reticulum, Golgi apparatus and nucleus, has a crucial role in the apoptotic process. We characterized the effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3700c5d0b2dc83af31d8b3375891b072
https://doi.org/10.1016/j.juro.2011.07.088
https://doi.org/10.1016/j.juro.2011.07.088